Preliminary Study of Brain Glucose Metabolism Changes in Patients with Lung Cancer of Different Histological Types

Abstract

Background:Cerebral glucose metabolism changes are always observed in patients suffering from malignant tumors. This preliminary study aimed to investigate the brain glucose metabolism changes in patients with lung cancer of different histological types.Methods:One hundred and twenty patients with primary untreated lung cancer, who visited People's Hospital of Zhengzhou University from February 2012 to July 2013, were divided into three groups based on histological types confirmed by biopsy or surgical pathology, which included adenocarcinoma (52 cases), squamous cell carcinoma (43 cases), and small-cell carcinoma (25 cases). The whole body 18F-fluorodeoxyglucose (18F-FDG) positron emission tomography (PET)/computed tomography (CT) of these cases was retrospectively studied. The brain PET data of three groups were analyzed individually using statistical parametric maps (SPM) software, with 50 age-matched and gender-matched healthy controls for comparison.Results:The brain resting glucose metabolism in all three lung cancer groups showed regional cerebral metabolic reduction. The hypo-metabolic cerebral regions were mainly distributed at the left superior and middle frontal, bilateral superior and middle temporal and inferior and middle temporal gyrus. Besides, the hypo-metabolic regions were also found in the right inferior parietal lobule and hippocampus in the small-cell carcinoma group. The area of the total hypo-metabolic cerebral regions in the small-cell carcinoma group (total voxel value 3255) was larger than those in the adenocarcinoma group (total voxel value 1217) and squamous cell carcinoma group (total voxel value 1292).Conclusions:The brain resting glucose metabolism in patients with lung cancer shows regional cerebral metabolic reduction and the brain hypo-metabolic changes are related to the histological types of lung cancer.

Changes of Brain Glucose Metabolism in the Pretreatment Patients with Non-Small Cell Lung Cancer: A Retrospective PET/CT Study

“…In this study, no significant differences were found in brain glucose uptake among clinical stages or between adenocarcinoma and squamous carcinoma patients. These results were partly in line with the study of Li and colleagues [ 31 ]. However, the effect of clinical stages or pathological types on brain glucose uptake might be related to the whole-body tumor burden.…”

Regional Brain Glucose Metabolism and Its Prognostic Value in Pretreatment Extranodal Natural Killer/T-Cell Lymphoma Patients

“…2,5,18,[23][24][25] Decreased cerebral blood flow, decreased metabolism, 1,2 and reduction of gray matter volume 26,27 in the PFC, OFC, and anterior cingulate cortex were also observed in depressive patients. Notably, these changes were proportional to depression severity 26 and could be partly recovered with attenuation of psychiatric symptoms 1,17,28 due to an effective therapeutic response. 2,29…”

“…It was reported associated with depression and chemobrain, 30 and such cerebral metabolism could see in Alzheimer’s disease too. 1 , 17 …”

“…It was reported associated with depression and chemobrain, 30 and such cerebral metabolism could see in Alzheimer's disease too. 1,17 Univariate analysis for PFS and OS revealed that MTV, TLG, SUVmaxLBGT/SUVmaxRC, SUVmaxRBGT/ SUVmaxLC, and multiple clinical factors were significantly associated with prognosis. In the subsequent multivariate analysis, only ECOG and PINKE scores were independent prognostic factors.…”

“…Abnormal brain glucose metabolism has parenthetically been observed and increasingly reported in patients with benign and malignant diseases even when the brain is spared. [1][2][3][4] Other studies have reported that there is a statistically significant negative correlation between the standard uptake value (SUV) in the brain and total lesion glycolysis (TLG) in patients with malignant diseases. Such decreased brain uptake has been attributed to competition between the brain and hypermetabolic tumor tissues.…”