Preliminary Study of Alterations in Human Red Blood Cells by Irradiation With High Energy Photons

Riquelme, Bibiana Doris; Estrada, Enrique; Castellini, Horacio; Acosta, Andrea; Chinelatto, Alejandro; Tac, Ivan; Borraz, Javier; Tullio, Liliana Di; Galassi, M E

doi:10.5151/biofisica2019-30

Cited by 1 publication

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“…Se ha visto, además, que la irradiación promueve la generación de especies reactivas del oxígeno y la peroxidación de lípidos de la membrana de los glóbulos rojos [3], incrementa la ©2024 Anales AFA permeabilidad de la membrana eritrocitaria al potasio, sodio y hemoglobina, y disminuye su deformabilidad [4][5][6][7][8]. Todos estos efectos sobre los glóbulos rojos reducen la viabilidad transfusional de las unidades irradiadas almacenadas disminuyendo su viabilidad de 42 a 28 días [9].…”

Section: Introductionunclassified

Preliminary Study of the Gamma-Radiation Effect on the Plasma Ions Concentration in Transfusion Units

Alet,

Porini,

Detarsio

et al. 2024

AnAFA

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Red blood cell concentrates are the most widely used component in blood transfusions. Gamma irradiation of the transfusion unit is indicated when a patient is at risk of developing transfusion-associated graft-versus-host disease. However, this irradiation exacerbates storage damage by increasing potassium and decreasing sodium plasmatic levels. These effects on red blood cells reduce the viability time of stored irradiated units. In this work, we study the different radiation dose effects on the concentration of plasmatic ions in the gamma-irradiated bags, which are attributed to possible membrane alterations of red blood cells and leukocytes. The result analysis shows that radiation, at the doses studied, does not affect glucose consumption. However, the permeability of the erythrocyte membrane increases with the radiation dose, indicating that these types of alterations could be dose-dependent. These results could help to design a new preservation medium to reduce radiation-induced membrane damage.

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