Preliminary studies on the clinical toxicity of 5-amino-7-hydroxy-l-v-triazolo[d]-pyrimidine (guanazolo)

Armistead, G. C.; Burchenal, Joseph H.; Karnofsky, David A.; Southam, Chester M.

doi:10.1002/1097-0142(194911)2:6<1087::aid-cncr2820020614>3.0.co;2-z

Cited by 19 publications

(2 citation statements)

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“…2,6-Diaminopurine therapy often leads to severe nausea, vomiting, and diarrhea3 but does not cause mouth ulcers, and 6-mercaptopurine rarely causes mouth ul-ceratiom6 Skin rashes and nausea and vomiting are produced by 8-azaguanine, and this compound has not caused hematopoietic depression. 1 A useful role for azaserine in the treatment of human neoplastic disease has not yet been established. In the series of forty-one patients described here, twenty adults with acute leukemia, carcinoma, sarcoma, and miscellaneous lymphomas showed no clinical improvement following twenty-eight adequate trials.…”

Section: Discussionmentioning

confidence: 99%

Clinical trials of O-diazoacetyl-L-serine (azaserine) in neoplastic disease

Ellison¹,

Karnofsky²,

Sternberg³

et al. 1954

Cancer

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Section: Discussionmentioning

confidence: 99%

Clinical trials of O-diazoacetyl-L-serine (azaserine) in neoplastic disease

Ellison¹,

Karnofsky²,

Sternberg³

et al. 1954

Cancer

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“…survey Reumatismo, 2012; 64 (1): [44][45][46][47][48][49][50][51][52][53][54] A short history of anti-rheumatic therapy VIII. The immunosuppressants G. Pasero 1 , P. Marson 2 1 Università di Pisa; 2 Unità di Aferesi Terapeutica, U.O.C.…”

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Short story of antirheumatic therapy.VIII. The immunodepressants

Pasero¹,

Marson²

2012

Reumatismo

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The use of immunosuppressive drugs in rheumatology is fairly recent, starting just after the Second World War with the introduction of the first alkylating agents in oncohematology. When it became clear that some rheumatic diseases, particularly rheumatoid arthritis and systemic lupus erythematosus, showed an immune-mediated pathogenesis, including proliferation of immunocompetent cells, an application was soon found for immunosuppressive drugs in their treatment. This review outlines the historical milestones that led to the current use of drugs belonging to the major groups of immunosuppressants, i.e. alkylating agents (cyclophosphamide), folic acid (methotrexate) and purine (azathioprine) antagonists. We will also talk about the history of cyclosporin A, the first "selective" immunosuppressive agent, and that of some immunoactive drugs used more recently in rheumatology, such as mycophenolate mofetil, dapson and thalidomide, is briefly described.

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