Preliminary Studies on Solid Lipid Microparticles of Loratadine for the Treatment of Allergic Reactions via the Nasal Route

Abstract

Purpose: To formulate solid lipid microparticles (SLM) of loratadine (LRT) for the treatment of allergic reactions via the nasal route. Methods: Microparticles were prepared by emulsion congealing technique. The drug content of microparticles was analysed. Drug/excipient compatibility and crystallinity characteristics of microparticles were investigated by Fourier Transform Infrared Spectroscopy (FT-IR) and differential scanning calorimetry (DSC). Particle size distribution was determined by laser diffraction (LD). Drug release from microparticles was compared to that from conventional vehicles (O/W emulsion

Solid Lipid Nanoparticles and Nanostructured Lipid Carriers of Loratadine for Topical Application: Physicochemical Stability and Drug Penetration through Rat Skin

“…Addition of liquid lipid to the lipophilic phase resulted in a slight increase in drug payload as reported earlier [7,8]. This was attributed to the higher solubility of LRT in liquid lipid compared to the solid lipid.…”

“…Determination of interaction between LRT and the other ingredients of SLN and NLC was investigated by FTIR after 6 months [8]. Nanoparticle dispersion was diluted with water and centrifuged at 13 000 rpm for 40 min.…”

“…Release profiles were evaluated using different models in order to determine one that best describes release mechanism of drug: zero order, which describes the release rate independent of drug concentration; first order, which describes the release rate dependent of concentration gradient; Higuchi, which is based on the Fick's law of diffusion; KorsemeyerPeppas which indicates the Fickian diffusion and non-Fickian diffusion, where n is the release exponent, indicative of mechanism of drug release (Eqs 4 -7) [8]. (7) where Q t and Q 0 = amounts of drug released at time, t, and in the release medium at t = 0, respectively, k 0 , k 1 and k H = release constants of the zero order, the first order and Higuchi square-root models, respectively, Q t /Q ∞ = fractional release of drug, k and n = kinetic constant and diffusional release exponent indicative of the release mechanism.…”

Influence of Vehicles and Penetration Enhancers on Anti-Inflammatory Effect of 18-Β Glycyrrhetinic Acid: Kinetic Modelling of Drug Release, in Vivo and Ex Vivo Experiments

“…The solubility of 18-β GA was determined in the receptor phase according to the method reported in USP XIX [14,16]. 10 mL of a pH 7.4 PBS:EtOH:PG (2:1:1, v/v/v) mixture as the receptor phase were placed in four 25 mL flasks for this purpose.…”

Loratadine self-microemulsifying drug delivery systems (SMEDDS) in combination with sulforaphane for the synergistic chemoprevention of pancreatic cancer

“…Some lipid-based systems have been reported in literature for LOR. These include LOR lipid-based solid formulation prepared by adsorption and milling technique with droplet size of 1.2 μm; solid lipid microparticles of LOR prepared by emulsion congealing technique, and lipid-based formulations comprising natural or digested lipids wherein LOR was used as a model drug [18–21]. Among various lipid-based systems, we rationalized use of oil/water (O/W) self-microemulsifying drug delivery systems (SMEDDS) for effective LOR delivery.…”