Preliminary studies for ciclopirox olamine determination by thermal lens spectrophotometry

Soto, César; Saavedra, R.; Toral, M. Inés; Nacaratte, Fallon; Poza, Cristian

doi:10.1016/j.microc.2016.06.004

Cited by 7 publications

(1 citation statement)

References 21 publications

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“…The development of a basic, precise, reliable, and repetitive Visible Spectrophoto-metric method for the quantification of Eltrombopag Olamine in bulk and in tablet dosage form is described in the current work. According to ICH Guidelines, the developed approach was validated [13][14][15][16][17][18][19][20][21][22][23][24][25][26][27].…”

Section: Introductionmentioning

confidence: 99%

Development and Validation of Visible Spectrophotometric Method for Estimation of Eltrombopag Olamine in Bulk and Tablet Dosage Form

Sreelatha,

RG,

Harshana

et al. 2023

JASR

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A simple and sensitive visible spectrophotometric method has been developed for the quantitative estimation of Eltrombopag Olamine in its bulk and tablet dosage form. It is an orally active ethanolamine salt of Eltrombopag, a smallmolecule, nonpeptide thrombopoietin receptor agonist with megakaryopoiesis-stimulating activity. The maximum absorbance of drug was found at 425nm. Eltrombopag Olamine was found to be dissolved in Methanol so it was used as solvent for the conduction of work. Linearity range for the method was finalized as 3-18 μg/ml with R2 value of 0.9995. % RSD less than 2 which is well within indicates the method is precise and robust. The % recovery rate was found to be 100-101% indicating the method’s accuracy. The method was validated as per ICH guidelines provided and the results were found to be satisfactory. LOD & LOQ values were obtained as 0.150 & 0.456 respectively. Stability studies shows that the drug is unstable in various stress conditions like acid, base, water and oxidation.

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