Preliminary results on the pathogenic effects of intratracheal exposure to one-dimensional nanocarbons

Grubek-Jaworska, H; Nejman, Patrycja; Czuminska, K.; Przybyłowski, Tadeusz; Huczko, A.; Lange, H.; Bystrzejewski, M.; Baranowski, Piotr; Chazan, Ryszarda

doi:10.1016/j.carbon.2005.12.011

Cited by 61 publications

(19 citation statements)

References 18 publications

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“…The followup study with analysis 90 days postexposure of six different types of MWCNTs administered in individual doses (12.5 mg) to guinea pigs found small differences between the types of MWCNTs (Grubek-Jaworska et al 2006; Huczko et al 2005). However, for all types of MWCNTs there were multifocal granulomas observed around the materials, inflammatory reactions of terminal and respiratory bronchioles, and in some animals, mild fibrosis in alveolar septa.…”

Section: Human Healthmentioning

confidence: 97%

Reviewing the Environmental and Human Health Knowledge Base of Carbon Nanotubes

Helland

Wick²,

Koehler

et al. 2007

Environ Health Perspect

385

104

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Carbon nanotubes (CNTs) are considered one of the most promising materials in nanotechnology, with attractive properties for many technologic applications. The different synthesis, purification, and postprocessing methods produce CNTs with different physical characteristics, which can be applied in different fields ranging from composite materials, medical applications, and electronics to energy storage. The widespread projected use of CNTs makes it important to understand their potential harmful effects. In this environmental health review we observed a remarkable range of results of some of the toxicology studies. The comparability should be improved by further standardization and introduction of reference materials. However, at present the findings of this review suggest several key points: a) there are different types of CNTs, and therefore they cannot be considered a uniform group of substances; and b) in environmental compartments, CNTs can be bioavailable to organisms. The properties of CNTs suggest a possible accumulation along the food chain and high persistence. In organisms the absorption, distribution, metabolism, excretion, and toxicity of CNTs depend on the inherent physical and chemical characteristics such as CNT functionalization, coating, length, and agglomeration state that are influenced by the external environmental conditions during CNT production, use, and disposal stages. Characterized exposure scenarios could therefore be useful when conducting toxicologic studies. However, CNTs produce a toxic response upon reaching the lungs in sufficient quantity; this reaction is produced in a time-and dose-dependent manner. The identification of possible risks to human health and environment is a prerequisite for a successful introduction of CNTs in future applications.

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Section: Human Healthmentioning

confidence: 97%

Reviewing the Environmental and Human Health Knowledge Base of Carbon Nanotubes

Helland

Wick²,

Koehler

et al. 2007

Environ Health Perspect

385

104

View full text Add to dashboard Cite

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“…The toxicity of CNTs includes macro-level effects on organisms, such as granuloma formation in alveoli in lungs of Cavia porcellus (Grubek-Jaworska et al 2006). The authors conducted inhalation studies and reported that CNT aggregates often become too large to pass directly through the alveolar walls, and instead build up and block alveolar space.…”

Section: Toxicitymentioning

confidence: 99%

Effects of suspended multi-walled carbon nanotubes on daphnid growth and reproduction

Alloy

2011

Ecotoxicology and Environmental Safety

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Multi-walled carbon nanotube aggregates can be suspended in the aqueous phase by natural organic matter. These aggregates are ingested by filter feeding zooplankton. Ingested aggregates result in decreased growth and decreased reproduction. These effects may be caused by reduction in energy input from normal feeding behavior.pH alters natural organic matter structure through changes in electrostatic repulsion. Altered natural organic matter structure changes multi-walled carbon nanotube aggregate size. This size variation with variation in pH is significant, but not large enough a change in size to alter toxicity, as the aggregate size range remains well within the particle size selection of the organisms.

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“…The studies are mostly focused on inhalation toxicology [2][3][4] or on effects of skin exposure [5,6]. There are also studies on implanted carbon nanotubes [7] as well as in vitro studies concerning the influence of SWCNT on different cell cultures (endothelial cells [8], macrophages [9] or osteoblasts [10]).…”

Section: Introductionmentioning

confidence: 99%

The study of the interaction of human mesenchymal stem cells and monocytes/macrophages with single‐walled carbon nanotube films

Kalbáčová

Kalbáč

Dunsch

et al. 2006

Physica Status Solidi (b)

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The influence of single-walled carbon nanotube (SWCNT) films on two different human cell types was investigated: primary mesenchymal stem cells (MSC) and the monocytes/macrophages cell line THP-1, the focus being on the metabolic activity of these cells. The SWCNT were free of impurity as was confirmed by Raman and VIS-NIR spectroscopy. No surfactant was used to minimize the effect of other agents on the behavior of the cells. The results obtained on SWCNT films were compared to those measured on carbon fibers (CF). The metabolic activity of the investigated cell types cultured on SWCNT film was only slightly reduced (about 20%), while carbon fibers led to a much stronger decrease (about 40%). The reaction of the cells depended on the cell number, with more cells showing less metabolic inhibition.

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Preliminary results on the pathogenic effects of intratracheal exposure to one-dimensional nanocarbons

Cited by 61 publications

References 18 publications

Reviewing the Environmental and Human Health Knowledge Base of Carbon Nanotubes

Reviewing the Environmental and Human Health Knowledge Base of Carbon Nanotubes

Effects of suspended multi-walled carbon nanotubes on daphnid growth and reproduction

The study of the interaction of human mesenchymal stem cells and monocytes/macrophages with single‐walled carbon nanotube films

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