Preliminary results on CSF biomarkers for hypothalamic dysfunction in Kleine–Levin syndrome

Lopez, Régis; Barateau, Lucie; Chenini, Sofiène; Dauvilliers, Yves

doi:10.1016/j.sleep.2014.07.022

Cited by 30 publications

(17 citation statements)

References 10 publications

(18 reference statements)

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“…The sleepiness during episodes is likely linked with decreased hypocretin levels, as has been demonstrated several times [11,12]. Several different hypotheses have been suggested including the existence of genetic or acquired brain abnormalities or neurometabolic dysfunction [1].…”

Section: Introductionmentioning

confidence: 94%

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Serum cytokine levels in Kleine–Levin syndrome

Kornum

Rico

et al. 2015

Sleep Medicine

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Section: Introductionmentioning

confidence: 94%

“…Time span between two samples within the same patient ranged from two weeks to two years. Age of onset was on average 13.9 years [7][8][9][10][11][12][13][14][15][16][17][18][19]. Average episode duration was 12.7 [6][7][8][9][10][11][12][13][14][15][16][17][18][19][20][21][22][23][24] days.…”

Section: Patient Cohortsmentioning

confidence: 99%

Serum cytokine levels in Kleine–Levin syndrome

Kornum

Rico

et al. 2015

Sleep Medicine

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“…A few studies have examined the comorbidity between the diagnoses of ADHD and narcolepsy [50][51][52]. In the study by Ohayon of a population of 320 narcoleptic subjects compared to 1464 controls, the rate of ADHD in childhood was 5.4 versus 2.5 %, respectively.…”

Section: Adhd and Central Disorders Of Hypersomnolence (Aka Hypersomnmentioning

confidence: 99%

Excessive Daytime Sleepiness in Patients With ADHD—Diagnostic and Management Strategies

Bioulac

Micoulaud-Franchi

Philip

2015

Curr Psychiatry Rep

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The links between attention-deficit hyperactivity disorder (ADHD) and sleep disorders remain unclear. Specific sleep disorders are a frequent comorbid condition associated with ADHD according to a categorical approach. However, sleep disorders can also induce ADHD-like symptoms according to a dimensional approach and are thought to be the consequence of excessive daytime sleepiness. It may thus be difficult for clinicians to differentiate the diagnosis of ADHD comorbid with a sleep disorder from sleep disorders with ADHD-like symptoms. This distinction could be important for the appropriate management of patients with dual complaints of trouble maintaining attention and daytime sleepiness. This paper summarizes the main sleep disorders associated with ADHD: sleep-related breathing disorders, sleep-related movement disorders, circadian rhythm sleep-wake disorders, and central disorders of hypersomnolence (aka hypersomnias). The history of presenting symptoms should be taken into account since ADHD is a neurodevelopmental disorder whereas ADHD symptoms comorbid with sleep disorder are not. Finally, we propose a model to clarify the links between ADHD, ADHD symptoms, and excessive daytime sleepiness induced by sleep disorders. Clinicians should therefore routinely assess, monitor, and manage the sleep problems of patients with ADHD who have both comorbidities and should search for the presence of ADHD symptoms in subjects with sleep disorders.

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“…We read with great interest the report by Lopez and colleagues, "Preliminary results on CSF biomarkers for hypothalamic dysfunction in Kleine-Levin syndrome (KLS)," which emphasized recurrent hypothalamic alteration as the pathophysiology of KLS [1]. We commend their serial case reports about cerebrospinal fluid (CSF) biomarker analysis, however, the underlying pathophysiology is still unclear [1,2].…”

mentioning

confidence: 99%

“…We commend their serial case reports about cerebrospinal fluid (CSF) biomarker analysis, however, the underlying pathophysiology is still unclear [1,2].…”

mentioning

confidence: 99%