Preliminary Results of the Use of a Stabilized Hypochlorous Acid Solution in the Management of Ralstonia Pickettii Biofilm on Silicone Breast Implants

Abstract

Noncytotoxic, 0.025% hypochlorous acid in normal saline, stabilized in amber glass, successfully eradicated Ralstonia pickettii in planktonic and mature biofilm on three types of silicone implants during initial five minute soak time and may be the preferred antimicrobial solution for pocket lavage. This preliminary study requires further investigation. Leaching and implant compatibility testing is currently in progress.

Hypochlorous acid water prevents postoperative intrauterine infection after microwave endometrial ablation

“…12 In vitro studies have reported that HClO rapidly kills gram-positive and gram-negative microorganisms, including methicillin-resistant Staphylococcus aureus and vancomycin-resistant Enterococcus 3 . Therefore, the uterine cavity is rapidly sterilized by douche using HClO, probably in a few seconds, similar to the oral cavity before dental treatment, 8 breast implant pockets, 9 or the immediate and delayed debridement irrigation. 10 In the experimentally infected rat, the administration of a 10 ppm HClO solution in drinking water was effective in inhibiting horizontal spread of Pseudomonas aeruginosa infection among cage mates.…”

“…In vitro studies have reported that HClO rapidly kills gram‐positive and gram‐negative microorganisms, including methicillin‐resistant Staphylococcus aureus and vancomycin‐resistant Enterococcus 3 . Therefore, the uterine cavity is rapidly sterilized by douche using HClO, probably in a few seconds, similar to the oral cavity before dental treatment, 8 breast implant pockets, 9 or the immediate and delayed debridement irrigation 10…”

“…[5][6][7] In recent years, it has been used for both plaque control in dentistry 8 and in medical fields. For example, HClO is used in breastenlargement surgery for sanitization of the implant pocket, 9 HClO irrigation with ultrasound debridement can reduce bacterial growth and colony counts in chronic open wounds. 10 More recently, intraabdominal lavage of hypochlorous acid has been reported as a new paradigm for the septic and open abdomen.…”

Antimicrobial Irrigation and Technique during Breast Augmentation: Survey of Current Practice

“…8,10 Notably, this is the first time that Hibiclens, a soap form of chlorhexidine, has been reported as pocket irrigation. Additionally, after multiple reports of efficacy in biofilm penetration, 26 PhaseOne (Integrated Healing Technologies, Nashville, Tenn.) was identified as a preferred pocket irrigation solution by some respondents.…”

“…In 2017, Fisher reintroduced the concept of time-dependent efficacy of irrigation solutions in breast augmentation. 26 Pharmacologically, the efficacy of some antibiotics, such as Ancef, is dependent on time rather than concentration, such as with Gentamycin. 27 In contrast to reconstructive and implant-salvage procedures where evacuative drain placement is routine, pocket irrigation dwell time may be less significant in augmentation mammaplasty when the solution is left in the pocket, as suggested by Adams, thereby achieving prolonged exposure times.…”