Primary percutaneous coronary intervention for acute myocardial infarction offers the highest effectiveness in achieving patency of the infarct-related artery. However, the presence of normal coronary flow in the infarct-related artery does not always translate into the restoration of myocardial perfusion through cardiac microcirculation. Several pharmacological agents, as well as mechanical devices (i.e., aspiration catheters, mechanical thrombectomy, distal protection devices) were introduced in recent years to reduce the risk of distal embolization during primary percutaneous coronary intervention and to improve myocardial reperfusion. Recently, a new device has been introduced in the market, aiming to protect microcirculation: the MGuard™ stent (InspireMD, Tel Aviv, Israel), a bare-metal stent covered by micronlevel mesh, which prevents distal embolization by blocking the prolapse of thrombi through the stent struts during deployment. This article discusses data concerning safety and efficacy of mesh-covered stent implantation in an ST-segment elevation myocardial infarction setting.KEYWORDS: embolization n mesh n myocardial infarction n primary angioplasty n stent n thrombus