Preliminary results of pinpoint plantar long-wavelength infrared light irradiation on blood glucose, insulin and stress hormones in patients with type 2 diabetes mellitus

Ryotokuji, Kenji; Ishimaru, Keisou; Kihara, Kazuhiko; Namiki, Yoshihisa; Hozumi, Nobumichi

doi:10.5978/islsm.13-or-18

Cited by 11 publications

(3 citation statements)

References 5 publications

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“…Ryotokuji et al indicated that four weeks of FIR radiation administered to the feet of type 2 DM patients significantly reduced cortisol levels and blood glucose levels. 47 Therefore, assuming that FIR therapy normalizes blood glucose levels by reducing serum levels of cortisol (adrenal glucocorticoid hormones) and thereby improves the ability to respond to insulin action in patients with type 2 DM is reasonable.…”

Section: Effects Of Fir On Dmmentioning

confidence: 99%

RETRACTED: Far-infrared therapy for cardiovascular, autoimmune, and other chronic health problems: A systematic review

Shui

Wang

Chiang

et al. 2015

Exp Biol Med (Maywood)

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Physical therapy (physiotherapy), a complementary and alternative medicine therapy, has been widely applied in diagnosing and treating various diseases and defects. Increasing evidence suggests that convenient and non-invasive far-infrared (FIR) rays, a vital type of physiotherapy, improve the health of patients with cardiovascular disease, diabetes mellitus, and chronic kidney disease. Nevertheless, the molecular mechanisms by which FIR functions remain elusive. Hence, the purpose of this study was to review and summarize the results of previous investigations and to elaborate on the molecular mechanisms of FIR therapy in various types of disease. In conclusion, FIR therapy may be closely related to the increased expression of endothelial nitric oxide synthase as well as nitric oxide production and may modulate the profiles of some circulating miRNAs; thus, it may be a beneficial complement to treatments for some chronic diseases that yields no adverse effects.

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Section: Effects Of Fir On Dmmentioning

confidence: 99%

RETRACTED: Far-infrared therapy for cardiovascular, autoimmune, and other chronic health problems: A systematic review

Shui

Wang

Chiang

et al. 2015

Exp Biol Med (Maywood)

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“…Our previous study showed that pinpoint plantar longwavelength infrared light irradiation (PP-LILI) stimuli normalizes blood flow and pressure, suppresses ACTH and cortisol levels and improves type II diabetes [1][2][3] . All these evidences suggested that PP-LILI stimuli affect systemic homeostasis and thus it was thought that the stimuli also affect immune system.…”

Section: Discussionmentioning

confidence: 99%

Effect of Stress-Free Therapy on immune system: Induction of Interleukin 10 expression in lymphocytes through activation of CD19(+) CD24(hi) CD38(hi) regulatory B Cells

et al. 2015

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Background and aims:Mild thermal treatment with "Pinpoint Plantar Long-wavelength Infrared Light Irradiation (PP-LILI)" named as Stress-Free Therapy ® increases peripheral-deep body temperature and blood flow, and improves multiple disorders including hyperpiesia, type II diabetes and cardiovascular patients. Immunomodulatory effects of PP-LILI were investigated. Materials and methods: Seven healthy individuals and 4 people with underlying medical condition (UMC) participated in this study. Participants were given PP-LILI stimuli twice a week over 3 weeks and followed with placebo stimuli over 3 weeks. This set of sessions was repeated 3 times. For analyses, fresh peripheral mononuclear cells from participants were stained with fluorescencedye conjugated monoclonal antibodies and changes in populational compositions and IL-10 expression levels were observed by flow cytometry. Results: Distinct expression of IL-10 in lymphocytes was induced by PP-LILI from the second session in the healthy individuals. This induction was terminated during the following placebo sessions. PP-LILI induced activation of CD19 + CD24 hi CD38 hi regulatory B cells in every session prior to induce the IL-10 in major lymphocytes. Activated regulatory B cells in the individuals with UMC decreased as same levels of healthy individuals after second PP-LILI session and re-activated with the stimuli. Significant population changes in neither regulatory T cells nor proinflammatory IL-17A expressing CD4 + T cells were observed. Conclusions: PP-LILI is a potent immunomodulatory inducer that activates regulatory B cells and consequent IL-10 expression in lymphocytes. Moreover, its stimulatory intervals down-regulate the higher activation of regulatory B cells and lymphocyte's IL-10 expression occurred by UMC to the healthy people's level.

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“…Previous studies revealed that far-infrared radiation therapy to the feet of type 2 DM patients significantly reduced cortisol and blood glucose levels. 15 Far-infrared radiation has generally been evaluated as an effective, safe, and nonpharmacologic alternative for pain relief. Farinfrared rays can induce both thermal and nonthermal effects at the molecular level to influence the health of a whole living organism.…”

Section: Introductionmentioning

confidence: 99%

Evaluating the Far-Infrared Radiation Bioeffects on Micro Vascular Dysfunction, Nervous System, and Plantar Pressure in Diabetes Mellitus

Cheng

Lung

Jan

et al. 2019

The International Journal of Lower Extremity Wounds

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The most frequent clinical complication is diabetes. Diabetes is characterized by elevated blood glucose levels resulting in sensory nerve damage or lesions. Diabetic foot wounds are often slow to heal and require medical attention and monitoring. This study evaluates the effect of far-infrared radiation on the microcirculation and plantar pressure in the diabetic foot. Ten diabetics and 4 nondiabetics were recruited in this study. The diabetic group was examined before and after the intervention in each month for 3 consecutive months. Four nondiabetic groups were also measured before and after the intervention for 2 weeks in each month. The surface temperature and blood flow in the diabetic foot was significantly improved (temperature: 32.1 ± 2.3°C vs 33.5 ± 2.2°C, P < .05; blood flow image: 118.3 ± 58.1 PU [perfusion unit] vs 50.4 ± 4.3 PU, P < .05). The sympathetic nerve activity index LF also increased from 40.8 ± 18.6% to 61.8 ± 13.5% ( P = .07) in the second month. Plantar pressure tended to increase in the third month. This might indicate that far-infrared radiation could affect the mechanical properties of the plantar foot soft tissue. These results indicated that the effects of far-infrared radiation would improve blood circulation and change the soft tissue properties in the diabetic foot.

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Preliminary results of pinpoint plantar long-wavelength infrared light irradiation on blood glucose, insulin and stress hormones in patients with type 2 diabetes mellitus

Cited by 11 publications

References 5 publications

RETRACTED: Far-infrared therapy for cardiovascular, autoimmune, and other chronic health problems: A systematic review

RETRACTED: Far-infrared therapy for cardiovascular, autoimmune, and other chronic health problems: A systematic review

Effect of Stress-Free Therapy on immune system: Induction of Interleukin 10 expression in lymphocytes through activation of CD19(+) CD24(hi) CD38(hi) regulatory B Cells

Evaluating the Far-Infrared Radiation Bioeffects on Micro Vascular Dysfunction, Nervous System, and Plantar Pressure in Diabetes Mellitus

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