Preliminary results of highly localized plantar irradiation with low incident levels of mid-infrared energy which contributes to the prevention of dementia associated with underlying diabetes mellitus

Ryotokuji, Kenji; Ishimaru, Keisou; Kihara, Kazuhiko; Nakajima, Takuma; Otani, Satoru; Namiki, Yoshihisa

doi:10.5978/islsm.15-or-03

Cited by 3 publications

(5 citation statements)

References 16 publications

Supporting

Mentioning

Contrasting

Order By: Relevance

“…It was previously shown in human subjects that the peripheral mild-heat stimulation decreases blood ACTH and cortisol, and increases the core body temperature and the cerebral blood flow [12]- [14]. The present study extended these results by using the laboratory animals for the first time.…”

Section: Discussionsupporting

confidence: 68%

“…The temperature of stimulation was set at 43˚C, and the duration of stimulation was 5 min/day, which was repeated 3 times a week for 2 weeks. This stimulation parameter is based on the previous human studies [12]- [14], slightly modified to accelerate data acquisition. Control mice received only isoflurance anesthesia.…”

Section: Mild-heat Stimulation Methodsmentioning

confidence: 99%

“…PCT [Patent Cooperration Theaty]/JP [Japan] 2012/073972). Thus, application of a mild-heat stimulation at a specific plantar part with the PP-LILI was shown to cause a decrease of blood ACTH, an increase of deep body temperature, and an increase of bran blood flow [12]- [14], which are expected to have anti-anxiety effects. This novel method draws attention as a possible therapeutic option to treat stress-related disorders.…”

Section: Introductionmentioning

confidence: 99%

See 2 more Smart Citations

The Impact of Chronic Social Stress on Emotional Behavior in Mice and the Therapeutic Effect of Peripheral Mild-Heat Stimulation

Hang¹,

Yamaguchi²,

Ryotokuji³

et al. 2015

Health

Self Cite

View full text Add to dashboard Cite

In today's stressful society, mental diseases such as adjustment disorder, affective disorders including anxiety and depression, and chronic fatigue syndrome could be attributed to social stress and are considered as serious social problems. It has been long known in the acupuncture and moxibustion therapies in Japan and China that stimulation at Zhongwan and Taichong points have effects on stress-related anxiety and depression. In the present study, we therefore tested the effect of peripheral mild-heat stimulation at Zhongwan and Taichong on anxiety and brain biochemistry using a mouse model of chronic social stress. Male ddY mice (4 weeks old) were stressed by isolated rearing for 6 weeks. They received mild-heat stimulation (43˚C for 5 min) at Zhongwan and Taichong under isoflurane anesthesia after 4 weeks of the social isolation 3 times a week for 2 weeks, using the "Stress Free Apparatus" (Ryoken Co., Ltd). Control mice received only isoflurane anesthesia. Group-reared mice also underwent the same stimulus/anesthesia sessions. Two days after the last peripheral heat stimulation, anxiety was determined by the light/dark box test as the time spent in the light compartment and the number of transfer between the light and dark compartments. Before and after the last stimulation, blood was collected from an artery at the back of H. Liu et al. 1295 the eye, and serum corticosterone, immunoglobulin E (IgE) which was an index of the inflammatory immune system, and interleukin 6 (IL-6) were measured using ELISA Kit. The frontal cortex was collected after the behavioral test, and the dopamine and serotonin contents were measured also by ELISA Kit. A significant decrease of the time spent in the light compartment was observed after the isolated rearing (p < 0.01). Mild-heat stimulation significantly increased the time spent in the light compartment, indicating an anti-anxiety effect. Serum corticosterone, IgE and IL-6 were increased after stress, and the amount of serotonin in the frontal cortex was found decreased. The increased corticosterone, IgE and IL-6 were cancelled by mild-heat stimulation. These results suggest that chronic social isolation has negative biological and emotional impacts in mice and that peripheral mild-heat stimulation alleviates at least part of these stress effects.

show abstract

Section: Discussionsupporting

confidence: 68%

Section: Mild-heat Stimulation Methodsmentioning

confidence: 99%

Section: Introductionmentioning

confidence: 99%

See 1 more Smart Citation

The Impact of Chronic Social Stress on Emotional Behavior in Mice and the Therapeutic Effect of Peripheral Mild-Heat Stimulation

Hang¹,

Yamaguchi²,

Ryotokuji³

et al. 2015

Health

Self Cite

View full text Add to dashboard Cite

show abstract

“…We previously reported that pinpoint plantar long-wavelength infrared light irradiation (stress-free therapy; SFT) suppresses the stress reaction mediated by cortisol and contributes to alleviation of insulin resistance and elevation of intracranial blood flow in patients with type 2 DM. 5 , 6 , 7 , 8 We have additionally demonstrated that SFT activates the immunoresponsive CD19 + CD24hi and CD38hi B-reg cell groups and induces the expression of IL-10 on lymphocytes. 9 …”

Section: Introductionmentioning

confidence: 67%

“…3 , 11 SFT has already demonstrated efficacy in alleviating DM and dementia and is expected to be useful for preventing Sdiabetes-related dementia by alleviating insulin resistance and increasing intracranial blood flow. 7 , 8 …”

Section: Discussionmentioning

confidence: 99%

Influences of Pinpoint Plantar Long-Wavelength Infrared Light Irradiation (Stress-Free Therapy) on Chorioretinal Hemodynamics, Atherosclerosis Factors, and Vascular Endothelial Growth Factor

Ishimaru

Nakajima

Namiki

et al. 2018

Integrative Medicine Research

Self Cite

View full text Add to dashboard Cite

BackgroundWe previously reported that pinpoint plantar long-wavelength infrared light irradiation (stress-free therapy; SFT) is useful for alleviating insulin resistance and improving intracranial blood flow in patients with type 2 diabetes mellitus. This study was undertaken to evaluate the influences of SFT on chorioretinal hemodynamics (retinal artery and vein blood flows) as well as atherosclerosis-related factors (TG, LDL-C) and VEGF in patients with dyslipidemia.MethodsFour patients with dyslipidemia received 15-minute irradiation with a stress-free apparatus (far-infrared wavelength, 30 mW). Using laser speckle flowgraphy, associations of chorioretinal blood flow with peripheral atherosclerosis-inducing factors/VEGF levels before and after irradiation were analyzed.ResultsChorioretinal blood flow increased, while TG/LDL-C levels decreased, after irradiation. VEGF tended to rise in cases with pre-irradiation baseline levels at the lower limit but tended to decrease in cases in which baseline levels had exceeded the normal range.ConclusionSFT was suggested to enhance chorioretinal circulation and to normalize VEGF, thereby possibly contributing to amelioration of atherosclerosis-inducing factors. Abnormalities in chorioretinal hemodynamics are known to be highly involved in the pathophysiology of diabetic retinopathy and age-related macular degeneration, and anti-VEGF antibody has been used for treating these conditions. The necessity of risk management, involving chorioretinal blood flow, has been pointed out when dealing with central retinal vein occlusion, diabetes mellitus, ischemic cerebral/cardiac disease, dementia and so on. SFT is therefore a potential complementary medical strategy which can be expected to contribute to normalization of chorioretinal blood flow and atherosclerosis-inducing factors/VEGF levels, and thereby to the prevention of lifestyle-related chronic diseases.

show abstract

Clinical Efficacy of Stress-Free Therapy in Two Patients with Glaucoma

Ishimaru

Nakajima

Kashiki

et al. 2022

Integrative Medicine Reports

View full text Add to dashboard Cite

Preliminary results of highly localized plantar irradiation with low incident levels of mid-infrared energy which contributes to the prevention of dementia associated with underlying diabetes mellitus

Cited by 3 publications

References 16 publications

The Impact of Chronic Social Stress on Emotional Behavior in Mice and the Therapeutic Effect of Peripheral Mild-Heat Stimulation

The Impact of Chronic Social Stress on Emotional Behavior in Mice and the Therapeutic Effect of Peripheral Mild-Heat Stimulation

Influences of Pinpoint Plantar Long-Wavelength Infrared Light Irradiation (Stress-Free Therapy) on Chorioretinal Hemodynamics, Atherosclerosis Factors, and Vascular Endothelial Growth Factor

Clinical Efficacy of Stress-Free Therapy in Two Patients with Glaucoma

Contact Info

Product

Resources

About