Preliminary results of a phase I/II study of HDR brachytherapy alone for T1/T2 breast cancer

Wazer, David E.; Berle, L.P.; Graham, Roger A.; Chung, Maureen A.; Rothschild, Janice G.; Graves, Theresa A.; Cady, Blake; Ulin, Kenneth; Ruthazer, Robin; DiPetrillo, Thomas A.

doi:10.1016/s0360-3016(02)02824-9

Cited by 185 publications

(89 citation statements)

References 21 publications

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“…Several phase I and II studies evaluating accelerated PBRT have reported promising early results, with few local tumor relapses, while maintaining excellent cosmetic outcomes and minimum toxicity (4)(5)(6)(7). Currently, PBRT for early breast cancer is being investigated in several phase III randomized studies (8)(9)(10)(11)(12).…”

Section: Introductionmentioning

confidence: 99%

Ipsilateral Breast Tumor Relapse: Local Recurrence Versus New Primary Tumor and the Effect of Whole-Breast Radiotherapy on the Rate of New Primaries

Gujral

Sumo

Owen³

et al. 2011

International Journal of Radiation Oncology*Biology*Physics

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Purpose: The justification for partial breast radiotherapy after breast conservation surgery assumes that ipsilateral breast tumor relapses (IBTR) outside the index quadrant are mostly new primary (NP) tumors that develop despite radiotherapy. We tested the hypothesis that whole-breast radiotherapy (WBRT) is ineffective in preventing NP by comparing development rates in irradiated and contralateral breasts after tumor excision and WBRT. Methods and Materials: We retrospectively reviewed 1,410 women with breast cancer who were entered into a prospective randomized trial of radiotherapy fractionation and monitored annually for ipsilateral breast tumor relapses (IBTR) and contralateral breast cancer (CLBC). Cases of IBTR were classified into local recurrence (LR) or NP tumors based on location and histology and were subdivided as definite or likely depending on clinical data. Rates of ipsilateral NP and CLBC were compared over a 15-year period of follow-up. Results: At a median follow-up of 10.1 years, there were 150 documented cases of IBTR: 118 (79%) cases were definite or likely LR; 27 (18%) cases were definite or likely NP; and 5 (3%) cases could not be classified. There were 71 cases of CLBC. The crude proportion of definite-plus-likely NP was 1.9% (27/1,410) patients compared with 5% (71/1,410) CLBC patients. Cumulative incidence rates at 5, 10, and 15 years were 0.8%, 2.0%, and 3.5%, respectively, for definite-plus-likely NP and 2.4%, 5.8%, and 7.9%, respectively for CLBC, suggesting a difference in the rates of NP and CLBC. Conclusions: This analysis suggests that WBRT reduces the rate of ipsilateral NP tumors. The late presentation of NP has implications for the reporting of trials that are testing partial breast radiotherapy. Ó 2011 Elsevier Inc.Breast cancer, Ipsilateral, Contralateral, Relapse, Radiotherapy.

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Section: Introductionmentioning

confidence: 99%

Ipsilateral Breast Tumor Relapse: Local Recurrence Versus New Primary Tumor and the Effect of Whole-Breast Radiotherapy on the Rate of New Primaries

Gujral

Sumo

Owen³

et al. 2011

International Journal of Radiation Oncology*Biology*Physics

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“…Overall, the technique may reduce exposure to radiation healthy tissue and body organs, such as the heart and lungs (Dickler et al 2007;Milele et al 2009). Additionally, APBI has demonstrated equivalent control rates to whole breast irradiation following BCS in several studies (King et al 2000;Vinci et al 2001;Wazer et al 2002).…”

Section: Intralesionalmentioning

confidence: 99%

Experimental Therapies in Breast Cancer

Rabatic

2014

Medical Radiology

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“…Interstitial implants have been in use for over 10 years and published reports describe excellent results; however, these are mainly single-institution Phase I/II studies [39][40][41][42][43][44][45][46]. The largest matched-pair analysis from the William Beaumont Hospital compared 199 interstitial catheter APBI patients treated between 1980 and 1997 with 199 WBRT patients randomly selected from 709 eligible control subjects [39].…”

Section: Brachytherapymentioning

confidence: 99%

Partial breast irradiation: a review of techniques and indications

Stewart

Khan²,

Devlin³

2010

BJR

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ABSTRACT. The addition of whole-breast external beam radiotherapy (EBRT) to breastconserving surgery results in a significant reduction in the risk of death due to breast cancer, but this may be offset by an increase in deaths from other causes and toxicity to surrounding organs. Because of this, and with a view to patterns of local recurrence, irradiation of the tumour bed has been explored in selected patients with early breast cancer using a variety of radiotherapeutic modalities. This review article explores the treatment options for partial breast irradiation and examines their role within the field of breast cancer treatment.

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Preliminary results of a phase I/II study of HDR brachytherapy alone for T1/T2 breast cancer

Cited by 185 publications

References 21 publications

Ipsilateral Breast Tumor Relapse: Local Recurrence Versus New Primary Tumor and the Effect of Whole-Breast Radiotherapy on the Rate of New Primaries

Ipsilateral Breast Tumor Relapse: Local Recurrence Versus New Primary Tumor and the Effect of Whole-Breast Radiotherapy on the Rate of New Primaries

Experimental Therapies in Breast Cancer

Partial breast irradiation: a review of techniques and indications

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