Preliminary results, methodological considerations and recruitment difficulties of a randomised clinical trial comparing two treatment regimens for patients with headache and neck pain

Hertogh, Willem De; Vaes, Peter; Devroey, Dirk; Louis, Paul; Carpay, Hans A.; Truijen, Steven; Duquet, William; Oostendorp, Rob A.B.

doi:10.1186/1471-2474-10-115

Cited by 33 publications

(56 citation statements)

References 29 publications

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“…[27][28][29][30][31][32][33][34][35][36][37][38][39][40] Fig. 17,19,[22][23][24][25] Methodological quality of the studies Methodological quality was considered acceptable in 12 (85%) of the studies 27,29,30,[32][33][34][35][36][37][38][39][40] and poor in the remaining 2. 17,19,[22][23][24][25] Methodological quality of the studies Methodological quality was considered acceptable in 12 (85%) of the studies 27,29,30,[32][33][34][35][36][37][38][39]…”

Section: Resultsmentioning

confidence: 99%

“…Eleven studies [27][28][29][30][31][32][33]35,37,38,40 analysed changes in headache frequency after the intervention. All groups receiving manual therapy showed a statistically significant decrease in headache frequency.…”

Section: Results Of the Interventionsmentioning

confidence: 99%

“…The most frequent inclusion criterion [27][28][29][30][31][32][33][34][35][36][38][39][40] among studies was diagnosis of TTH according to the classification of the International Headache Society. The most frequent inclusion criterion [27][28][29][30][31][32][33][34][35][36][38][39][40] among studies was diagnosis of TTH according to the classification of the International Headache Society.…”

Section: Characteristics Of the Study Populationmentioning

confidence: 99%

“…De Hertogh et al 33 analysed manual therapy consisting of joint mobilisations of the vertebral column (low-and/or high-velocity) and a programme of low-load endurance exercises (cranio-cervical flexion). De Hertogh et al 33 analysed manual therapy consisting of joint mobilisations of the vertebral column (low-and/or high-velocity) and a programme of low-load endurance exercises (cranio-cervical flexion).…”

Section: Studymentioning

confidence: 99%

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Efficacy of manual therapy in the treatment of tension-type headache. A systematic review from 2000 to 2013

López

Jiménez

Aizpurua

et al. 2016

Neurología (English Edition)

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Objectives: To study the efficacy of manual therapy in the treatment of tension-type headache (TTH) by assessing the quality of randomised control trials (RCTs) published from the year 2000 to April 2013.Methods: A search was performed in the following databases: MEDLINE, EBSCO, CINAHL, SCO-PUS, PEDRO and OVID. An analysis was made of RCT including patients with TTH receiving any manual therapy, and assessing outcome measures including the intensity, and frequency or duration of the headache. Two independent referees reviewed the methodological quality of RCTs using the Jadad scale. Data from the studies were extracted by two different reviewers.Results: A total of fourteen RCTs were selected. Twelve studies showed acceptable quality (Jadad scale ≥3), and the remaining 2 had low quality (Jadad = 2). The studies showed positive results, including reduction in headache intensity and/or frequency, reduction of medication consumption, and improvement in quality of life. Conclusions:The effectiveness of manual therapy for TTH cannot be completely assessed due to the heterogeneity in study design, outcome measures, and different treatments. Nevertheless, the results suggest patients with TTH receiving manual therapies showed better progress than those receiving conventional treatment or placebo. Further studies of high quality using ଝ Please cite this article as: Lozano López C, Mesa Jiménez J, de la Hoz Aizpurúa JL, Pareja Grande J, Fernández de las Peñas C. Eficacia de la terapia manual en el tratamiento de la cefalea tensional. Una revisión sistemática desde el año 2000 hasta el 2013. Neurología. 2016 http://dx.

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Section: Resultsmentioning

confidence: 99%

Section: Results Of the Interventionsmentioning

confidence: 99%

Section: Characteristics Of the Study Populationmentioning

confidence: 99%

Section: Studymentioning

confidence: 99%

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Efficacy of manual therapy in the treatment of tension-type headache. A systematic review from 2000 to 2013

López

Jiménez

Aizpurua

et al. 2016

Neurología (English Edition)

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“…This was due to the difficulty in finding CM participants who fitted the criteria, and this is common in research involving chronic headache patients 43,44…”

Section: Limitationsmentioning

confidence: 99%

A double-blind, randomized, placebo-controlled pilot trial to determine the efficacy and safety of ibudilast, a potential glial attenuator, in chronic migraine

Kwok¹,

Swift²,

Gazerani³

et al. 2016

JPR

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BackgroundChronic migraine (CM) is problematic, and there are few effective treatments. Recently, it has been hypothesized that glial activation may be a contributor to migraine; therefore, this study investigated whether the potential glial inhibitor, ibudilast, could attenuate CM.MethodsThe study was of double-blind, randomized, placebo-controlled, two-period crossover design. Participants were randomized to receive either ibudilast (40 mg twice daily) or placebo treatment for 8 weeks. Subsequently, the participants underwent a 4-week washout period followed by a second 8-week treatment block with the alternative treatment. CM participants completed a headache diary 4 weeks before randomization throughout both treatment periods and 4 weeks after treatment. Questionnaires assessing quality of life and cutaneous allodynia were collected on eight occasions throughout the study.ResultsA total of 33 participants were randomized, and 14 participants completed the study. Ibudilast was generally well tolerated with mild, transient adverse events, principally nausea. Eight weeks of ibudilast treatment did not reduce the frequency of moderate to severe headache or of secondary outcome measures such as headache index, intake of symptomatic medications, quality of life or change in cutaneous allodynia.ConclusionUsing the current regimen, ibudilast does not improve migraine with CM participants.

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The comparative effects of spinal manipulation, myofascial release and exercise in tension-type headache patients with neck pain: A randomized controlled trial

Corum¹,

Aydın²,

Ceylan³

et al. 2021

Complementary Therapies in Clinical Practice

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Preliminary results, methodological considerations and recruitment difficulties of a randomised clinical trial comparing two treatment regimens for patients with headache and neck pain

Cited by 33 publications

References 29 publications

Efficacy of manual therapy in the treatment of tension-type headache. A systematic review from 2000 to 2013

Efficacy of manual therapy in the treatment of tension-type headache. A systematic review from 2000 to 2013

A double-blind, randomized, placebo-controlled pilot trial to determine the efficacy and safety of ibudilast, a potential glial attenuator, in chronic migraine

The comparative effects of spinal manipulation, myofascial release and exercise in tension-type headache patients with neck pain: A randomized controlled trial

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