Preliminary Report of Microcephaly Potentially Associated with Zika Virus Infection During Pregnancy — Colombia, January–November 2016

Cuevas, Esther Liliana; Tong, Van T.; Rozo, Nathaly; Valencia, Diana; Pacheco, Óscar; Gilboa, Suzanne M.; Mercado, Marcela; Renquist, Christina M.; González, Maribel Castellano; Ailes, Elizabeth C.; Duarte, Carolina; Godoshian, Valerie; Sancken, Christina L; Turca, Angélica María Rico; Calles, Dinorah L; Ayala, Martha; Morgan, Paula; Perez, Erika Natalia Tolosa; Bonilla, Hernan Quijada; Gomez, Ruben Caceres; Estupiñán, Ana Carolina; Gunturiz, María Luz; Meaney‐Delman, Dana; Jamieson, Denise J.; Honein, Margaret A.; Martinez, Martha

doi:10.15585/mmwr.mm6549e1

Cited by 101 publications

(97 citation statements)

References 7 publications

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“…This is an alarming situation because of congenital defects associated with ZIKV infection. Such congenital defects cases have increased since 2016 [1–3]. The number of cases confirmed in laboratories is lower (9.7%) than reported in other countries [3, 4].…”

Section: Introductionmentioning

confidence: 99%

Case report: microcephaly associated with Zika virus infection, Colombia

et al. 2017

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BackgroundRecently there has been a large outbreak of Zika virus infections in Colombia, South America. The epidemic began in September 2015 and continued to April 2017, for the total number of Zika cases reported of 107,870. For those confirmed Zika cases, there were nearly 20,000 (18.5%) suspected to be pregnant women, resulting in 157 confirmed cases of microcephaly in newborns reported by their health government agency. There is a clear under-estimation of the total number of cases and in addition no prior publications have been published to demonstrate the clinical aspects of the Zika infection in Colombia. We characterized one Zika presentation to be able to compare and contrast with other cases of Zika infection already reported in the literature.Case presentationIn this case report, we demonstrate congenital microcephaly at week 19 of gestation in a 34-year-old mother who showed symptoms compatible with Zika virus infection from Sincelejo, State of Sucre, in the Colombian Caribbean. Zika virus RNA was detected in the placenta using real-time reverse transcriptase polymerase chain reaction (RT-PCR). At week 25, the fetus weigh estimate was 770 g, had a cephalic perimeter of 20.2 cm (5th percentile), ventriculomegaly on the right side and dilatation of the fourth ventricle. At week 32, the microcephaly was confirmed with a cephalic perimeter of 22 cm, dilatation of the posterior atrium to 13 mm, an abnormally small cerebellum (29 mm), and an augmented cisterna magna. At birth (39 weeks by cesarean section), the head circumference was 27.5 cm, and computerized axial tomography (Siemens Corp, 32-slides) confirmed microcephaly with calcifications.ConclusionWe report a first case of maternal Zika virus infection associated with fetal microcephaly in Colombia and confirmed similar presentation to those observed previous in Brazil, 2015–2016.

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Section: Introductionmentioning

confidence: 99%

Case report: microcephaly associated with Zika virus infection, Colombia

et al. 2017

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“…In Puerto Rico, the Zika Active Pregnancy Surveillance System was established to address specific needs resulting from the anticipated large outbreak (30). CDC also collaborated with the Instituto Nacional de Salud (National Institute of Health) in Colombia to conduct enhanced surveillance of pregnant women with symptomatic Zika virus disease in three cities (31). These surveillance systems continue to provide information about the magnitude of risk, the gestational timing of highest risk, and the spectrum of congenital Zika syndrome.…”

Section: Gathering and Analyzing Zika Pregnancy Surveillance Data To mentioning

confidence: 99%

Zika Virus —10 Public Health Achievements in 2016 and Future Priorities

Oussayef

Pillai

Honein

et al. 2017

MMWR Morb. Mortal. Wkly. Rep.

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“…The evidence-based causal relationship between Zika virus and microcephaly and other brain anomalies public health and economic impact calls for an urgent need to establish contextual and effective local and global neonatal-perinatal and postnatal longitudinal surveillance-response system policies and interventions implementation [1][2][3][11][12][13][14][15][16]. Enhancing robust laboratory data and information and analysis findings to appropriately define Zika viral infection syndrome pre, during and post pregnancy.…”

Section: Editorialmentioning

confidence: 99%

“…Strengthening Zika routine health system surveillance-response systems and research programs/projects is critical in prevention and control of pregnancy outcomes in prone settings and territories [6,9,10]. In addition, elucidating Aedes and sexual transmission related Zika virus transmission ecological, adaptation and human health threat and complications requires coordinated approach to data sharing, surveillance and research is needed in defining the full spectrum of congenital Zika virus syndrome and issues on maternal-child health [11][12][13]. Innovative approaches in Zika vaccines and therapeutic targets discovery and development should be explored coupled with in silico phylogenetics and phylogeography modelling in understanding its evidence about Zika virus infection congenital abnormalities public health threats [14,15].…”

mentioning

confidence: 99%

Zika Virus Linked Microcephaly and other Neurological Anomalies Epidemic on Neonatal-Perinatal Medicine: Perspective

Tambo¹

2017

Pediatric Infect Dis

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Preliminary Report of Microcephaly Potentially Associated with Zika Virus Infection During Pregnancy — Colombia, January–November 2016

Cited by 101 publications

References 7 publications

Case report: microcephaly associated with Zika virus infection, Colombia

Case report: microcephaly associated with Zika virus infection, Colombia

Zika Virus —10 Public Health Achievements in 2016 and Future Priorities

Zika Virus Linked Microcephaly and other Neurological Anomalies Epidemic on Neonatal-Perinatal Medicine: Perspective

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