Preliminary report of Iranian Registry of Alzheimer's disease in Tehran province: A cross‐sectional study in Iran

Fahanik‐Babaei, Javad; Sedighi, Mohsen; Mehrabi, Soraya; Pournik, Omid; Taheri, Abbas Sheikh; Kamalzadeh, Leila; Zarei, Mohammad; Roghani, Mehrdad; Golab, Fereshteh; Almasi, Mostafa; Etezadi, Afshin; Afshin‐Majd, Siamak; Malakouti, Seyed Kazem; Rajabi, Majid; Moghaddasi, Mehdi; Hajati, Gholamreza; Khamne, Fatemeh Golmohammadi; Jafari, Arzhang; Amanollahi, Alireza; Baluchnejadmojarad, Tourandokht

doi:10.1002/hsr2.952

Cited by 2 publications

(2 citation statements)

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“…The National Elderly Health Survey in Iran identified diabetes mellitus, depressed mood, illiteracy, and advanced age as significant risk factors for dementia [15]. Moreover, the Iranian Registry of Alzheimer's disease projected an increase in the number of individuals with dementia due to rising life expectancy and an expanding elderly population [31]. The variation of these risk factors across Iran's geographical regions may further contribute to the prevalence of dementia, underscoring the need for comprehensive strategies to address this growing public health concern.…”

Section: Discussionmentioning

confidence: 99%

Uncovering the extent of dementia prevalence in Iran: a comprehensive systematic review and meta-analysis

Oshnouei,

Safaralizade,

Eslamlou

et al. 2024

BMC Public Health

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Background Dementia is one of the major causes of disability and dependency among older people worldwide. The formation of an aging population in Iran can be associated with societal problems, including age-related disorders such as dementia. This study aimed to estimate the prevalence of dementia& Alzheimer disease in adults aged 60 years or older and it’s its geographical distribution in Iran. Methods A systematic review and meta-analysis study included articles published in both English and Persian languages and utilized various databases including: Google Scholar, PubMed, Web of Science, Magiran, and thesis database of medicine universities up to December 2022. The pooled prevalence was calculated using random effects models. The prevalence was reported separately for different geographical locations and types of area sampling, and age adjustment was performed for the selected studies. All statistical analyses were conducted using metaprop package in STATA version 17. The I2 statistic was applied to assess heterogeneity. Results The meta-analysis considered nine relevant studies that were carried out up to 2023 in Iran. The study found that the prevalence of dementia in central and east counties was estimated to be 0.14 (95% CI; 0.04–0.31), while in western counties, the prevalence was estimated to be 0.1 (95%CI; 0.01–0.27). The estimated overall crude prevalence of dementia was estimated at 0.14 (95% CI; 0.03–0.31). Estimated prevalence-based health centers sampling and hospital-based studies were 0.02 (95% CI; 0.02–0.03), 0.05 (95% CI 0.06–0.11), respectively. One study used nursing home sampling as the sampling method, and the estimated prevalence was 0.43 (95%CI 0.38–0.49). Conclusion This is the first systematic review and meta-analysis of the prevalence of dementia’s disease up to 2023 in Iran. The estimated overall prevalence of dementia is lower than the reported prevalence in European countries and similar to other Asian countries.

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Section: Discussionmentioning

confidence: 99%

Uncovering the extent of dementia prevalence in Iran: a comprehensive systematic review and meta-analysis

Oshnouei,

Safaralizade,

Eslamlou

et al. 2024

BMC Public Health

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“…AD is the most common type of dementia. The intense scientific interest in AD represents the high prevalence of this progressive neurodegenerative disorder ( Fahanik-Babaei et al, 2022 ). AD is identified by the progressive deprivation of memory and cognitive deficits ( Kumar and Singh, 2015 ; Naseri et al, 2022 ).…”

Section: Introductionmentioning

confidence: 99%

The synergic effects of presynaptic calcium channel antagonists purified from spiders on memory elimination of glutamate-induced excitotoxicity in the rat hippocampus trisynaptic circuit

Keimasi,

Salehifard,

Mirshah Jafar Esfahani

et al. 2023

Front. Mol. Biosci.

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The hippocampus is a complex area of the mammalian brain and is responsible for learning and memory. The trisynaptic circuit engages with explicit memory. Hippocampal neurons express two types of presynaptic voltage-gated calcium channels (VGCCs) comprising N and P/Q-types. These VGCCs play a vital role in the release of neurotransmitters from presynaptic neurons. The chief excitatory neurotransmitter at these synapses is glutamate. Glutamate has an essential function in learning and memory under normal conditions. The release of neurotransmitters depends on the activity of presynaptic VGCCs. Excessive glutamate activity, due to either excessive release or insufficient uptake from the synapse, leads to a condition called excitotoxicity. This pathological state is common among all neurodegenerative disorders, such as Alzheimer’s and Parkinson’s diseases. Under these conditions, glutamate adversely affects the trisynaptic circuitry, leading to synaptic destruction and loss of memory and learning performance. This study attempts to clarify the role of presynaptic VGCCs in memory performance and reveals that modulating the activity of presynaptic calcium channels in the trisynaptic pathway can regulate the excitotoxic state and consequently prevent the elimination of neurons and synaptic degradation. All of these can lead to an improvement in learning and memory function. In the current study, two calcium channel blockers—omega-agatoxin-Aa2a and omega-Lsp-IA—were extracted, purified, and identified from spiders (Agelena orientalis and Hogna radiata) and used to modulate N and P/Q VGCCs. The effect of omega-agatoxin-Aa2a and omega-Lsp-IA on glutamate-induced excitotoxicity in rats was evaluated using the Morris water maze task as a behavioral test. The local expression of synaptophysin (SYN) was visualized for synaptic quantification using an immunofluorescence assay. The electrophysiological amplitudes of the field excitatory postsynaptic potentials (fEPSPs) in the input-output and LTP curves of the mossy fiber and Schaffer collateral circuits were recorded. The results of our study demonstrated that N and P/Q VGCC modulation in the hippocampus trisynaptic circuit of rats with glutamate-induced excitotoxicity dysfunction could prevent the destructive consequences of excitotoxicity in synapses and improve memory function and performance.

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Preliminary report of Iranian Registry of Alzheimer's disease in Tehran province: A cross‐sectional study in Iran

Cited by 2 publications

References 40 publications

Uncovering the extent of dementia prevalence in Iran: a comprehensive systematic review and meta-analysis

Uncovering the extent of dementia prevalence in Iran: a comprehensive systematic review and meta-analysis

The synergic effects of presynaptic calcium channel antagonists purified from spiders on memory elimination of glutamate-induced excitotoxicity in the rat hippocampus trisynaptic circuit

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