Preliminary Report: Immunoperoxidase-Linked Human Placental Lactogen as a Histopathologic Index of Perinatal Morbidity and Mortality

Abstract

Anatomic study of placental dysfunction may benefit from the applications of new routine techniques. Immunohistochemical staining for human placental lactogen (HPL) was used in 3 cases illustrating different perinatal disorders. The amount of HPL labeling ranged from high in an acute anoxic death due to abruptio placentae, through decreased in a case of maternal hypertension, to low in severe intrauterine growth retardation. Such information complements standard clinical and pathologic studies. Ten percent buffered Formalin was superior to Bouin's fixative and alcoholic Formalin for the demonstration of HPL. Even after 4 days of refrigeration at 4 degrees C, all of the syncytiotrophoblastic tissue was labeled in sections of paraffin-embedded, Formalin-fixed normal placentas.

Molecular Changes on Maternal–Fetal Interface in Placental Abruption—A Systematic Review

“…As a result of the described procedure, 22 articles that met all the inclusion criteria were retrieved [ 20 , 21 , 27 , 29 , 38 , 39 , 40 , 41 , 42 , 43 , 44 , 45 , 46 , 47 , 48 , 49 , 50 , 51 , 52 , 53 , 54 , 55 ]. Extracted data included in this systematic review are collected in Table S2 .…”

“…The first studies concerning the problem were conducted over 30 years ago by Altshuler et al (1983) [ 38 ] concerning the elevated human placental lactogen levels in the placentas from placental abruption patients and by Ching et al (1987) [ 39 ] concerning the changes of opiate receptors in opiate users—a high placental abruption risk group. However, the available data are still scarce and even with a variety of studies, many questions still remain unanswered.…”