Preliminary report: imaging of Kaposi sarcoma and lymphoma in AIDS with indium-111-labelled liposomes

Lipid-Based Drug Delivery Systems in Cancer Therapy: What Is Available and What Is Yet to Come

“…In particular, Kaposi sarcoma demonstrated the highest level of 111 In uptake of all tumors investigated (Presant et al, 1990). It was suggested that the high uptake of 111 In in Kaposi sarcoma lesions might be due to their highly vascularized nature, which allowed small particles, such as liposomes, to extravasate readily (Wu et al, 1993;Brown et al, 1996).…”

“…In-based tumor imaging agent (VesCan), which could image a wide range of solid neoplasms (Presant et al, , 1990. In particular, Kaposi sarcoma demonstrated the highest level of 111 In uptake of all tumors investigated (Presant et al, 1990).…”

Positron Emission Tomography Based Elucidation of the Enhanced Permeability and Retention Effect in Dogs with Cancer Using Copper-64 Liposomes

“…Current knowledge on the EPR-effect in human tumors is based on studies of low-resolution single photon imaging techniques of radiolabeled liposomes. [15][16][17][18] Liposome uptake has been investigated in a Kaposi sarcoma and a lymphoma patient. 16 Furthermore, targeting and delineation has been investigated in eight high-grade gliomas 17 and positive tumor identification using radiolabeled phospholipid vesicles in 22 of 24 patients suffering from a few malignancies.…”

“…[15][16][17][18] Liposome uptake has been investigated in a Kaposi sarcoma and a lymphoma patient. 16 Furthermore, targeting and delineation has been investigated in eight high-grade gliomas 17 and positive tumor identification using radiolabeled phospholipid vesicles in 22 of 24 patients suffering from a few malignancies. 18 Gamma camera and single-photon emission computed tomography (SPECT) imaging of 111 In-DTPA-labeled pegylated liposomes was also performed in 17 patients suffering from head and neck, breast, bronchus and cervix cancer and two glioma patients, with 12 tumors being identified by gamma camera imaging and 15 tumors identified by SPECT.…”

Liposomally targeted cytotoxic drugs for the treatment of cancer

“…Imaging studies using radiolabelled liposomes composed of DSPC and cholesterol have con® rmed the ability of this formulation to target a range of solid and haematological tumours (Presant et al , 1990Turner et al 1988 ;Gabizon et al 1991 ;Kubo et al 1993 ;Khalifa et al 1997). Kubo et al (1993) injected 111 In-nitrilotriacetic acid (NTA)-labelled liposomes containing 37 MBq of radioactivity into seven patients with breast (n¯2), colonic (n¯2), lung (n¯1) and prostate cancers (n¯1), and lymphoma (n¯1).…”