Preliminary report: A serious link between adiponectin levels and metabolic syndrome in a Korean nondiabetic population

Koh, Sang Back; Park, Jong Ku; Yoon, Jin Ha; Chang, Sei Jin; Oh, Sung Soo; Kim, Jang Young; Ryu, So Yeon; Kim, Ki Soon; Lee, Tae Yong; You, Joshua H.

doi:10.1016/j.metabol.2009.07.031

Cited by 28 publications

(22 citation statements)

References 14 publications

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“…Subjects in our study had mean baseline adiponectin concentrations of 2.0±0.4 mg/L, which are comparable to previously reported studies in which subjects in the lowest quartile of adiponectin (< 5.0 mg/L) had highest incidence or risks of metabolic syndrome [70, 71]. Green tea catechins have been shown to up regulate adiponectin expression in mouse preadipocyte cells [72].…”

Section: Discussionsupporting

confidence: 87%

Green tea minimally affects biomarkers of inflammation in obese subjects with metabolic syndrome

et al. 2011

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Objective Green tea (Camellia sinensis) has shown to exert cardio-protective benefits in observational studies. The objective of this clinical trial was to assess the effects of green tea on features of metabolic syndrome and inflammation in obese subjects. Methods We conducted a randomized controlled trial in obese subjects with metabolic syndrome. Thirty-five subjects [age (mean±SE) 42.5±1.7 years, BMI 36.1±1.3 kg/m2] completed the 8-week study and were randomly assigned to receive green tea (4 cups/day), green tea extract (2 capsules and 4 cups water/day), or no treatment (4 cups water/day). Both the beverage and extract groups had similar dosing of epigallocatechin-3-gallate (EGCG), the active green tea polyphenol. Fasting blood samples were collected at screening, four, and eight weeks of the study. Results Green tea beverage or extract supplementation did not significantly alter features of metabolic syndrome or biomarkers of inflammation including adiponectin, C-reactive protein (CRP), interleukin-6 (IL-6), interleukin-1β (IL-1β), soluble vascular cell adhesion molecule-1 (sVCAM-1), soluble intercellular adhesion molecule-1 (sICAM-1), leptin, or leptin:adiponectin ratio. However, both green tea beverage and extracts significantly reduced plasma serum amyloid alpha (SAA) versus no treatment (p<0.005). Conclusion This study suggests that the daily consumption of green tea beverage or extracts for 8 weeks was well tolerated but did not affect the features of metabolic syndrome. However, green tea significantly reduced plasma SAA, an independent CVD risk factor, in obese subjects with metabolic syndrome.

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Section: Discussionsupporting

confidence: 87%

Green tea minimally affects biomarkers of inflammation in obese subjects with metabolic syndrome

et al. 2011

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“…First, this study included middle-aged and elderly people living in rural settings with proportionately higher cases of metabolic syndrome [14]. Nonetheless, our cohort observed a similar pattern in the prevalence of metabolic syndrome to that of the Korean National Health and Nutrition Examination Survey (KNHANES) [12, 40, 41]. Moreover, the lifestyle change in Korea towards the Western pattern seems to be the primary cause for the increasing risk of metabolic syndrome.…”

Section: Discussionmentioning

confidence: 85%

“…Our study data were collected from the Korean Genome and Epidemiology Study (KoGES), an ongoing multicenter prospective cohort study designed to estimate the prevalence, incidence, and risk factors related with many disorders such as diabetes, hypertension, and cardiovascular disease [12–14]. The study enrolled adults in the rural region of Wonju and Pyeongchang in South Korea.…”

Section: Methodsmentioning

confidence: 99%

Incremental Predictive Value of Serum AST-to-ALT Ratio for Incident Metabolic Syndrome: The ARIRANG Study

et al. 2016

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AimsThe ratio of aspartate aminotransferase (AST) to alanine aminotransferase (ALT) is of great interest as a possible novel marker of metabolic syndrome. However, longitudinal studies emphasizing the incremental predictive value of the AST-to-ALT ratio in diagnosing individuals at higher risk of developing metabolic syndrome are very scarce. Therefore, our study aimed to evaluate the AST-to-ALT ratio as an incremental predictor of new onset metabolic syndrome in a population-based cohort study.Material and MethodsThe population-based cohort study included 2276 adults (903 men and 1373 women) aged 40–70 years, who participated from 2005–2008 (baseline) without metabolic syndrome and were followed up from 2008–2011. Metabolic syndrome was defined according to the harmonized definition of metabolic syndrome. Serum concentrations of AST and ALT were determined by enzymatic methods.ResultsDuring an average follow-up period of 2.6-years, 395 individuals (17.4%) developed metabolic syndrome. In a multivariable adjusted model, the odds ratio (95% confidence interval) for new onset of metabolic syndrome, comparing the fourth quartile to the first quartile of the AST-to-ALT ratio, was 0.598 (0.422–0.853). The AST-to-ALT ratio also improved the area under the receiver operating characteristic curve (AUC) for predicting new cases of metabolic syndrome (0.715 vs. 0.732, P = 0.004). The net reclassification improvement of prediction models including the AST-to-ALT ratio was 0.23 (95% CI: 0.124–0.337, P<0.001), and the integrated discrimination improvement was 0.0094 (95% CI: 0.0046–0.0143, P<0.001).ConclusionsThe AST-to-ALT ratio independently predicted the future development of metabolic syndrome and had incremental predictive value for incident metabolic syndrome.

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“…[20–22]. Accordingly, the level of adiponectin is associated with obesity-related disorders and metabolic risk factors [23–26]. Adiponectin levels are inversely correlated with visceral obesity; therefore, high levels of adiponectin are negative correlated with obesity whereas low adiponectin levels exhibit a positive correlation 9 .…”

Section: Introductionmentioning

confidence: 99%

Visceral Fat Area and Serum Adiponectin Level Predict the Development of Metabolic Syndrome in a Community-Based Asymptomatic Population

et al. 2017

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BackgroundAlthough it has been demonstrated that visceral adipose tissue content and serum levels of adiponectin are associated with metabolic syndrome, their predictive potential for the development of metabolic syndrome remains to be elucidated.MethodsWe studied 1,130 participants of the Seoul Metabolic Syndrome cohort. A total of 337 subjects without metabolic syndrome underwent the follow-up evaluation and finally analyzed. Visceral fat area (VFA) was measured using dual bioelectrical impedance analysis. We compared the 1-year incidence rate of metabolic syndrome among four different groups: Group 1 (high adiponectin level and low VFA), Group 2 (low adiponectin level and low VFA), Group 3 (high adiponectin level and high VFA) and Group 4 (low adiponectin level and high VFA).ResultsMedian follow-up duration was 17 months. Cut-off points of adiponectin level and VFA for metabolic syndrome were 7.34 ng/ml and 84 cm2 for men, and 12.55 and 58 cm2 ng/ml for women, respectively. The incidence of metabolic syndrome was the highest in Group 4 (Group 1; 16.47%, Group 2; 22.08%, Group 3; 25%, and Group 4; 46.15%, p<0.001). Adjusted logistic regression analyses for metabolic syndrome prediction demonstrated that Group 4 exhibited the highest odds ratio compared with Group 1 (4.918 [2.05–11.795]), which was predominantly affected by waist circumference and serum triglyceride levels. Notably, triglyceride/high-density lipoprotein cholesterol (TG/HDL) ratio was significantly higher in Group 4 (p = 0.017).ConclusionIncidence rate of metabolic syndrome was the highest in subjects with low serum adiponectin levels and high visceral fat area. Higher TG/HDL ratio in these subjects suggested insulin resistance may contribute to the development of metabolic syndrome.

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Preliminary report: A serious link between adiponectin levels and metabolic syndrome in a Korean nondiabetic population

Cited by 28 publications

References 14 publications

Green tea minimally affects biomarkers of inflammation in obese subjects with metabolic syndrome

Green tea minimally affects biomarkers of inflammation in obese subjects with metabolic syndrome

Incremental Predictive Value of Serum AST-to-ALT Ratio for Incident Metabolic Syndrome: The ARIRANG Study

Visceral Fat Area and Serum Adiponectin Level Predict the Development of Metabolic Syndrome in a Community-Based Asymptomatic Population

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