Preliminary quantitative proteomics analysis in chronic and latent Keshan disease by iTRAQ labeling approach

Sun, Yuxiao; Gao, Chuanyu; Wang, Xianqing; Wang, Kun

doi:10.18632/oncotarget.22397

Cited by 7 publications

(4 citation statements)

References 31 publications

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“…Myocardial apoptosis is one of the primary pathological changes seen in KD [14], but the molecular mechanisms underlying this dysfunction, have not been fully elucidated. In this study, we found that the apoptosis-related gene BCL2-like-1 ( BCL2L1 ) was significantly upregulated in patients.…”

Section: Discussionmentioning

confidence: 99%

Expression Profile Analysis of Selenium-Related Genes in Peripheral Blood Mononuclear Cells of Patients with Keshan Disease

Liu

Peng

et al. 2019

BioMed Research International

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Keshan disease (KD) is an endemic cardiomyopathy, which mainly occurs in China. Selenium deficiency is believed to play an important role in the pathogenesis of KD, but the molecular mechanism of selenium-induced damage remains unclear. To identify the key genes involved in selenium-induced damage, we compared the expression profiles of selenium-related genes between patients with KD and normal controls. Total RNA was isolated, amplified, labeled, and hybridized to Agilent human 4 × 44 K whole genome microarrays. Selenium-related genes were screened using the Comparative Toxicogenomics Database. The microarray data were subjected to single-gene and gene ontology (GO) expression analysis using R Studio and Gene Set Enrichment Analysis (GSEA) software. Quantitative real-time PCR was conducted to validate the microarray results. We identified 16 upregulated and 11 downregulated selenium-related genes in patients. These genes are involved in apoptosis, metabolism, transcription regulation, ion transport, and growth and development. Of the significantly enriched GO categories in KD patients, we identified four apoptosis-related, two metabolism-related, four growth and development-related, and four ion transport-related GOs. Based on our results, we suggest that selenium might contribute to the development of KD through dysfunction of selenium-related genes involved in apoptosis, metabolism, ion transport, and growth and development in the myocardium.

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Section: Discussionmentioning

confidence: 99%

Expression Profile Analysis of Selenium-Related Genes in Peripheral Blood Mononuclear Cells of Patients with Keshan Disease

Liu

Peng

et al. 2019

BioMed Research International

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“…The first cases of Keshan disease (KD) were discovered over 80 years ago in Keshan County (Heilongjiang Province, north-eastern China) [ 60 ]. The disease was characterized by congestive cardiomyopathy and affected children aged 2–7 years and women of reproductive age [ 61 ], whereas Kashin-Beck disease (KBD) occurs most frequently in Tibet [ 62 ] and begins in childhood around age five [ 63 , 64 ]. KBD is characterized by osteoarthritis, leading to the degradation of cartilage in the upper and lower limbs [ 63 ].…”

Section: Dietary Intake Of Seleniummentioning

confidence: 99%

Selenium as a Bioactive Micronutrient in the Human Diet and Its Cancer Chemopreventive Activity

et al. 2021

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This review answers the question of why selenium is such an important trace element in the human diet. Daily dietary intake of selenium and its content in various food products is discussed in this paper, as well as the effects of its deficiency and excess in the body. Moreover, the biological activity of selenium, which it performs mainly through selenoproteins, is discussed. These specific proteins are responsible for thyroid hormone management, fertility, the aging process, and immunity, but their key role is to maintain a redox balance in cells. Furthermore, taking into account world news and the current SARS-CoV-2 virus pandemic, the impact of selenium on the course of COVID-19 is also discussed. Another worldwide problem is the number of new cancer cases and cancer-related mortality. Thus, the last part of the article discusses the impact of selenium on cancer risk based on clinical trials (including NPC and SELECT), systematic reviews, and meta-analyses. Additionally, this review discusses the possible mechanisms of selenium action that prevent cancer development.

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“…The onset is slower than that of acute KD, and patients may suffer congestive heart failure or cardiogenic shock shortly after onset. Subacute KD often occurs in children from 2 to 5 years of age ( 86 ). The symptoms may be similar to those of common cardiac hypertrophy and marked heart expansion, but myocardial necrosis is not as severe and common as that of acute KD.…”

Section: Clinical Manifestationsmentioning

confidence: 99%

Keshan Disease: A Potentially Fatal Endemic Cardiomyopathy in Remote Mountains of China

et al. 2021

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Keshan disease (KD) as an endemic, highly lethal cardiomyopathy, first reported in northeast China's Keshan County in 1935. The clinical manifestations of patients with KD include primarily congestive heart failure, acute heart failure, and cardiac arrhythmia. Even though some possible etiologies, such as viral infection, fungal infection, microelement deficiency, and malnutrition, have been reported, the exact causes of KD remain poorly known. The endemic areas where KD is found are remote and rural, and many are poor and mountainous places where people are the most socioeconomically disadvantaged in terms of housing, income, education, transportation, and utilization of health services. To date, KD is a huge burden to and severely restricts the economic development of the local residents and health systems of the endemic areas. Although efforts have been made by the government to control, treat, and interrupt disease transmission, the cure for or complete eradication of KD still requires global attention. For this reason, in this review, we systematically describe the etiological hypothesis, clinical manifestations, incidence characteristics, and treatment of KD, to facilitate the better understanding of and draw more attention to this non-representative cardiovascular disease, with the aim of accelerating its elimination.

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Preliminary quantitative proteomics analysis in chronic and latent Keshan disease by iTRAQ labeling approach

Cited by 7 publications

References 31 publications

Expression Profile Analysis of Selenium-Related Genes in Peripheral Blood Mononuclear Cells of Patients with Keshan Disease

Expression Profile Analysis of Selenium-Related Genes in Peripheral Blood Mononuclear Cells of Patients with Keshan Disease

Selenium as a Bioactive Micronutrient in the Human Diet and Its Cancer Chemopreventive Activity

Keshan Disease: A Potentially Fatal Endemic Cardiomyopathy in Remote Mountains of China

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