Preliminary Phytochemical Screening, Evaluation of the Phenolic Compositions and Antioxidant Activities of Four Iranian Alyssum Species

Golkar, Pooran; Fotoohi, Ahmad; Frezza, Claudio

doi:10.2174/1573407215666190215152137

Cited by 3 publications

(1 citation statement)

References 24 publications

Supporting

Mentioning

Contrasting

Order By: Relevance

“…as well as gas chromatography (GC) or GC-MS analysis, phytochemical screening such as total flavonoid content (TFC), total phenolic content (TPC), etc., and antioxidant potential tests such as 2,2-dipehnyl-1-picrylhydrazyl (DPPH), etc. [ 97 , 98 , 99 , 100 , 101 , 102 , 103 , 104 , 105 , 106 , 107 ]. Solid-liquid extraction (SLE) is one of the main methods for extraction of phenolic compounds, specially syringic acid, catechin, and p -coumaric acid, which is simple, well established, and widely used [ 108 ].…”

Section: Introductionmentioning

confidence: 99%

Therapeutic Potential of Phenolic Compounds in Medicinal Plants—Natural Health Products for Human Health

2023

View full text Add to dashboard Cite

Phenolic compounds and flavonoids are potential substitutes for bioactive agents in pharmaceutical and medicinal sections to promote human health and prevent and cure different diseases. The most common flavonoids found in nature are anthocyanins, flavones, flavanones, flavonols, flavanonols, isoflavones, and other sub-classes. The impacts of plant flavonoids and other phenolics on human health promoting and diseases curing and preventing are antioxidant effects, antibacterial impacts, cardioprotective effects, anticancer impacts, immune system promoting, anti-inflammatory effects, and skin protective effects from UV radiation. This work aims to provide an overview of phenolic compounds and flavonoids as potential and important sources of pharmaceutical and medical application according to recently published studies, as well as some interesting directions for future research. The keyword searches for flavonoids, phenolics, isoflavones, tannins, coumarins, lignans, quinones, xanthones, curcuminoids, stilbenes, cucurmin, phenylethanoids, and secoiridoids medicinal plant were performed by using Web of Science, Scopus, Google scholar, and PubMed. Phenolic acids contain a carboxylic acid group in addition to the basic phenolic structure and are mainly divided into hydroxybenzoic and hydroxycinnamic acids. Hydroxybenzoic acids are based on a C6-C1 skeleton and are often found bound to small organic acids, glycosyl moieties, or cell structural components. Common hydroxybenzoic acids include gallic, syringic, protocatechuic, p-hydroxybenzoic, vanillic, gentistic, and salicylic acids. Hydroxycinnamic acids are based on a C6-C3 skeleton and are also often bound to other molecules such as quinic acid and glucose. The main hydroxycinnamic acids are caffeic, p-coumaric, ferulic, and sinapic acids.

show abstract

Section: Introductionmentioning

confidence: 99%

Therapeutic Potential of Phenolic Compounds in Medicinal Plants—Natural Health Products for Human Health

2023

View full text Add to dashboard Cite

show abstract

Antimicrobial and Antifungal Properties of Leaves to Root Extracts and Saponin Fractions of Chlorophytum borivilianum

Sharma¹,

Singh²,

Sanjeev

et al. 2021

CBC

View full text Add to dashboard Cite

Objective: 1. To examine the antimicrobial activity of methanolic crude extract from different parts of the Chlorophytum borivilianum plant against pathogenic microorganisms. 2. Assessment of antimicrobial activity by MIC and structural characterization of purified saponin of Chlorophytum borivilianum by using spectrophotometric and NMR analysis. Methods: The antimicrobial analysis of the extracts of leaves, roots and stems of C. borivilianum are based on the agar well diffusion method and minimum inhibitory concentration (MIC). The phytochemical screening and characterization of saponin on the basis of structural and antimicrobial activity present in C. borivilianum were analyzed by different spectrophotometric methods such as HPLC, UV-visible, IR, NMR, LC-ESI-MS and pharmacophore modeling. Results: The results revealed that the methanolic leaf, stem and root extracts have inhibitory potential against the growth of K. pneumonia, B. subtilis, M. tuberculosis, E coli and S aureus in case of bacteria and C. albicans, A. fumigatus and Tricoderma in case of fungus. The MIC of leaf, stem and root extracts were found in the range of 1 mg/ml to 0.125 mg/ml. Moreover, the purified saponins indicate MIC in the range of 0.5 mg/ml to 0.0625 mg/ml against the selected microbial pathogens. Saponins act as one of the major phyto-component presents in C. borivilianum.The antimicrobial and structural analysis of purified saponins of C. borivilianum were also performed using different spectral analysis methods. Conclusion: The anti-microbial results showed that the extract from the leaf and stems have higher anti-pathogenic activity as compared to the roots. The MIC results show that the purified saponin also possesses the anti-microbial activity and oleanolic acid content as detected by spectral analysis, is the fundamental structure of the extracted saponin.

show abstract

Bioactive Compound and Nanotechnology: A Novel Delivery Perspective for Diabetic Retinopathy

Debbarma¹,

Probin²,

Samia³

et al. 2021

CBC

View full text Add to dashboard Cite

Background: Diabetic retinopathy (DR) is one of the major complications of diabetes and the consequences often lead to loss of vision. Currently, the treatments for DR are expensive, not easily available and use of synthetic drugs leads to various toxic effects. Bioactive compound has been reported to be an alternative for treatment of DR due to its ability to target multiple pathophysiological signaling pathways. However, bioactive compound suffers from some inherent physicochemical characteristics which restricts their use as therapeutic agents. Objective: This review emphasizes on an overview of the bioactive agents which are delivered as nano-formulation for safe and effective ocular delivery for the treatment of DR. Additional focus include site specific ocular delivery with increased bioavailability to ensure highly efficacious treatment of DR. Results: Utilization of various bioactive compounds such as polyphenols, flavonoids, tannins etc. can counter balance the damages occurs in the retinal tissues and thereby may ameliorate DR progression. Encapsulation of these bioactive compounds in nanotechnology-based delivery system can improve the bioavailability, reduce toxic effect and achieve sitespecific ocular delivery. Conclusion: The pros and cons of bioactive compounds in treating DR and the use of nanotechnology to deliver bioactive compounds are discussed.

show abstract

Preliminary Phytochemical Screening, Evaluation of the Phenolic Compositions and Antioxidant Activities of Four Iranian Alyssum Species

Cited by 3 publications

References 24 publications

Therapeutic Potential of Phenolic Compounds in Medicinal Plants—Natural Health Products for Human Health

Therapeutic Potential of Phenolic Compounds in Medicinal Plants—Natural Health Products for Human Health

Antimicrobial and Antifungal Properties of Leaves to Root Extracts and Saponin Fractions of Chlorophytum borivilianum

Bioactive Compound and Nanotechnology: A Novel Delivery Perspective for Diabetic Retinopathy

Contact Info

Product

Resources

About