Preliminary Phytochemical Screening and in-Vitro Free Radical Scavenging Activity of Root Extracts of Glycyrrhiza Glabra L

Sakthi, Archana

doi:10.22159/ajpcr.2016.v9i6.13675

Cited by 4 publications

(4 citation statements)

References 21 publications

(21 reference statements)

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“…Further, proteins, terpenoids, and tannins presence were found in methanol, chloroform, and aqueous extracts, respectively. Plant terpenoids are used extensively for their aromatic qualities and play a role in traditional herbal remedies [32].…”

Section: Bashyal and Guhamentioning

confidence: 99%

Evaluation of Trachyspermum Ammi Seeds for Antimicrobial Activity and Phytochemical Analysis

Bashyal

Guha

2018

Asian J Pharm Clin Res

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Objective: The objective of this study is to identify medicinally important phytochemicals and evaluate the antimicrobial potential of Trachyspermum ammi seeds. Methods:Four different extracts (methanol, acetone, chloroform, and water) were prepared using a soxhlet apparatus, antimicrobial activity was tested using agar well-diffusion technique. Results:The results revealed the presence of flavonoids and saponins in all the extracts prepared. Similarly, alkaloids and phenols presence were obtained in methanol and aqueous extracts. Glycosides and carbohydrates in methanol, chloroform, and aqueous extracts. Further, proteins, terpenoids, and tannins presence were found in methanol, chloroform, and aqueous extracts, respectively. The maximum zone of inhibition was found in the methanolic extract (13.5 mm). Acetone, chloroform, and water extracts showed 9 mm, 10.5 mm, 11 mm respectively, while ciprofloxacin (control) showed 17.5 mm of the zone of inhibition. Conclusion:T. ammi seeds exert biological properties due to the presence of various chemical constituents. Thus, it can be used to obtain novel antibacterial compounds for the treatment of infectious diseases in the future.

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Section: Bashyal and Guhamentioning

confidence: 99%

Evaluation of Trachyspermum Ammi Seeds for Antimicrobial Activity and Phytochemical Analysis

Bashyal

Guha

2018

Asian J Pharm Clin Res

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“…A filtered sample(extract) was collected, dried well and stored. The extract was then subjected to phytochemical testing to identify the presence of alkaloids, saponins, flavonoids, steroids, glycosides and phenols [4].…”

Section: Sample Collection and Extractionmentioning

confidence: 99%

“…Licorice is widely used for its anti-ulcer activity, and it is taken orally for various digestive system complaints, including stomach ulcers, heartburn, colic, and ongoing inflammation of the lining of the stomach (chronic gastritis). It mainly contains glycyrrhizin, flavonoids such as liquiritin and isoliquiritin and steroids such as β-sitosterol, which is responsible for the antiulcer activity [4]. These constituents decrease swelling, thin mucus secretions, decrease cough, and increase the chemicals in our body that heal ulcers [5,6].…”

Section: Introductionmentioning

confidence: 99%

Formulation and Characterisation of Gastroretentive in Situ Gel Loaded With Glycyrrhiza Glabra L. Extract for Gastric Ulcer

R.,

PRIYA,

JYOTHI

et al. 2024

Int J App Pharm

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Objective: The study aimed to formulate and evaluate the gastroretentive in situ gelling system of Glycyrrhiza glabra L. extract to increase the gastric residence time and provide sustained release of the drug, thereby avoiding disadvantages such as frequent dosing, patient non-compliance and low bioavailability. Methods: The in-situ gel was prepared by pH-triggered gelation method by using sodium alginate and gellan gum as polymers, sodium citrate as a crosslinking agent, and calcium carbonate as a floating agent. Formulation and optimization of in situ gels were achieved by 32 factorial design by using Design-Expert Software to determine the influence of independent variables such as concentration of sodium alginate and gellan gum on viscosity, gel strength, the onset of flotation, and drug release at 12 h. Results: The viscosity, gel strength, onset of flotation and drug release at 12h of optimized formulation were found to be 568.89 cps, 42.91 sec, 53.17 sec and 82.69%, respectively. The floating duration of all in-situ gels was found to be more than 12 h. All the formulations showed drug content in the range of 83.55% to 95.28%. The in vitro release profile of the drug extract from all the formulations appeared to follow the Higuchi model, which concludes that the drug release was controlled by diffusion mechanism. The FTIR study indicates no chemical incompatibility between drug extract and other excipients. Conclusion: Hence, a novel gastroretentive in situ gelling system of Glycyrrhiza glabra L. could be prepared for sustained oral delivery to increase patient compliance with reduced dosing frequency and increased residence time of the drug in the stomach.

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“…0.5 of the H2SO4 solution was removed and discarded; 0.5ml of the BaCl2 solution was taken and added to the H2SO4 solution to make the McFarland standard. The 0.5 McFarland standard turbidity solutions correspond to a homogenous Escherichia coli suspension of 1.5 × 10 8 cells/ml [11] .…”

Section: Preparation Of 05 Mcfarland Standard Turbidity Solutionsmentioning

confidence: 99%

Phytochemical screening and antibacterial activities of cassia fistula leaf extracts on some selected pathogens

Shehu¹,

Ag²,

Adetoyinbo³

et al. 2020

J Pharmacogn Phytochem

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Cassia fistula, commonly known as golden shower tree has for long been used for treatment of number of ailment as decoction from its leaves by many. This study was carried out with the aim to evaluate the antibacterial activity and investigate the phytochemical properties of the leaves of Cassia fistula plant. Hot water, cold water and ethanol extracts of leaves of Cassia fistula were examined against medically important bacteria (Staphylococcus aureus, Escherichia coli, Pseudomonas aeruginosa, Klebsiella pneumonia and Salmonella typhi) by agar disc diffusion method using different extracts concentration. There was a remarkable inhibition of the bacterial growth against all tested organisms with highest activity seen at 100µg/ml for all the hot water, cold water and ethanol extract. Phytochemical analysis was carried out to determine the phytochemical constituents present in the leaf. Phytochemical screening revealed the presence of capric acid, palmitic acid, oleic acid, 1, E-11, Z-13-octadriene, 9-octadecenal, brassidic acid. The result from this study is an indication that Cassia fistula leaf is effective against these pathogens and can be further exploited for the development of new antimicrobials.

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Preliminary Phytochemical Screening and in-Vitro Free Radical Scavenging Activity of Root Extracts of Glycyrrhiza Glabra L

Cited by 4 publications

References 21 publications

Evaluation of Trachyspermum Ammi Seeds for Antimicrobial Activity and Phytochemical Analysis

Evaluation of Trachyspermum Ammi Seeds for Antimicrobial Activity and Phytochemical Analysis

Formulation and Characterisation of Gastroretentive in Situ Gel Loaded With Glycyrrhiza Glabra L. Extract for Gastric Ulcer

Phytochemical screening and antibacterial activities of cassia fistula leaf extracts on some selected pathogens

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