Preliminary Phytochemical Screening and Antimicrobial Activities of Some Medicinal Plants Used In Ebiraland

Alli, AI; Ehinmidu, JO; Ibrahim, YKE

doi:10.4314/bjpas.v4i1.2

Cited by 7 publications

(8 citation statements)

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“…As shown by the present study, the significant antibacterial activity of ethanol extracts of the two plants against E. coli is an indication of their therapeutic potential in management of UTI. Results obtained in this work agree with the findings of previous authors on antimicrobial status of P. amarus (Alli et al, 2011;Eldeen et al, 2011;Njoroge et al, 2012). Although, there is scarcity of information on the antimicrobial activity of P. niruri in the literature, it has been reported to be effective against hepatitis B and other viral infections (Bhattacharjee and Sil, 2006;Bhattacharjee and Sil, 2007).…”

Section: Discussionsupporting

confidence: 93%

Antibacterial attributes of extracts of Phyllantus amarus and Phyllantus niruri on Escherichia coli the causal organism of urinary tract infection

Gbadamosi¹

2015

J. Pharmacognosy Phytother.

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In view of the prevalence of urinary tract infection (UTI) worldwide, the increasing resistance of pathogenic bacteria to conventional antibiotics and their side effects, the aerial part and root of Phyllanthus amarus (Schum. and Thonn.) and Phyllanthus niruri (L.) were analysed for mineral and phytochemical constituents, and their ethanol extracts screened against five clinical isolates of Escherichia coli associated with UTI, to ascertain their effectiveness in UTI treatment, and provide basis for future clinical trials of the two plants. The isolates (10-1 × 10-6 cfu/ml) were tested against ethanol extracts (10 mg/ml) of plant parts using agar well diffusion method. Phytochemical and mineral analyses of the plant samples were done using standard protocols and all data were statistically analysed. The quantities of various phytochemical compounds and minerals were significantly (P<0.05) higher in P. niruri than P. amarus. At 10-6 cfu/ml inoculum concentration of all isolates, the inhibitory activities of extracts of P. amarus and P. niruri were the same, and significant (P<0.05) against isolates EC01, EC02, EC04 and EC05 compared to the control experiment. The inhibitory pattern varied against EC03, extract B (29.00 mm) was the most active, followed by extract C (24.00 mm), and extracts A and D gave the same diameter (19.00 mm) of inhibition. The two plants showed significant antibacterial activity against isolates and could be good alternatives to chemical antibiotics in the treatment of E. coli related UTI, however the mechanism of action of the plant extracts in treatment should be investigated.

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Section: Discussionsupporting

confidence: 93%

Antibacterial attributes of extracts of Phyllantus amarus and Phyllantus niruri on Escherichia coli the causal organism of urinary tract infection

Gbadamosi¹

2015

J. Pharmacognosy Phytother.

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“…Many of the infectious diseases are still a major challenge to health issues all over the world. The emergence of resistance to antibiotics has further compounded the problem (Alli et al, 2011). The need for new antimicrobial compounds has become imperative.…”

Section: Resultsmentioning

confidence: 99%

Phytochemical screening and comparative analysis of antimicrobial activity of root and leaf extracts of Tinospora coridifolia, Phyllanthus niruri and Abrus precatorious, important medicinal plants

Gawai¹,

Das²,

Rout³

2013

J. Med. Plants Res.

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Medicinal plants have been a basic source of antibiotics against a variety of diseases over the years. This study was carried out to investigate the antibacterial and antifungal activities of the ethanolic extracts of Tinospora cordifolia Miers. Phyllanthus niruri L. and Abrus precatorious L. against the pathogenic Escherichia coli and fungi Aspergillus niger and Epidermophyton floccosum by the filter paper disc method. Among the three plant extracts tested, T. cordifolia leaf extract showed maximum zone of inhibition of 24.0 mm against the bacteria E. coli at the concentration of 100 mg/ml. Extract of P. niruri exhibited similar inhibition zone against the bacterium, that is, 22.0 mm. A. precatorius leaf extract showed no inhibition. Increase in the concentration of plant extract increased the zone of inhibition. The root extract of A. precatorius showed significant inhibition against the fungi in comparison with other plant extracts. This study validates the use of tested medicinal plants in the treatment of various diseases.

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“…Numerous studies have been carried out to extract various natural products for screening antimicrobial activity [1] . It has been estimated that between 60-90% of population in developing countries use traditional and botanical medicines exclusively and consider them to be a normal part of primary healthcare [2] . Consumers are increasingly interested in complementary and alternative medicine, including herbal medicine, as they perceive these forms of healing as being both safe and effective.…”

Section: Introductionmentioning

confidence: 99%

In vitro analysis on bactericidal screening and antioxidant potentiality of leaf and root extracts of Thottea siliquosa (Lam.) Ding Hou. An ethnobotanical plant

Nusaiba¹,

Murugan

2013

Asian Pacific Journal of Tropical Biomedicine

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Objective: Natural products of plant origin are potential source of novel antimicrobial and antioxidative agents. Thottea siliquosa (Lam.) Ding Hou. (T. siliquosa). A medicinal herb used by local tribals for treating various ailments. The present study aims at the phytochemical screening, GC-MS analysis, in vitro antibacterial activity and antioxidant potentiality of root and leaf extracts of T. siliquosa. Methods: Hot continuous Soxhlet extraction, GC-MS analysis, antibacterial analysis by disc diffusion, microdilution assay and antioxidant potentialities by hydroxyl radical and nitric oxide radical scavenging. The data was statistically analyzed. Results: Phytochemical screening of the ethyl acetate and methanolic extract of leaf and root revealed the presence of phenols, alkaloids, tannins and saponin. The extract revealed a pool of phytochemicals by comparison with authentic standards from spectral library. Both the extracts has shown their broad spectrum of inhibition against the selected bacteria Staphylococcus aureus, Escherichia coli, Pseudomonas aeruginosa and Klebsiella pneumonia compared with standard antibiotic drug streptomycin. The extracts showed antioxidant activity by scavenging of free radicals such as hydroxyl and nitric oxide. The IC 50 values of the ethyl acetate extracts leaf and root and standard in this assay were 167.5依0.67, 99.4依1.2, 192依2.5 µg/mL respectively. Similarly those methanolic extracts of leaf and root were 269.5依0.89 and 289.1依2.66 µg/mL respectively. Similarly, ethyl acetate and methanolic extracts also caused a moderate dose-dependent inhibition of nitric oxide with an IC 50 range 65.5依1.55 to 148 依3.09 µg/mL. The inhibitory activities were found to be dose dependent. Conclusion: The present study provides evidence that ethyl acetate and methanol extract of leaf and root of T. siliquosa are potential source of natural antioxidants and bactericidal nature. It is essential that research should continue to isolate and purify the bio active components of this natural plant and use in drug discovery and development.

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Preliminary Phytochemical Screening and Antimicrobial Activities of Some Medicinal Plants Used In Ebiraland

Cited by 7 publications

References 0 publications

Antibacterial attributes of extracts of Phyllantus amarus and Phyllantus niruri on Escherichia coli the causal organism of urinary tract infection

Antibacterial attributes of extracts of Phyllantus amarus and Phyllantus niruri on Escherichia coli the causal organism of urinary tract infection

Phytochemical screening and comparative analysis of antimicrobial activity of root and leaf extracts of Tinospora coridifolia, Phyllanthus niruri and Abrus precatorious, important medicinal plants

In vitro analysis on bactericidal screening and antioxidant potentiality of leaf and root extracts of Thottea siliquosa (Lam.) Ding Hou. An ethnobotanical plant

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