Preliminary phytochemical and antimicrobial screening of the leaves of &lt;i&gt;Byrsocarpus coccineus&lt;/i&gt; Schum &amp; Thonn (Connaraceae)

Ahmadu, AA; ., I.N. Akpulu; Hassan, Halima S.; Sule, Mohammed I.; Pateh, U. U.

doi:10.4314/jpb.v3i2.32104

Cited by 14 publications

(21 citation statements)

References 7 publications

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“…Furthermore, the significantly analgesic, anti-inflammatory and antipyretic effects of the leaf extract support the fact that the inhibition of prostaglandins might also be a possible mechanism for its ulcer protective activity [9,12]. Moreover, an agent which is highly effective in preventing ethanol-induced gastric lesions may possess cytoprotective effect.…”

Section: Discussionmentioning

confidence: 87%

“…It is widely used in ethnomedicine for the treatment of diverse diseases such as skin diseases, tumors, rheumatic pains, jaundice and dysentery [8]. The plant possesses oxytocic, antioxidant, antidiarrhoeal, antimicrobial, analgesic, anti-inflammatory and antipyretic properties [9][10][11][12]. The aim of the present study is to evaluate the activity of ethanolic leaf extract of B. coccineus on gastric mucosal damage by using models of different types of ulcers.…”

Section: Introductionmentioning

confidence: 99%

See 1 more Smart Citation

Ulcer protective effect of Byrsocarpus coccineus leaf extract in different experimental animal models

Christian¹,

Monday²,

Linus³

et al. 2015

J Coast Life Med

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Section: Discussionmentioning

confidence: 87%

Section: Introductionmentioning

confidence: 99%

Ulcer protective effect of Byrsocarpus coccineus leaf extract in different experimental animal models

Christian¹,

Monday²,

Linus³

et al. 2015

J Coast Life Med

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“…All V. paradoxa extracts exhibited bacteriostatic effects (Table 5) on all tested clinical isolates, but showed different minimum inhibitory concentration (MIC) which was also different with respect to each organism tested in the experiment. The bacteriostatic effect of these plant parts could possibly be due to the presence of saponins, which demonstrate remarkable physiological activity and forms lather, responsible for wound and skin protection (Ahmadu et al, 2006). Specifically, saponins have been suggested to exhibit greater antimicrobial effect and could serve as a precursor of steroidal substances with a wide range of physiological activities.…”

Section: Effect Of Ethanolic Extracts Of V Paradoxa Parts Against Sementioning

confidence: 99%

Comparative Antibacterial Efficacy of <i>Vitellaria paradoxa</i> (Shea Butter Tree) Extracts Against Some Clinical Bacterial Isolates

Ajijolakewu

AWARUN

2015

Not Sci Biol

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The antibacterial activities of the ethanolic extracts of seed, leaf and stem bark of Vitellaria paradoxa were investigated. The extracts were tested against three clinical bacterial pathogens, Staphylococcus aureus, Escherichia coli and Klebsiella pneumoniae using the agar diffusion and the broth dilution techniques. Ethanolic extracts of the plant parts showed activity against all the bacterial pathogens tested. At the highest extract concentration (200 mg/ml), the leaf extract exhibited the highest antimicrobial activity, while no activity was detected at the lowest concentration (3.13 mg/ml) against the tested isolates. Escherichia coli and Staphylococcus aureus were more susceptible to all extracts of V. paradoxa, while Klebsiella pneumoniae showed the least sensitivity. The efficacy of ethanolic extracts of Vitellaria paradoxa was compared to a commercial antibiotic streptomycin. There were differences in the minimum inhibitory concentration (MIC) of all the Vitellaria paradoxa ethanolic extracts with respect to the type of organism. All extracts exhibited bacteriostatic effects against the tested organisms at the experimented concentrations. Qualitative phytochemical screening of the extracts revealed the presence of saponins, tannins and alkaloids as the active principles of Vitellaria paradoxa's antimicrobial activity. V. paradoxa could be used as a potential source of antibiotic substance for a drug development.

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“…Byrsocarpus coccineus is an indigenous tropical plant found in West Africa (Kossivi et al, 2014). Previous studies have reported considerable antimicrobial activities of the extracts of B. coccineus on C. albicans, Escherichia coli, Salmonella typhi and Staphylococcus aureus (Ahmadu et al, 2006). The antimicrobial property of B. coccineus has been reported to be due to a coumaryl derivative and flavonoid glycoside isolated from its leaves (Akindele and Adeyemi, 2006).…”

Section: Introductionmentioning

confidence: 99%

“…The antimicrobial property of B. coccineus has been reported to be due to a coumaryl derivative and flavonoid glycoside isolated from its leaves (Akindele and Adeyemi, 2006). Other phytochemical constituents like tannins, sugar and saponins have been reported to contribute to its antimicrobial activity (Ahmadu et al, 2006). B. coccineus has also been used in the treatment of diarrhea (Akindele and Adeyemi, 2006).…”

Section: Introductionmentioning

confidence: 99%

Antifungal susceptibility pattern and identification of Candida species in women of child-bearing age suffering from malaria, typhoid and diabetes in Nsukka, Nigeria

Nwoko¹,

Mgbeahuruike²,

Ugwuijem³

et al. 2019

Afr. J. Microbiol. Res.

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Candidiasis in women of child-bearing age is a major problem in most hospitals in Nigeria. High vaginal swabs were analyzed for Candida presence in women of child bearing age using Chromogenic agar. Isolated Candida spp. were analyzed phylogenetically to trace their evolutionary relatedness. Growth rate assay was done using Sabouruand and Dextrose medium supplemented with NaCl and glucose. The resistance pattern of the Candida spp. was tested using fluconazole and extracts (methanol and ethyl) from Byrsocarpus coccineus. Out of the 79 fungal samples analyzed, 21 (26.6%) were C. tropicalis, 25 (31.6%) were C. krusei, 10 (12.7%) were C. parapsilosis and 8 (10.1%) were C. albicans. About 15 (19.0%) had mixed morphology on CHROM agar Candida and could not be identified. The healthy women presented very low percentage (8.9%) of Candida species. The sequenced Candida spp. had 100% sequence identity to C. tropicalis. High concentration of glucose (1 g/ml) and NaCl (0.5 M) decreased the growth of the fungus. In conclusion, C. tropicalis and C. krusei were more prevalent in the malaria patients. C. albicans were found mostly in the typhoid patients. The plant extracts showed lower antifungal activity in comparison with fluconazole but they showed a huge antifungal potential.

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Preliminary phytochemical and antimicrobial screening of the leaves of <i>Byrsocarpus coccineus</i> Schum & Thonn (Connaraceae)

Cited by 14 publications

References 7 publications

Ulcer protective effect of Byrsocarpus coccineus leaf extract in different experimental animal models

Ulcer protective effect of Byrsocarpus coccineus leaf extract in different experimental animal models

Comparative Antibacterial Efficacy of <i>Vitellaria paradoxa</i> (Shea Butter Tree) Extracts Against Some Clinical Bacterial Isolates

Antifungal susceptibility pattern and identification of Candida species in women of child-bearing age suffering from malaria, typhoid and diabetes in Nsukka, Nigeria

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