Preliminary pharmacokinetic studies of propylthiouracil in humans

Correlation between antithyroid effect and serum concentrations of propylthiouracil in patients with hyperthyroidism.

“…PTU is rapidly and almost completely absorbed after oral administration and cleared from the body with a terminal half-life in serum of about 1 h. No significant differences in these kinetic parameters were found between euthyroid and hyperthyroid subjects (Schuppan et al, 1973;Kampmann & Skovsted, 1975;McMurray et al, 1975).…”

“…The pharmacokinetics of propylthiouracil (PTU) in humans has recently been investigated in several studies (Schuppan et al, 1973;Kampmann & Skovsted, 1974;McMurray et al, 1975;Sitar & Hunninghake, 1975). PTU is rapidly and almost completely absorbed after oral administration and cleared from the body with a terminal half-life in serum of about 1 h. No significant differences in these kinetic parameters were found between euthyroid and hyperthyroid subjects (Schuppan et al, 1973;Kampmann & Skovsted, 1975;McMurray et al, 1975).…”

High-performance Liquid Chromatographic Determination of Plasma Propylthiouracil

“…After distribution equilibrium has been achieved, the plasma concentration declines exponentially, with a half-life commonly in the range of 60 rnin (3,(5)(6)(7)(8)(9)(10)(11), although other apparent elimination rates have been reported (1,4). First-order kinetics have been demonstrated over a wide range of doses (10).…”

“…Although the sensitivity of the other methods seems adequate to determine pharmacokinetics, the specificity of the total radioactivity method (1) and the colorimetric method (2) has been questioned (6,7). In particular, the lack of analytical specificity may have been responsible, in part, for some of the unusually prolonged half-lives reported (4).…”

High-pressure Liquid Chromatographic determination of Propylthiouracil in Human Plasma

“…A GLC method (5) was employed in two separate studies in humans (5,6). The major disadvantages of this procedure are the inherent problems associated with the formulation of derivatives by flash alkylation (7) and the necessity of elevating the column temperature after every two or three injections to remove slowly eluting compounds.…”