Preliminary Observations on Urinary Oestrogen Excretion in Certain Gynaecological Disorders

Brown, J. B.; Kellar, Robert J.; Matthew, G. Douglas

doi:10.1111/j.1471-0528.1959.tb01999.x

Cited by 129 publications

(19 citation statements)

References 6 publications

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“…in patient C.S. The values obtained are in the range normally encountered in post¬ menopausal subjects (see McBride, 1957;Brown, Kellar & Matthew, 1959). Neither Compound 22365 nor Compound 33828 affected the output of these hormones in any of the patients studied.…”

Section: Resultsmentioning

confidence: 76%

The Effect of Derivatives of Dithiocarbamoylhydrazine on Hormone Excretion in Postmenopausal Women

Bell¹,

Brown²,

Fotherby³

et al. 1962

Journal of Endocrinology

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Estimations of human pituitary gonadotrophins (HPG), total 17\ x=r eq-\ hydroxycorticosteroids, total 17-oxosteroids and oestrogens have been performed in seven hospitalized postmenopausal subjects receiving treatment with the dithiocarbamoylhydrazine derivatives Compound 22365 and Compound 33828 (Imperial Chemical Industries Ltd.).Both compounds were shown to be inhibitors of pituitary gonadotrophic function as indicated by urinary HPG assays; Compound 33828 was more active in this respect than Compound 22365. When Compound 22365 was administered to individual subjects at two different dose levels the time taken for urinary HPG levels to return to pretreatment values was longer in the case of the higher dose.Neither of the compounds studied produced any effect on adrenocortical function as judged by urinary assays of 17-hydroxycorticosteroids, 17\ x=r eq-\ oxosteroids and oestrogens.

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Section: Resultsmentioning

confidence: 76%

The Effect of Derivatives of Dithiocarbamoylhydrazine on Hormone Excretion in Postmenopausal Women

Bell¹,

Brown²,

Fotherby³

et al. 1962

Journal of Endocrinology

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“…This was expected, because abundant research has described increased circulating (37) and excreted (13,16,38,39) luteal estrogen levels in perimenopausal elongated cycles. Because of the disparity with PdG and the lack of an inverse relationship between luteal LH and E1G, the excess estrogens seem to have a source different from the corpus luteum.…”

Section: Discussionmentioning

confidence: 86%

“…Naturally elevated estrogen levels have been associated with thickening (46) and even cystic glandular hyperplasia of the endometrium (37,38). Given the characteristics of the elongated cycles, it is paramount to determine the real impact on health of this hormonal imbalance, particularly because nearly 47% of women experience at least 5 yr of menopausal transition (10).…”

Section: Discussionmentioning

confidence: 99%

Origins and Consequences of the Elongation of the Human Menstrual Cycle during the Menopausal Transition: The FREEDOM Study

Miró¹,

Parker²,

Aspinall³

et al. 2004

The Journal of Clinical Endocrinology & Metabolism

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The menopausal transition is characterized by the appearance of elongated cycles, which become longer and more frequent as menopause approaches. Several endocrine abnormalities have been attributed to these cycles; however, no quantitative studies of their causes and consequences exist to date. This study is based on sequential daily urinary concentrations of FSH, LH, estrone 3-glucuronide (E1G), and pregnanediol 3-glucuronide (PdG) from 34 women with perimenopausal menstrual irregularity (total of 289 cycles). The timing of ovarian response was determined as the day of E1G take-off (ETO). Other parameters measured were the mean FSH concentration before ETO (FSH(ETO)) and the midluteal levels of PdG, E1G, and LH. There was a strong parallelism between ETO and cycle length variability. FSH(ETO) levels increased gradually with ETO. Both ETO and FSH(ETO) were inversely related to luteal PdG and directly related to E1G. PdG and LH levels were inversely related. All comparisons were highly significant (P < 0.0001). We conclude that delayed ovarian response underlies the elongation of the menstrual cycle in the menopausal transition, which is likely to be caused by a temporary lack of ovarian responsiveness to FSH. A progressive decline in luteal PdG with increased E1G occurs in association with these trends.

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“…Median (range) lengths of cycle 1 in the ovulatory and anovulatory cycles according to STRAW group are shown in Table 3. Median (range) values of follicular phase length were 16 (11), 12.5 (10), 14 (9), and 16 (50) in the midreproductive age, late-reproductive age, early-menopausal transition, and late-menopausal transition groups, respectively, and median (range) values of luteal phase length were 14 (9), 13.5 (7), 14 (5), and 14 (4) days in the midreproductive age, late-reproductive age, early-menopausal transition, and late-menopausal transition groups, respectively. Ovulatory cycle length (cycle 1) was longer than 36 days in four women in the late-menopausal transition group (41, 49, 55, and 68 days long).…”

Section: Resultsmentioning

confidence: 98%

“…3 "Dysfunctional uterine bleeding" and endometrial hyperplasia are more common in the extremes of reproductive life, when irregular and anovulatory cycles are more prevalent. 4 A subjective increase in menstrual flow has been observed in cycles with high levels of estradiol (E2) during the follicular phase, [5][6][7] during the luteal phase, 3 at the onset of flow, 5,8 or when taken randomly throughout the menstrual cycle. 9 However, no studies have collected reproductive hormone data while quantitatively measuring menstrual blood loss to confirm or deny these early observations.…”

Section: Discussionmentioning

confidence: 99%

Quantitative Measurements of Menstrual Blood Loss in Ovulatory and Anovulatory Cycles in Middle- and Late-Reproductive Age and the Menopausal Transition

Hale¹,

Manconi²,

Luscombe³

et al. 2010

Obstetrics &Amp; Gynecology

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Preliminary Observations on Urinary Oestrogen Excretion in Certain Gynaecological Disorders

Cited by 129 publications

References 6 publications

The Effect of Derivatives of Dithiocarbamoylhydrazine on Hormone Excretion in Postmenopausal Women

The Effect of Derivatives of Dithiocarbamoylhydrazine on Hormone Excretion in Postmenopausal Women

Origins and Consequences of the Elongation of the Human Menstrual Cycle during the Menopausal Transition: The FREEDOM Study

Quantitative Measurements of Menstrual Blood Loss in Ovulatory and Anovulatory Cycles in Middle- and Late-Reproductive Age and the Menopausal Transition

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