Preliminary Observations on the Usefulness of a Decalcified, Freeze‐Dried Cancellous Bone Allograft Material in Periodontal Surgery

Pearson, G E; Rosen, S.; Deporter, Douglas

doi:10.1902/jop.1981.52.2.55

Cited by 57 publications

(26 citation statements)

References 15 publications

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“…In the past few decades the establishment of well regulated tissue banks has enabled dental surgeons to avoid the trauma of autograft retrieval by using allograft bone materials to fill a variety of jaw bone defects (Libin et al 1975;Marble 1968;Pearson et al 1981;Quintero et al 1982, Rummelhart et al 1989. Freeze Dried Bone Allograft (FDBA) (Burwell 1996;Carr and Hyatt 1955;Chalmas 1950;Francis et al 1995;Heiple et al 1963;Kreuz et al 1951;Lane et al 1972;Pappas and Beisaw 1968) and Demineralised Freeze Dried Bone Allograft (DFDBA) have been successfully used to generate bone (Francis et al 1995;Marble 1968;Pearson et al 1981;Quintero et al 1982;Rummelhart et al 1989;Urist 1965).…”

Section: Introductionmentioning

confidence: 99%

“…Freeze Dried Bone Allograft (FDBA) (Burwell 1996;Carr and Hyatt 1955;Chalmas 1950;Francis et al 1995;Heiple et al 1963;Kreuz et al 1951;Lane et al 1972;Pappas and Beisaw 1968) and Demineralised Freeze Dried Bone Allograft (DFDBA) have been successfully used to generate bone (Francis et al 1995;Marble 1968;Pearson et al 1981;Quintero et al 1982;Rummelhart et al 1989;Urist 1965).…”

Section: Introductionmentioning

confidence: 99%

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Evaluation of demineralised, freeze-dried, irradiated bone allografts in the treatment of osseous defects in the oral cavity

Gajiwala

Kumar

Chokhani

2006

Cell Tissue Banking

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Demineralised, freeze-dried bone allografts (DFDBA) have been used extensively by dentists in the treatment of periodontal and periapical osseous defects resulting from inflammatory diseases. Their use in India however, is limited by the availability of quality allografts and the high cost of imported alternatives. A study was conducted to assess the osteogenic potential of DFDBA prepared for the first time in India by the Tata Memorial Hospital (TMH) Tissue Bank. The DFDBA was used in the treatment of osseous defects after removal of periapical lesions associated with devitalised teeth in 10 healthy patients. At the 6-month recall visit all the patients showed a remarkable decrease in the grades of mobility, and 9 out of the 10 patients showed radiographic evidence of complete healing of the osseous defects with evidence of normal bony trabaeculae. These findings indicate that the indigenously prepared DFDBA is a cost effective, biocompatible material with osteogenic potential that can be used effectively in treating osseous defects of periapical lesions associated with non vital teeth.

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Section: Introductionmentioning

confidence: 99%

Section: Introductionmentioning

confidence: 99%

Evaluation of demineralised, freeze-dried, irradiated bone allografts in the treatment of osseous defects in the oral cavity

Gajiwala

Kumar

Chokhani

2006

Cell Tissue Banking

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“…Demin~ralized freeze-dried bovine bone xenograft (DFDBBX) was shown to be highly osteoconductive when compared to osseous coagulum, bone blend and freeze-dried bone (6). Clinical and histological studies in human indicated that DFDBBX significantly enhanced new attachment formation in submerged and non-submerged intrabony defects (7,8). Animal investigations had also shown evidence of new host bone deposition at 6 months following the placement of the bone xenograft (8).…”

Section: Introductionmentioning

confidence: 99%

The Use Demineralized Freeze-Dried Bovine Bone Xenograft In Reducing Post-Surgical Periodontal Pocket Depth

Baharuddin

Kamin

Samsuddin

2003

ADUM

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This study evaluated the effectiveness of demineralized freeze-dried bone xenograft in reducing post-surgical pocket depth in moderate to advanced adult periodontitis in patients. Nine patients with a total of eighteen intrabony defects were selected for this study. The bony defects were matched for tooth type, location and pocket depth. Following an initial non-surgical treatment, only pockets of 5 to 7 mm deep were indicated for surgery. Periodontal pockets were measured pre-operatively and at 3, 6 and 9 months post-surgically. The study protocol included a split mouth design, where surgical treatment was carried out at both test and control sites. The test sites were assigned demineralized freeze-dried bone xenograft and the control sites were subjected to debridement alone without the use of demineralized freeze-dried bone xenograft. The results from this study showed a statistically significant difference in the mean pocket depth at 6 and 9 months post-operatively for both test and control groups, but there was no statistically significant difference at 3 months. In conclusion, demineralized freeze-dried bone xenograft was ineffective in reducing periodontal pocket depth in patients with moderate to severe periodontitis, as compared to surgical debridement alone.

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“…DFDBA is an allogenic bone graft, that has been used extensively in periodontal therapy (Abolfazli et al 2008;Pearson et al 1981;Quintero et al 1982;Rummelhart et al 1989;Francis et al 1995;). In periodontal defects it results in significant probing depth reduction, attachment level gain and osseous regeneration (Trombelli et al 1989).…”

mentioning

confidence: 99%

“…The rationale for the use of DFDBA includes the fact that in addition to its osteoconductive property, osteoinductive proteins capable of inducing new bone i.e., bone morphogenic proteins, can be isolated from it (Pearson et al 1981;Quintero et al 1982;Urist 1965;Urist and Strates 1971). Histological evidence further demonstrates that DFDBA grafts support the formation of a new attachment apparatus in intrabony defects, (Bowers et al 1989;Reynold et al 2003).…”

mentioning

confidence: 99%

Comparative study of indigenously prepared and imported, demineralized, freeze-dried, irradiated bone allograft in the treatment of periodontal infrabony defects

et al. 2014

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Demineralized freeze-dried bone allograft (DFDBA) has been used extensively in periodontal therapy. Questions have been raised however, about the osteogenic potential of the variety of grafts available. In India the cost factor is another important consideration. The aim of this study therefore was to evaluate the clinical efficiency of the low priced, indigenously prepared DFDBA obtained from the Tata Memorial Hospital (TMH) Tissue Bank, in periodontal regeneration in infrabony periodontal defects, as compared to DFDBA obtained from the Pacific Coast Tissue Bank (DEMBONE). The latter was used as the control. 16 patients with bilaterally similar periodontal infrabony defects were selected, and randomly allotted to the test and control groups. At baseline, using standardized protocol, recession, probing depths (PD), and clinical attachment levels (CAL) were measured, following which periodontal surgery was carried out, with placement of the respective graft materials. Patients were recalled after 6 months for re-assessment. Statistically significant improvement was obtained for PD reduction and CAL gain for both groups (p < 0.05). However, no significant difference was observed between the test and control groups. It was therefore concluded that both the materials from different tissue banks are equally effective clinically, with the test material being additionally cost effective.

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Preliminary Observations on the Usefulness of a Decalcified, Freeze‐Dried Cancellous Bone Allograft Material in Periodontal Surgery

Cited by 57 publications

References 15 publications

Evaluation of demineralised, freeze-dried, irradiated bone allografts in the treatment of osseous defects in the oral cavity

Evaluation of demineralised, freeze-dried, irradiated bone allografts in the treatment of osseous defects in the oral cavity

The Use Demineralized Freeze-Dried Bovine Bone Xenograft In Reducing Post-Surgical Periodontal Pocket Depth

Comparative study of indigenously prepared and imported, demineralized, freeze-dried, irradiated bone allograft in the treatment of periodontal infrabony defects

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