Preliminary observations on perfluorinated compounds in plasma samples (1977–2004) of young German adults from an area with perfluorooctanoate-contaminated drinking water

Wilhelm, Michael; Hölzer, Jürgen; Dobler, Lorenz; Rauchfuss, Knut; Midasch, O; Kraft, Martin; Angerer, Jürgen; Wiesmüller, Gerhard Andreas

doi:10.1016/j.ijheh.2008.04.008

Cited by 59 publications

(48 citation statements)

References 12 publications

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“…6). No significant temporal trends for PFOS were observed in only 6 datasets of human samples [89,102,115,121,143], and two datasets of dietary items [99,142], but in each case the power to detect a trend was low. Overall, the declining trends for PFOS generally coincide with the timing of the 3M Co. phase out by 2002.…”

Section: Pfos Change Point Analysismentioning

confidence: 91%

“…In male and female serum from Arnsberg, Germany, a continuous significant increase was detected between 1977 and 2004 [143], but few samples were available from after the 3M Co phase-out. One slightly longer dataset from Norway (1979-2007) also showed a significant increasing trend for the whole period, but concentrations in 2001 (2.0 ng/ mL) were very similar to 2007 (1.9 ng/mL), suggesting a levelling-off.…”

Section: Pfhxsmentioning

confidence: 99%

See 1 more Smart Citation

What is the effect of phasing out long-chain per- and polyfluoroalkyl substances on the concentrations of perfluoroalkyl acids and their precursors in the environment? A systematic review

Land¹,

Wit²,

Bignert³

et al. 2018

Environ Evid

162

122

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Background: There is a concern that continued emissions of man-made per-and polyfluoroalkyl substances (PFASs) may cause environmental and human health effects. Now widespread in human populations and in the environment, several PFASs are also present in remote regions of the world, but the environmental transport and fate of PFASs are not well understood. Phasing out the manufacture of some types of PFASs started in 2000 and further regulatory and voluntary actions have followed. The objective of this review is to understand the effects of these actions on global scale PFAS concentrations.Methods: Searches for primary research studies reporting on temporal variations of PFAS concentrations were performed in bibliographic databases, on the internet, through stakeholder contacts and in review bibliographies. No time, document type, language or geographical constraints were applied in the searches. Relevant subjects included human and environmental samples. Two authors screened all retrieved articles. Dual screening of 10% of the articles was performed at title/abstract and full-text levels by all authors. Kappa tests were used to test consistency. Relevant articles were critically appraised by four reviewers, with double checking of 20% of the articles by a second reviewer. Meta-analysis of included temporal trends was considered but judged to not be appropriate. The trends were therefore discussed in a narrative synthesis.

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Section: Pfos Change Point Analysismentioning

confidence: 91%

Section: Pfhxsmentioning

confidence: 99%

What is the effect of phasing out long-chain per- and polyfluoroalkyl substances on the concentrations of perfluoroalkyl acids and their precursors in the environment? A systematic review

Land¹,

Wit²,

Bignert³

et al. 2018

Environ Evid

162

122

View full text Add to dashboard Cite

show abstract

“…In contrast, PFHxS levels steadily increased since 1977. [38] A comprehensive study was carried out in Norway, covering a time period of , 30 years (1976-2007). [39] [30,32] and Calafat et al [33,34] and estimated total global POSF production volumes, adapted from Paul et al [1] Temporal trends of PFOS, PFOA and PFHxS in blood of New York State infants representing 2640 one to two-day-old infants (arithmetic means; data modified from Spliethoff et al [36] ; whole blood data multiplied by a factor of 2).…”

Section: Levels and Trends In Humansmentioning

confidence: 99%

Trends of polyfluoroalkyl compounds in marine biota and in humans

Sturm

Ahrens

2010

Environ. Chem.

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Environmental context. Polyfluoroalkyl compounds are used in a variety of industrial and consumer applications, including polymer production and for surface treatment of textiles and paper. Research over the last 10 years has shown that these compounds are ubiquitous environmental contaminants -they are extremely persistent, show toxic effects and accumulate in the food chain. We evaluate global, temporal and spatial trends of these important emerging contaminants.Abstract. This review gives an overview of existing knowledge of polyfluoroalkyl compounds (PFCs) in humans and in marine biota. Temporal trends and spatial distribution of PFCs were globally compared in humans, marine mammals, seabirds and fish. In general, PFC concentrations in the environment have increased significantly from the beginning of the production up to the 1990s. After the phase-out of perfluorooctane sulfonyl fluoride (POSF) production starting in 2000, PFC concentrations in humans generally decreased. In marine biota no clear temporal trends were observed. The temporal trends depended on the species, their trophic levels and the geographical locations. PFC patterns in humans and in marine wildlife species were compared regarding perfluorooctane sulfonate (PFOS), perfluorooctanoate (PFOA), their shorter and longer chain homologues (C 4 -C 15 ) and precursor compounds. Finally knowledge gaps were identified and recommendations for future work were presented.

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“…[89][90][91] In some cases, water treatment using activated carbon has been shown to be effective for removing longer chain PFAs such as n-PFOA from contaminated source waters. [20,[54][55][56]70] PFAs, like their hydrocarbon fatty acid analogs, [92,93] also sorb to inorganic surfaces such as sands, clays, iron oxides, calcium fluoride, and surface modified silicas. [82,94,95] but organic matter sorption is thought to be dominant in most environmental systems and offer the most promising for treatment methods.…”

Section: Introductionmentioning

confidence: 99%

Congener specific organic carbon normalized soil and sediment-water partitioning coefficients for the C1 through C8 perfluoroalkyl carboxylic and sulfonic acids

Rayne

Forest

2009

Nature Precedings

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Organic carbon normalized soil and sediment-water partitioning (K oc ) coefficients were estimated for all C 1 through C 8 perfluorinated alkylsulfonic acid (PFSA) and alkylcarboxylic acids (PFCA) congeners. The limited experimental K oc dataset for the straight chain C 7 through C 10 PFCAs and C 8 and increasing perfluoroalkyl chain length and linearity increase K oc values with substantial intra-and interhomologue variation and interhomologue mixing. Variability in K oc values among the PFCA and PFSA congeners will likely lead to an enrichment of more linear and longer chain isomers in organic matter fractions, resulting in aqueous phases fractionated towards shorter chain branched congeners. The expected magnitude of fractionation will require inclusion in source apportionment models and risk assessments. A comparison of representative established quantitative structure property relationships for estimated K oc values from octanol-water partitioning constants suggests that equilibrium partitioning frameworks may be applicable towards modeling PFCA and PFSA environmental fate processes and warrants further study using other partitioning coefficients for which suitable experimental data is available.

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Preliminary observations on perfluorinated compounds in plasma samples (1977–2004) of young German adults from an area with perfluorooctanoate-contaminated drinking water

Cited by 59 publications

References 12 publications

What is the effect of phasing out long-chain per- and polyfluoroalkyl substances on the concentrations of perfluoroalkyl acids and their precursors in the environment? A systematic review

What is the effect of phasing out long-chain per- and polyfluoroalkyl substances on the concentrations of perfluoroalkyl acids and their precursors in the environment? A systematic review

Trends of polyfluoroalkyl compounds in marine biota and in humans

Congener specific organic carbon normalized soil and sediment-water partitioning coefficients for the C1 through C8 perfluoroalkyl carboxylic and sulfonic acids

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