Preliminary observations of Holmium:YAG laser tissue interaction using human uterus

Duffy, Sean; Davis, Mike; Sharp, F.; Stamp, J. M.; Ginsberg, Robert J.

doi:10.1002/lsm.1900120206

Cited by 12 publications

(6 citation statements)

References 9 publications

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“…Haase, et al 87 found a comparable zone of necrosis extending 100 to 1000 μm beyond the crater edge when this laser was used to ablate atherosclerotic plaques in arterial specimens. A somewhat larger zone of necrosis extending 800 to 1800 μm beyond the crater edge was noted by Duffy, et al 99 when the holmium:YAG laser was used to ablate tissue of the human uterus.…”

Section: Discussionmentioning

confidence: 78%

“…Studies have demonstrated the ability of this laser to break apart gallstones 96,97 and to remove deposits from heart valves 98 . Experiments have also been conducted to determine the efficacy of the holmium:YAG laser in gynecologic, 99 gastrointestinal, 100‐103 vascular, 104 and dental 105 surgical procedures.…”

Section: Use Of Lasers For Rhinologic Surgerymentioning

confidence: 99%

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Holmium

Metson

1996

The Laryngoscope

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Although surgical lasers were introduced to the field of otolaryngology more than 20 years ago, their use in rhinologic surgery has remained relatively limited. With the development of the holmium:yttrium-aluminum-garnet (YAG) laser, a device is now available that offers those features necessary for effective sinus surgery:precise bone ablation, efficient soft tissue coagulation, and fiberoptic transmission. This solid-state laser of 2.1-microns wavelength can be coupled with endoscopic instrumentation for the surgical treatment of sinus disease. This study was conducted to determine the clinical efficacy of the holmium:YAG laser for endoscopic sinus surgery. A microscopic analysis of laser-treated sinus tissue was also performed in an attempt to determine the histologic basis of the observed clinical findings. In a prospective, randomized, controlled, single-blinded study, 32 consecutive patients underwent endoscopic sinus surgery using the holmium:YAG laser on one side of the nose and conventional endoscopic instrumentation on the other side. Patients rated symptoms for each side of the nose at 1 week, 1 month, 3 months, 6 months, and 2 years after surgery. Healing parameters were similarly rated by the surgeon. Until the study was completed, patients were not told which side of the nose had been treated with laser surgery. No intraoperative complications occurred. The mean intraoperative blood loss was 24.6 mL less on the laser-treated side of the nose than on conventionally treated side (P < .001). At 1 week after surgery, there was increased mucosal edema on the laser-treated side (P < .01). Crust formation was greater on the conventionally treated side at 1 week and was greater on the laser-treated side at 1 mouth (P < .01). Improvements in symptoms of pain, congestion, and drainage were equivalent for both treatment modalities (P < .001). Microscopic analysis demonstrated the ability of the holmium:YAG laser to remove tissue in relatively thin layers with ablation depths of 260 +/- 8.2 microns, 286 +/- 9.4 microns, and 341 +/- 20.4 microns per pulse at energy levels of 0.5, 1.0, and 1.5 J, respectively. A zone of thermal necrosis extending up to 1 mm beyond the site of laser impact was thought to correlate with the increased postoperative edema observed on the laser-treated side. Endoscopic sinus surgery with the holmium:YAG laser is as effective as nonlaser techniques in relieving the symptoms of chronic sinusitis. Laser surgery offers improved intraoperative hemostasis, but it causes increased postoperative tissue edema. The holmium:YAG laser provides the surgeon with an additional tool for the performance of safe, effective sinus surgery.

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Section: Discussionmentioning

confidence: 78%

Section: Use Of Lasers For Rhinologic Surgerymentioning

confidence: 99%

Holmium

Metson

1996

The Laryngoscope

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“…In addition, high-speed photographs of the ablation process have revealed that explosive removal of tissue occurs [25,26]. Tissue interaction studies on nonskeletal tissues using laser systems operating in the midinfrared have shown that the extent of thermal tissue damage varies according to the type of tissue [11,18] and increases with higher repetition rates.…”

Section: Discussionmentioning

confidence: 98%

“…Previous experimental studies on test cuts in different tissues in vitro and in vivo have shown that 2,940 nm and 2,120 nm radiation can effectively cut a variety of tissues, especially bone, leaving between 5 and 600 m of damage [8][9][10][11]. The presence of plasma illumination during hardand soft-tissue processing with high fluences suggests that thermal ionization or photoablation occurs.…”

Section: Introductionmentioning

confidence: 96%

Soft-tissue effects of the holmium:YAG laser: An ultrastructural study on oral mucosa

et al. 1997

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“…This property of the Ho:YAG laser has proven to be useful in other specialties in addition to thoracic surgery, such as urology [10,11], orthopedics [12,13], general gastroenterological surgery [14,15], otorhinology [16], and gynecology [17]. In the future, more noninvasive surgery will be possible with the Ho:YAG laser in conjunction with the development of various new biocompatible repair materials.…”

Section: Discussionmentioning

confidence: 99%

Treating bullous lung disease with holmium YAG laser in conjunction with fibrin glue and DEXON™ mesh

et al. 1998

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Background and Objective Holmium YAG (Ho:YAG) laser energy is highly absorbed by water, and this property is useful to uniformly ablate pulmonary bullae. The current study summarizes the data of a 39‐month follow‐up of patients treated for bullae with a Ho:YAG laser. Study Design/Materials and Methods: We used a Ho:YAG laser from August 1994 to April 1997 to treat small pulmonary bullae in 50 patients. For the first five patients, Ho:YAG laser ablation was followed by resection for histological assessment. In the next six patients, fibrin glue was applied following bullae ablation with the Ho:YAG laser. In all subsequent patients, a DEXON™ (polyglycolic acid) mesh patch soaked in fibrin glue was employed after ablation. Results From the six patients receiving only the fibrin glue following laser ablation, delayed pneumothorax developed in one patient. In the subsequent 39 patients patched with DEXON™ mesh soaked in fibrin glue, none encountered delayed pneumothorax. Conclusion The combined use of fibrin glue and Dexon™ mesh with the Ho:YAG laser may be an effective technique for treating bullous lung disease. Lasers Surg. Med. 22:219–222, 1998. © 1998 Wiley‐Liss, Inc.

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Preliminary observations of Holmium:YAG laser tissue interaction using human uterus

Cited by 12 publications

References 9 publications

Holmium

Holmium

Soft-tissue effects of the holmium:YAG laser: An ultrastructural study on oral mucosa

Treating bullous lung disease with holmium YAG laser in conjunction with fibrin glue and DEXON™ mesh

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