Preliminary Observations of a Novel Topical Oil with Analgesic Properties for Treatment of Acute and Chronic Pain Syndromes

Pergolizzi, Joseph V.; Pappagallo, M.; Raffa, Robert B.; Gharibo, Chris; Phillips, Reed B.; Desjonquères, Stéphane; Tabor, Aaron

doi:10.1111/j.1533-2500.2009.00350.x

Cited by 10 publications

(10 citation statements)

References 34 publications

Supporting

Mentioning

Contrasting

Order By: Relevance

“…The use of topical “essential oxygen oil” was reviewed in a 2010 paper [127]. This essential oil is a hyperoxygenated, peroxidized, triglycerol-oxyester-rich oil.…”

Section: Other Drug Options and Combinationsmentioning

confidence: 99%

Skin Matters: A Review of Topical Treatments for Chronic Pain. Part Two: Treatments and Applications

et al. 2015

Self Cite

View full text Add to dashboard Cite

In Part One of this two-part series, we discussed skin physiology and anatomy as well as generalities concerning topical analgesics. This modality of therapy has lesser side effects and drug–drug interactions, and patients tolerate this form of therapy better than many oral options. Unfortunately, this modality is not used as often as it could be in chronic pain states, such as that from neuropathic pain. Part Two discusses specific therapies, local anesthetics, and other drugs, as well as how a clinician might use specific aspects of a patient’s neuropathic pain presentation to help guide them in the selection of a topical agent.

show abstract

“…The use of topical “essential oxygen oil” was reviewed in a 2010 paper [127]. This essential oil is a hyperoxygenated, peroxidized, triglycerol-oxyester-rich oil.…”

Section: Other Drug Options and Combinationsmentioning

confidence: 99%

Skin Matters: A Review of Topical Treatments for Chronic Pain. Part Two: Treatments and Applications

et al. 2015

Self Cite

View full text Add to dashboard Cite

show abstract

“…Some examples are the 5% lidocaine medicated plaster, 56 the NSAIDs patches, such as the diclofenac epolamine patch, 57 menthol, 58 and essential oxygen oil. 59,60 The advantages of topical products include localized delivery of medication, good evidence for efficacy, better tolerability due to less or no systemic action, and possible benefits in terms of patient adherence. 61 The capsaicin patch, containing an 8% concentration of capsaicin, 62 acts locally but not as an analgesic: a 30-60-minute application provides an improvement for several weeks/months by local nerve defunctionalization.…”

Section: Topical Analgesicsmentioning

confidence: 99%

Fixed-dose combinations at the front line of multimodal pain management: perspective of the nurse-prescriber

O'Brien¹,

Pergolizzi²,

Laar³

et al. 2013

NRR

Self Cite

View full text Add to dashboard Cite

Pain should be treated promptly and effectively to restore the patient to full function, avoid pain chronification, and preserve quality of life. A recent pain specialists' meeting discussed the use of different pharmacological treatment options, such as topical analgesics, nonopioid agents (such as paracetamol and nonsteroidal anti-inflammatory drugs), weak and strong opioids, and fixed-dose combination products in the management of moderate to severe pain from different etiologies. One of the topics discussed in, and subsequent to, this meeting was the role of fixed-dose combination products for nurse-prescribers who are in many ways at the front line of managing both acute and chronic pain syndromes. The panel agreed that proper product selection should take into account the patient's age, condition, type of pain, and comorbidities, as well as balance safety with effectiveness. Although nurse-prescribers need to be aware of cumulative paracetamol dosing, fixed-dose combination products, such as tramadol-paracetamol, may offer important advantages, eg, by providing opioid-sparing without sacrificing efficacy.

show abstract

“…Peroxide oil, also known as essential oxygen oil (7), is a topical medication made from naturally occurring ingredients, as reviewed below. It possesses analgesic as well as anti‐inflammatory properties.…”

Section: Introductionmentioning

confidence: 99%

“…It is commercially available over‐the‐counter (OTC) in Europe and now also in the United States. Unlike many such products, it has been the subject of several clinical studies [reviewed in (7)]. Based on the clinical studies, peroxide oil demonstrates analgesic effects against a variety of acute and chronic pains and improves skin oxygen content and other dermatological parameters.…”

Section: Introductionmentioning

confidence: 99%

Deciphering the mechanism(s) of action of natural products: analgesic peroxide oil as example

Raffa

Pergolizzi

2010

Journal of Clinical Pharmacy and Therapeutics

View full text Add to dashboard Cite

Summary Background: There are multiple reports of natural products having therapeutic effect. In an era of evidence‐based medicine, clinical trials inform clinical decisions regarding use of the product, but prevailing preference is to identify and use a single ‘active ingredient’. Yet, the clinical benefit of a natural product might derive from the fortuitous combination of its multiple components. Therefore, the elucidation of the mechanism(s) of action of natural products is important, but presents significant challenges. This article examines this issue using peroxide oil (essential oxygen oil) as an illustrative example. Objective: To review the published literature of a natural product in an effort to elucidate postulated mechanism(s) of action of a complex mixture. Methods: The clinical and preclinical literature was reviewed from the perspective of its contribution to elucidating a mechanism of analgesic action of a natural product. Results: Peroxide oil contains ingredients that are associated with analgesic mechanisms, such inhibition of lipid peroxidation and arachidonic acid metabolism and non‐opioid, glibenclamide‐sensitive receptor‐mediated and KATP–NO–cGMP channel pathways. Conclusion: Although its exact mechanism remains unknown, peroxide oil provides an example of how a natural product can be evaluated for plausible mechanistic explanation of its purported therapeutic efficacy. Such an approach seems valuable, since, as in this case, the constituents appear to contribute in an additive or synergistic manner, something not possible with a single substance.

show abstract

Preliminary Observations of a Novel Topical Oil with Analgesic Properties for Treatment of Acute and Chronic Pain Syndromes

Abstract: Based on studies completed, essential oxygen oil has shown itself to be safe, has demonstrated positive analgesic effects for the treatment of acute and chronic pain, and has improved oxygen content in the skin as well as other dermatological parameters.

Cited by 10 publications

References 34 publications

Skin Matters: A Review of Topical Treatments for Chronic Pain. Part Two: Treatments and Applications

Skin Matters: A Review of Topical Treatments for Chronic Pain. Part Two: Treatments and Applications

Fixed-dose combinations at the front line of multimodal pain management: perspective of the nurse-prescriber

Deciphering the mechanism(s) of action of natural products: analgesic peroxide oil as example

Contact Info

Product

Resources

About