Preliminary Observation on Pancreatic Duct Adenocarcinoma Induced by Intraductal Administration of N‐ethyl‐n′ ‐nitro‐n‐nitrosoguanidine in Dogs

Kamano, Toshiki; Azuma, Noboru; Katami, Atsuo; Tamura, J; Sakakibara, Noburu; Matsumoto, Michio; Mizumoto, Kazuhiro; Kitazawa, Shunji; Konishi, Yoichi

doi:10.1111/j.1349-7006.1988.tb00001.x

Cited by 11 publications

(5 citation statements)

References 6 publications

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“…Because of the loss of exocrine pancreatic tissue both branches of the accessory pancreatic duct ran parallel to the duodenum. ERP might reveal duct changes in dogs with spontaneous chronic pancreatic diseases similar to those reported in dogs with experimentally induced chronic pancreatitis or pancreatic carcinoma 41–43 …”

Section: Discussionmentioning

confidence: 67%

“…ERP might reveal duct changes in dogs with spontaneous chronic pancreatic diseases similar to those reported in dogs with experimentally induced chronic pancreatitis or pancreatic carcinoma. [41][42][43] In conclusion, endoscopic retrograde cholangio-pancreatography is a promising imaging technique that can be performed safely in dogs. Results of endoscopic retrograde cholangiography were already used successfully in the diagnosis and management of two dogs with enlarged common bile duct and intraductal filling defects.…”

Section: Discussionmentioning

confidence: 99%

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Endoscopic Retrograde Cholangio‐pancreatography in Dogs With Chronic Gastrointestinal Problems

Spillmann

Schnell-Kretschmer

Dick

et al. 2005

Vet Radiology Ultrasound

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Endoscopic retrograde cholangio-pancreatography is a combination of endoscopy and fluoroscopy used for radiographic imaging of the biliary and pancreatic ducts. In order to assess its feasibility and to describe abnormal findings in dogs, this technique was performed in 30 dogs with nonspecific chronic gastrointestinal disturbances. Using an 11-mm side-view endoscope, retrograde cholangiography was successful in 20/30 dogs (67%) and pancreatography in 21/30 (70%). Success was affected by intraduodenal food, mucus or blood, problems in papillary cannulation, stomach overdistention, body size, and changes in duodenal mucosa. It was impossible to perform the procedure in dogs weighing < 10 kg with the available material. Endoscopic retrograde cholangiography revealed findings that differed from previous reports in healthy beagles in 5/20 dogs. Findings included enlarged common bile duct (n = 2), intraductal filling defects (n = 2), and deviated course of common bile duct (n = 1), and major papilla stenosis (n = 1). In the dog with major papilla stenosis and intraductal filling defects, endoscopic guided sphincterotomy was performed. Endoscopic retrograde pancreatography revealed an abnormal course of the accessory pancreatic duct in 2/21 dogs. In both dogs with proven end-stage pancreatic acinar atrophy, the left duct branch did not run distal the stomach to the left but went parallel to the right duct branch and the duodenum. Repeated clinical and laboratory examinations revealed no signs of complications after endoscopic retrograde cholangio-pancreatography. It was concluded that this imaging technique is promising for the diagnosis of biliary and pancreatic diseases in dogs. It also offers the chance for new treatment options such as endoscopic guided sphincterotomy in dogs.

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Section: Discussionmentioning

confidence: 67%

Section: Discussionmentioning

confidence: 99%

Endoscopic Retrograde Cholangio‐pancreatography in Dogs With Chronic Gastrointestinal Problems

Spillmann

Schnell-Kretschmer

Dick

et al. 2005

Vet Radiology Ultrasound

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“…It is also imperative to consider facets of tumor biology beyond the nociceptive system (i.e., tumor growth, immune response) in pharmacological studies related to cancer pain; novel cancer pain therapies should not exacerbate cancer progression and interpretation of analgesia should be considered along with tumor size. Lastly, reverse translation could also be improved through the inclusion of large animal models [i.e., porcine ( Robertson et al, 2020 ), canine ( Kamano et al, 1988 )]. There have been significant advances in veterinary oncology as well as validation of pain scales for companion animals ( Brown et al, 2015 ; Lascelles et al, 2019 ) which provides an opportunity to study spontaneous cancer pain in larger species ( Brown et al, 2015 ; Brown, 2016 ; Monteiro et al, 2018 ).…”

Section: Considerations For Reverse Translationmentioning

confidence: 99%

Animal Models of Cancer-Related Pain: Current Perspectives in Translation

2020

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The incidence of pain in cancer patients during diagnosis and treatment is exceedingly high. Although advances in cancer detection and therapy have improved patient prognosis, cancer and its treatment-associated pain have gained clinical prominence. The biological mechanisms involved in cancer-related pain are multifactorial; different processes for pain may be responsible depending on the type and anatomic location of cancer. Animal models of cancer-related pain have provided mechanistic insights into the development and process of pain under a dynamic molecular environment. However, while cancer-evoked nociceptive responses in animals reflect some of the patients’ symptoms, the current models have failed to address the complexity of interactions within the natural disease state. Although there has been a recent convergence of the investigation of carcinogenesis and pain neurobiology, identification of new targets for novel therapies to treat cancer-related pain requires standardization of methodologies within the cancer pain field as well as across disciplines. Limited success of translation from preclinical studies to the clinic may be due to our poor understanding of the crosstalk between cancer cells and their microenvironment (e.g., sensory neurons, infiltrating immune cells, stromal cells etc.). This relatively new line of inquiry also highlights the broader limitations in translatability and interpretation of basic cancer pain research. The goal of this review is to summarize recent findings in cancer pain based on preclinical animal models, discuss the translational benefit of these discoveries, and propose considerations for future translational models of cancer pain.

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“…Epithelial hyperplasia was further produced in canine models by the perfusion of the main pancreatic duct with deoxycholate [82]. Kamano et al [83,84] and Sato [85] were able to produce ductal adenocarcinomas with N-ethyl-N)-nitrosoguanidine in a few dogs. Although the capability of the canine pancreas to metabolize BOP was shown, neither systemic nor local application of this compound could induce pancreatic carcinomas in dogs [85,86].…”

Section: Other Modelsmentioning

confidence: 99%

Experimental Animal Models in Pancreatic Carcinogenesis: Lessons for Human Pancreatic Cancer

Standop

Schneider

Ulrich

et al. 2001

Dig Dis

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The silent course of pancreatic cancer and its explosive fatal outcome have hindered studies of tumor histogenesis and the identification of early biochemical and genetic alterations that could help to diagnose the disease at a curable stage and develop therapeutic strategies. Experimental animal models provide important tools to assess risk factors, as well as preventive and therapeutic possibilities. Although several pancreatic cancer models presently exist, only models that closely resemble human tumors in morphological, clinical, and biological aspects present useful media for preclinical studies. Because an estimated 70% of human tumors are induced by carcinogens and because a significant association has been found between cigarette smoking and pancreatic cancer, chemically induced models are of particular value. Moreover, in such models the etiology, modifying factors, effects of diets, and naturally occurring products can be studied and early diagnostic, preventive, and therapeutic possibilities sought out. Many of the existing models are described in this review, and the advantages and shortcomings of each model and their clinical implications are discussed.

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Preliminary Observation on Pancreatic Duct Adenocarcinoma Induced by Intraductal Administration of N‐ethyl‐n′ ‐nitro‐n‐nitrosoguanidine in Dogs

Cited by 11 publications

References 6 publications

Endoscopic Retrograde Cholangio‐pancreatography in Dogs With Chronic Gastrointestinal Problems

Endoscopic Retrograde Cholangio‐pancreatography in Dogs With Chronic Gastrointestinal Problems

Animal Models of Cancer-Related Pain: Current Perspectives in Translation

Experimental Animal Models in Pancreatic Carcinogenesis: Lessons for Human Pancreatic Cancer

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