“…(Burns et al, 1957;Stephen et al, 1957;Robson and Sheridan, 1957;Brindle et al, 1957 ;Virtue et al, 1958 ;Little et al, 1958;Carson et al, 1959 ;Visser and Tarrow, 1959 ;Bianchetti et al, 1960). With this background it therefore came as something of a surprise when the reports of serious and often fatal hepatic complications appeared.…”