Preliminary Investigation on Degradation Behavior and Cytocompatibility of Ca-P-Sr Coated Pure Zinc

Abstract

Zinc and its alloys show a good application prospect as a new biodegradable material. However, one of the drawbacks is that Zn and its alloys would induce the release of more Zn ions, which are reported to be cytotoxic to cells. In this study, a Ca-P-Sr bioactive coating was prepared on the surface of pure zinc by the hydrothermal method to address this issue. The morphology, thickness, and composition were characterized, and the effects of the coating on the degradation, cell viability, and ALP staining were investigated. The results demonstrated that the degradation rate of pure zinc was reduced, while the cytocompatibility was significantly improved after pure zinc was treated with Ca-P-Sr coating. It is considered that the Ca-P-Sr bioactive coating prepared by the hydrothermal method has promising application in the clinic.

Creation of Bioactive Ceramic Composite Coatings on Zn–Mn–Mg Alloy via Micro-arc Oxidation and Hydrothermal Treatment for Orthopedic Implant Applications

“…Du et al 36 quickly formed hydroxyapatite crystal surface with high biological activity on a titanium dioxide micro-arc oxidation coating by the microwave hydrothermal method. Ke et al 37 prepared the dense Ca−P−Sr bioactive coating on the surface of pure Zn by the hydrothermal method, which regulated the corrosion rate of pure zinc, significantly promoted the proliferation of cells, and showed good cytocompatibility. Li et al 38 obtained Ca−P coated Zn−Mg alloys by water bath treatment with Zn−P coating as the middle layer.…”

Advances in Measurement and Data Analysis of Surfaces with Functionalized Coatings

“…From the biomedical coatings, many advances indicate increasing in this field of study [46]. Further issues are placed with the environment, where eco-friendly perspectives with biodegradable coatings are searched for by many scholars [47,48]. All of the medical studies seem to be different from those with the tribological point of view that many various requirements must be met, such as antibacterial [49] properties.…”