Preliminary Investigation of the Renal Toxicity of Monosodium Glutamate in Rats Determined by Some Serum Biochemical Markers

Renal-Biofunction Potentials of Ethanolic Extract of Solanum Melongena Linn Fruit on Monosodium Glutamate- Intoxicated Rats and Kidney Histology

“…These differences could be accounted on the basis of the MSG concentrations and the rate of exposure. Akanya, et al [14] reported in a preliminary study that as MSG concentration increases, there would be a corresponding increase in the concentration of electrolytes excreted and the same was observed from other reports [16,20]. Potassium homeostasis may also be altered by changes in acid-base balance, insulin and aldosterone and this may result in its poor excretion since it can only be done via the renal system.…”

“…Potassium homeostasis may also be altered by changes in acid-base balance, insulin and aldosterone and this may result in its poor excretion since it can only be done via the renal system. This report by Akanya, et al [14] appears to be true from this finding. Nevertheless, there were no significant differences for the groups 3, 4, 5, and 6 between the groups for the different parameters.…”

“…Monosodium glutamate (MSG), the sodium salt of glutamate is a food additive generally used to improve flavour in foods. MSG has been accepted worldwide as a flavour enhancer and is approved without a daily recommended range as it is generally regarded as a safe product by regulatory bodies even with numerous reported possible adverse effects it could result to Mbah and Egbuonu [12]; Akanya, et al [14]. Flavourings are important in savoury food manufacturing particularly those dealing more on spicy foods as it provides its Umami taste.…”