Preliminary investigation of the anti‐colon cancer activity of cucurbitacin C from cucumber: A network pharmacological study and experimental validation
Jingke Liu,
Xiao Zhang,
Haixia Yang
et al.
Abstract:Colon cancer (CC) is a prevalent malignant tumor of the gastrointestinal tract and ranks among the leading causes of death in cancer patients worldwide. Cucurbitacin, a group of tetracyclic triterpenoids widely found in Cucurbitaceae plants, exhibits diverse pharmacological activities. However, the pharmacological activity of cucurbitacin C (CuC), a cucurbitacin derivative exclusively present in cucumbers, remains unclear. To investigate CuC's action targets and potential targets for CC, we utilized a database… Show more
“…31 As a biological analysis method, network pharmacology can effectively collect and organize information on related proteins and targets, and provide a new method for the mechanistic study of traditional Chinese medicines. 32 Liu et al used network pharmacology to predict relevant targets of Gynostemma chamomin against anti-renal cell carcinoma. 33 It was found that Gynostemma chamomin induced the apoptosis of renal cell carcinoma through the PI3K/AKT/mTOR pathway.…”
Pomegranate peel is the by-product of pomegranate processing, which contains a lot of triterpene compounds. In this study, the total triterpenes of pomegranate peel (TPP) were extracted by optimal conditions...
“…31 As a biological analysis method, network pharmacology can effectively collect and organize information on related proteins and targets, and provide a new method for the mechanistic study of traditional Chinese medicines. 32 Liu et al used network pharmacology to predict relevant targets of Gynostemma chamomin against anti-renal cell carcinoma. 33 It was found that Gynostemma chamomin induced the apoptosis of renal cell carcinoma through the PI3K/AKT/mTOR pathway.…”
Pomegranate peel is the by-product of pomegranate processing, which contains a lot of triterpene compounds. In this study, the total triterpenes of pomegranate peel (TPP) were extracted by optimal conditions...
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