Preliminary Investigation of Calcium Alginate Gel as a Biocompatible Material for Endovascular Aneurysm Embolization in Vivo

Becker, T; Preul, Mark C.; Bichard, William D.; Kipke, Daryl R.; McDougall, Cameron G.

doi:10.1227/01.neu.0000255447.90106.12

Cited by 34 publications

(48 citation statements)

References 30 publications

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“…11 A potential explanation for these (contradictory) findings might be that acute thrombosis induces inflammation on such a large scale that it over-runs the aneurysm wall defense mechanisms or that fibrin biopolymer leads to a thicker clot than normal coagulation. Acute thrombus induction has been linked to mural destabilization not only in experimental aneurysms 22,23 but also in the clinical setting after application of flow diverters to treat intracranial aneurysms. 24,25 These studies consistently found histopathologic characteristics comparable with those found in our study, with large amounts of inflamed cells and mural cells loss in destabilized aneurysm wall segments after rapid thrombosis.…”

Section: Limitationsmentioning

confidence: 99%

“…24,25 These studies consistently found histopathologic characteristics comparable with those found in our study, with large amounts of inflamed cells and mural cells loss in destabilized aneurysm wall segments after rapid thrombosis. 22,23,25 However, the cell loss observed in healthy aneurysms could also be attributed to ischemic or inflammatory reactions induced by the fibrin polymer thrombus. It might also be possible that luminal fibrin polymer lead to a thicker clot than normal coagulation and impaired diffusion of nutrients to the healthy media and promoted inflammation as a secondary reaction.…”

Section: Limitationsmentioning

confidence: 99%

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Intraluminal Cell Transplantation Prevents Growth and Rupture in a Model of Rupture-Prone Saccular Aneurysms

Marbacher

Frösén

Marjamaa

et al. 2014

Stroke

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Background and Purpose-Aneurysm occlusion by intraluminal thrombus formation is the desired effect of all endovascular treatments. Intraluminal thrombus may, however, recanalize and be absorbed, unless it is infiltrated by cells that turn it into fibrous tissue (neointima). Because ruptured aneurysm walls are characterized by loss of smooth muscle cells, we assessed the impact of mural cell loss on wall remodeling of thrombosed aneurysms and investigated whether neointima formation could be enhanced by direct transplantation of cells into the thrombus. Methods-Sidewall aneurysms were microsurgically created in rats (n=81). Certain aneurysms were decellularized.Thrombosis was induced using direct injection of a fibrin polymer into the aneurysm. CM-Dil-labeled smooth muscle cells were injected into 25 of 46 fibrin embolized aneurysms. Recanalization and aneurysm growth were monitored with magnetic resonance angiography. Endoscopy, optical projection tomography, histology, and immunohistochemistry were used to study the fate of transplanted cells, thrombus organization, and neointima formation.

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Section: Limitationsmentioning

confidence: 99%

Section: Limitationsmentioning

confidence: 99%

Intraluminal Cell Transplantation Prevents Growth and Rupture in a Model of Rupture-Prone Saccular Aneurysms

Marbacher

Frösén

Marjamaa

et al. 2014

Stroke

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“…Lateral wall aneurysms were surgically created in the right common carotid artery of canines as previously described. 1,14,15 Prior to embolization, animals were given an intravenous bolus injection of 3000 IU heparin, followed by a maintenance injection of 500 IU every 30 minutes during the procedure to control clotting. Postoperatively, animals were placed on chronic aspirin at a dose of 81.25 mg/day.…”

Section: Surgical Aneurysm Creationmentioning

confidence: 99%

“…Because swine generally have heightened healing responses to embolization, 1,11,20,34,35 in the present study we investigated the embolization of surgically created aneurysms in canines, which respond to coil embolization in a manner similar to humans and thus provide a more clinically relevant in vivo aneurysm model. 4 The PPODA-QT was used to embolize lateral wall aneurysms created in the carotid arteries of canines, which survived for a period of 6 months.…”

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confidence: 99%

In vivo embolization of lateral wall aneurysms in canines using the liquid-to-solid gelling PPODA-QT polymer system: 6-month pilot study

Brennecka

Preul

Becker

et al. 2013

JNS

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Object Over the past 20 years, endovascular embolization has become the preferred method of treating cerebral aneurysms. While there are many embolic devices on the market, none is ideal. In this study the authors investigated the use of a liquid-to-solid gelling polymer system—that is, poly(propylene glycol) diacrylate and pentaerythritol tetrakis (3-mercaptopropionate) (PPODA-QT)—to embolize in vivo aneurysms over a 6-month period. Methods Experimental aneurysms were created in the carotid arteries of 9 canines. Aneurysms were embolized with the polymer only (PPODA-QT, 3 dogs), filled with PPODA-QT after placement of a “framing” platinum coil (coil + PPODA-QT, 3 dogs), or packed with platinum coils (coils only, 3 dogs). Aneurysm occlusion was angiographically monitored immediately and 6 months after embolization. After 6 months, the ostial regions of explanted aneurysms were assessed macroscopically and histologically. Results All aneurysms showed 100% angiographic occlusion at 6 months, but turbulent blood flow was observed in 1 coils-only sample. Ostial regions of explanted coils-only aneurysms showed neointimal tissue surrounding individual coils but no continuous tissue layer over the aneurysm neck. All PPODA-QT aneurysms displayed smooth ostial surfaces, but 2 of 3 coil + PPODA-QT aneurysms showed polymer (unassociated with the coil) protruding into the vessel lumen, contributing to rough ostial surfaces. Neointimal tissue was present in PPODA-QT and coil + PPODA-QT aneurysms and covered smooth ostial surfaces more completely than in coils-only aneurysms. Conclusions This study compared neointimal tissue overgrowth in the ostium of experimental aneurysms embolized with PPODA-QT, PPODA-QT plus a framing coil, or coils alone. The coils-only and coil + PPODA-QT groups showed rough and discontinuous ostial surfaces, which hindered neointimal tissue coverage. The PPODA-QT aneurysms consistently produced smooth ostial surfaces that facilitated more complete neointimal tissue coverage over aneurysm necks.

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“…Aneurysms were surgically created in the right common carotid artery of adult Yorkshire swine (ϳ130 lb) as previously described (3). A lateral wall carotid artery aneurysm was created by making a 10-cm incision on the right side of the animal's neck to access the right common carotid artery and external jugular vein (EJV).…”

Section: Surgical and Endovascular Proceduresmentioning

confidence: 99%

In Vivo Experimental Aneurysm Embolization in a Swine Model with a Liquid-to-Solid Gelling Polymer System: Initial Biocompatibility and Delivery Strategy Analysis

et al. 2012

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Preliminary Investigation of Calcium Alginate Gel as a Biocompatible Material for Endovascular Aneurysm Embolization in Vivo

Cited by 34 publications

References 30 publications

Intraluminal Cell Transplantation Prevents Growth and Rupture in a Model of Rupture-Prone Saccular Aneurysms

Intraluminal Cell Transplantation Prevents Growth and Rupture in a Model of Rupture-Prone Saccular Aneurysms

In vivo embolization of lateral wall aneurysms in canines using the liquid-to-solid gelling PPODA-QT polymer system: 6-month pilot study

In Vivo Experimental Aneurysm Embolization in a Swine Model with a Liquid-to-Solid Gelling Polymer System: Initial Biocompatibility and Delivery Strategy Analysis

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