Preliminary investigation of a biological augmentation of rotator cuff repairs using a collagen implant: a 2-year MRI follow-up

Bokor, Desmond J.; Sonnabend, David H.; Deady, L.; Cass, B.; Young, A.; Kampen, Craig Van; Arnoczky, Steven P.

doi:10.32098/mltj.03.2015.01

Cited by 40 publications

(43 citation statements)

References 27 publications

Supporting

Mentioning

Contrasting

Order By: Relevance

“…An experimental study in sheep has demonstrated the ability of a highly-porous, low modulus, reconstituted collagen implant to consistently increase the thickness of a rotator cuff tendon by inducing the formation of a well-integrated and mature tendon-like tissue 22 . In addition, a recent clinical study has demonstrated the ability of this collagen implant to increase the thickness of the supraspinatus tendon following augmentation of full-thickness, rotator cuff repairs 23 . Therefore, the purpose of the current clinical study was to evaluate the effect of this implant placed arthroscopically on the bursal surface of the supraspinatus tendon in patients with partial-thickness tears.…”

Section: Evidence Of Healing Of Partial-thickness Rotator Cuff Tears mentioning

confidence: 99%

“…The reconstituted collagen scaffolds were made from highly-purified, type I collagen from bovine tendons using proprietary methods (Collagen Matrix, Inc., Oakland, New Jersey) 22,23 . The collagen fibers were processed to create a highly oriented and highly porous (85-90% porosity) collagen scaffold with a DNA content of less than 50 ng/mg 22,23 . The scaffolds were freeze-dried after processing and rehydrated at the time of surgery 22,23 .…”

Section: Collagen Implantmentioning

confidence: 99%

“…The collagen fibers were processed to create a highly oriented and highly porous (85-90% porosity) collagen scaffold with a DNA content of less than 50 ng/mg 22,23 . The scaffolds were freeze-dried after processing and rehydrated at the time of surgery 22,23 . The rehydrated scaffold dimensions were approximately 15 mm wide, 30 mm long, and 2 mm thick 22,23 .…”

Section: Collagen Implantmentioning

confidence: 99%

“…The scaffolds were freeze-dried after processing and rehydrated at the time of surgery 22,23 . The rehydrated scaffold dimensions were approximately 15 mm wide, 30 mm long, and 2 mm thick 22,23 .…”

Section: Collagen Implantmentioning

confidence: 99%

See 3 more Smart Citations

Evidence of healing of partial-thickness rotator cuff tears following arthroscopic augmentation with a collagen implant: a 2-year MRI follow-up

Bokor

Sonnabend

Deady³

et al. 2019

Muscle Ligaments and Tendons J

Self Cite

View full text Add to dashboard Cite

Background: partial-thickness rotator cuff tears frequently enlarge due to increased local strain and often progress to full-thickness tears. Studies suggest the addition of new tendinous tissue to injured cuff tendons would significantly decrease peak strain, possibly protecting against tear progression. The aim of this study was to assess the ability of a highly-porous collagen implant to induce new tissue formation and limit tear progression when placed on the bursal surface of partialthickness cuff tears. Methods: following arthroscopic subacromial decompression, the implant was attached to the bursal surface of the supraspinatus tendon in a prospective series of 13 consecutive patients with intermediate-(3-6 mm) to high-grade (>6 mm) partial-thickness cuff tears (5 articular, 3 bursal, 5 intra-substance). Tendon thickness, defect size, and tendon quality were evaluated using magnetic resonance imaging (MRI) preoperatively and at 3, 6, 12, and 24 months postoperatively. Clinical outcomes were assessed using the Constant and American Shoulder and Elbow Society scores at the same preoperative and follow-up times. All 13 patients completed all follow-up exams (mean length of follow-up 27.0 months, range 23.3-32.0); no patients were lost to follow-up. Results: the implant induced significant new tissue formation in all patients by 3 months (mean increase in tendon thickness 2.2 ± 0.26 mm). This tissue matured over time and became radiologically indistinguishable from the underlying tendon. The partial-thickness cuff tears showed consistent filling of the defects, with complete healing in 7 patients at 12 months, and a progressive improvement in tendon quality in the remaining patients. No tear progression was observed by MRI in any of the patients at 24 months. All clinical scores improved significantly over time. At 24 months, 12 of 13 patients (92%) had satisfactory or better results. Conclusions: the results of this clinical study demonstrated the ability of a highly-porous collagen implant to induce new tendon-like tissue formation and create an environment conductive to the healing of partial-thickness cuff tears.

show abstract

Section: Evidence Of Healing Of Partial-thickness Rotator Cuff Tears mentioning

confidence: 99%

Section: Collagen Implantmentioning

confidence: 99%

Section: Collagen Implantmentioning

confidence: 99%

Section: Collagen Implantmentioning

confidence: 99%

See 2 more Smart Citations

Evidence of healing of partial-thickness rotator cuff tears following arthroscopic augmentation with a collagen implant: a 2-year MRI follow-up

Bokor

Sonnabend

Deady³

et al. 2019

Muscle Ligaments and Tendons J

Self Cite

View full text Add to dashboard Cite

show abstract

“…Sheep studies by Van Kampen et al have shown that placing a highly-porous collagen implant on the bursal surface of the infraspinatus tendon would induce the formation of a fibrovascular tissue resem- bling tendon and result in a significant and consistent thickening of the infraspinatus tendon (23). Following the animal experiments and the finite element studies, the porous collagen implant was used in humans to treat partial thickness cuff tears, and also as an augment to the treatment of full thickness cuff tears (11,24). Subsequent published tissue retrieval studies confirmed that the histological changes seen in human specimens corresponded precisely with the findings of the sheep study of Van Kampen et al (23,25).…”

Section: Discussionmentioning

confidence: 99%

Healing of partial-thickness rotator cuff tears following arthroscopic augmentation with a highly-porous collagen implant: a 5-year clinical and MRI follow-up

Bokor¹,

Sonnabend

Deady³

et al. 2019

Muscle Ligaments and Tendons J

Self Cite

View full text Add to dashboard Cite

Background. The purpose of this study was to review patients with intermediate-and high-grade partial-thickness rotator cuff tears at 5 years following insertion of a highly-porous collagen implant on the bursal surface of the cuff to determine the durability of the clinical results and structural integrity of the healed tendons compared to their previously reported 2-year results. Methods. Eleven of the original 13 patients were examined after 5 years. Clinical scores (Constant and ASES) and MRI evaluations of tendon integrity and quality were compared to the two-year results. Results. All patients demonstrated statistically significant improvement in clinical scores compared to preoperative values. Mean Constant and ASES pain and function scores improved at 5 years but were not statistically different from the two-year scores. Eight of the 11 patients demonstrated no negative change in tendon quality on MRI. However, 3 patients had developed new, asymptomatic tears (1 low-grade articular, 2 low-grade intra-substance) of the supraspinatus tendon. Conclusions. This 5-year follow-up confirms the ongoing clinical benefit of this implant in the treatment of partial-thickness lesions of the rotator cuff and demonstrates ongoing structural tendon improvement, with most repaired tendons intact at five years.

show abstract

Rotator Cuff Repair

Wang¹,

He²

2022

Biofabrication for Orthopedics

View full text Add to dashboard Cite

Preliminary investigation of a biological augmentation of rotator cuff repairs using a collagen implant: a 2-year MRI follow-up

Cited by 40 publications

References 27 publications

Evidence of healing of partial-thickness rotator cuff tears following arthroscopic augmentation with a collagen implant: a 2-year MRI follow-up

Evidence of healing of partial-thickness rotator cuff tears following arthroscopic augmentation with a collagen implant: a 2-year MRI follow-up

Healing of partial-thickness rotator cuff tears following arthroscopic augmentation with a highly-porous collagen implant: a 5-year clinical and MRI follow-up

Rotator Cuff Repair

Contact Info

Product

Resources

About