Preliminary in vitro antimicrobial screening of chemical constituents isolated from the root of Lepleae mayombensis (Meliaceae)

Sidjui, Lazare Sidjui; Tchangoue, Yvan Anderson Ngandjui; Radhakrishnan, Sindhu; Karthiga, Perumal; Djomgoue, Paul; Toghueo, Rufin Marie Kouipou; Famen, Louis Claire Ndel; Annadurai, G.; Ngosong, Gabriel

doi:10.7324/japs.2015.501206

Cited by 2 publications

(3 citation statements)

References 21 publications

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“…NMR data for lanostane-type terpenoids (1)(2)(3)(4) and (11)(12). This material is available free of charge via the internet at http://pubs.acs.org.…”

Section: Supporting Informationmentioning

confidence: 99%

“…Phytochemical studies on this species reveal that triterpenoids are its main constituents. 3 Triterpenoids are the C-30 class of natural products derived from squalene. The biosynthetic origin of most triterpenoids lies in cascade cyclizations and rearrangements of the acyclic precursors squalene (S) and 2,3-oxidosqualene (OS), leading to the tetra-and pentacyclic triterpenoid skeletons.…”

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confidence: 99%

“…This plant is used in African folk medicine for the treatment of cancer and microbial infections. Phytochemical studies on this species reveal that triterpenoids are its main constituents …”

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confidence: 99%

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Bioactive Seco-Lanostane-Type Triterpenoids from the Roots of Leplaea mayombensis

et al. 2017

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Fractionation of the ethyl acetate-soluble extract of the roots of Leplaea mayombensis afforded two new 3,4-seco-lanostane-type triterpenoids, leplaeric acids A and B (1, 2), the new lanostane-type triterpenoid leplaeric acid C (3), and six known natural products (5-10). Derivatization of the main constituent, 1, afforded the dimethyl ester 4, the monoamide 11, and diamide 12 for SAR studies. The structures of these compounds were established through spectroscopic methods, and a single-crystal X-ray diffraction analysis was used to confirm the relative configuration of compound 1. These lanostane derivatives are unique since they are the first C-21-oxygenated lanostanes isolated from plant sources. Preliminary biological assays against the MDA MB 231 breast cancer cell line showed that compounds 1, 2, 4, and 11 have modest cytotoxic activity. Compound 2 was the most active, with an IC of 55 ± 7 μM. From these results, the amides (11, 12) derived from triterpenoid 1 were found to be less active than the derived esters (2, 4).

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“…NMR data for lanostane-type terpenoids (1)(2)(3)(4) and (11)(12). This material is available free of charge via the internet at http://pubs.acs.org.…”

Section: Supporting Informationmentioning

confidence: 99%

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confidence: 99%

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Bioactive Seco-Lanostane-Type Triterpenoids from the Roots of Leplaea mayombensis

et al. 2017

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Antifungal Activities of Some Plant Extracts against Pathogenic Fungi

Easa

Hamdy²,

Mekawey

et al. 2018

Egyptian Academic Journal of Biological Sciences, G. Microbiolo

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Soil samples were collected from different localities in Cairo, and were assayed for keratinophilic fungi. Five species of fungi classified in two genera were isolated from Giza zoo (animal cages and parks), hospital, public park, local market, primary school, club, and garbage dumping site. Five plants were chosen to investigate their antifungal activity against five isolated dermatophytes: Microsporum gypseum, Microsporum boullardii, Trichophyton mentagrophytes, Trichophyton terrsetre, and Trichophyton verrucosum. The tested plants were Punica granatum (Pomegranate), Aloe vera, Foeniculum vulgare (Fennel), Allium ampeloprasum var. Kurrat (kurrat), and Ricinus communis (Castor bean). Plant extracts were prepared by three different solvents, hexane, ethyl acetate, and (80%) ethanol. The study shows that ethanolic extract of Punica granatum (Pomegranate), hexane, and ethanolic extract of Allium ampeloprasum var. Kurrat (kurrat) were effective against most of the tested organisms. Ethanolic extract of pomegranate and hexane extract of kurrat were chromatographed by column chromatography. Fractions from column chromatography were tested for antifungal activity. Ethyl acetate: ethanol (9:1) fraction of pomegranate (Punica granatum) and hexane: ethyl acetate (1:9) fraction of kurrat (Allium ampeloprasum var. Kurrat) showed antifungal activity against the fungal strains. These fractions were analyzed by Gas Chromatography-Mass Spectrum (GC-MS). Saadia M. Hassanin Easa et al.

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Preliminary in vitro antimicrobial screening of chemical constituents isolated from the root of Lepleae mayombensis (Meliaceae)

Cited by 2 publications

References 21 publications

Bioactive Seco-Lanostane-Type Triterpenoids from the Roots of Leplaea mayombensis

Bioactive Seco-Lanostane-Type Triterpenoids from the Roots of Leplaea mayombensis

Antifungal Activities of Some Plant Extracts against Pathogenic Fungi

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