Preliminary in vitro and ex vivo evaluation of afzelin, kaempferitrin and pterogynoside action over free radicals and reactive oxygen species

Vellosa, José Carlos Rebuglio; Regasini, Luís Octávio; Belló, Caroline; Schemberger, Josiane Aparecida; Khalil, Najeh Maissar; Morandim-Giannetti, Andreia de Araújo; Bolzani, Vanderlan da Silva; Brunetti, Iguatemy Lourenço; Oliveira, Olga Maria Mascarenhas de Faria

doi:10.1007/s12272-014-0487-1

Cited by 23 publications

(15 citation statements)

References 28 publications

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“…Thus, the present paper reports the first suggestion of biological activity for this compound. Ellagic acid, kaempferol 3,7-di-O-rhamnoside (kaempferitrin), apigenin-6-C-glucoside (isovitexin) were reported with antioxidant and/or anti-inflammatory activities by several studies [49][50][51][52][53].…”

Section: Discussionmentioning

confidence: 99%

Anti-Inflammatory and Antioxidant Activity of Pollen Extract Collected by Scaptotrigona affinis postica: in silico, in vitro, and in vivo Studies

et al. 2020

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Bees are of great importance for plant diversity for being an important pollinating agents. Stingless bees such as Scaptotrigona affinis postica, is cultivated largely due to the products offered by it. Pollen is one of these products, which has been highlighted for exhibit various therapeutic properties. Considering the bioactivity of this natural product, this study investigated the antioxidant, anti-inflammatory, antinociceptive activities, and elucidated the chemical composition of pollen collected extract by Scaptotrigona affinis postica. Using in vitro assays, the antioxidant potential and inhibitory activity against the COX enzyme from pollen extract was evaluated. Additionally, tests were performed to measure the anti-inflammatory and antinociceptive activities in animal models. In our results, we found that pollen extract showed antioxidant effects and inhibitory activity against the COX enzyme. The in vivo assays showed that the extract acts on the nervous system in local and systemic levels and that the anti-inflammatory activity is due the prostanoids reducing. Chemical analyses recognize 10 molecules in the extract belonging to the polyphenol and flavonoids classes and the computational study suggests that is responsible for the observed results. Thus, it is reported for the first time the biological potential of S. aff. postica pollen extract and we conclude that this bee product can be considered as one source of potential new drugs.

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Section: Discussionmentioning

confidence: 99%

Anti-Inflammatory and Antioxidant Activity of Pollen Extract Collected by Scaptotrigona affinis postica: in silico, in vitro, and in vivo Studies

et al. 2020

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“…Kaempferitrin (Figure a) is a natural flavonoid glycoside that has been found in several edible and medicinal plants (Hamzah, Lajis, & Sargent, ). Kaempferitrin has been reported to possess broad bioactivities, such as antioxidative (Vellosa et al, ), anti‐inflammatory (De Melo et al, ), anticonvulsant (Gonzalez‐Trujano et al, ), antidepressant (Cassani, Dorantes‐Barron, Novales, Real, & Estrada‐Reyes, ), antidiabetic (Da Silva et al, ), and antitumor activities (Alonso‐Castro et al, ). It has been demonstrated that flavonoids have a protective effect against RA, which in part own to its anti‐inflammatory activity (Bala, Chetia, Dolai, Khandelwal, & Haldar, ).…”

Section: Introductionmentioning

confidence: 99%

Kaempferitrin inhibits proliferation, induces apoptosis, and ameliorates inflammation in human rheumatoid arthritis fibroblast‐like synoviocytes

Wang

Zhao

2019

Phytotherapy Research

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Rheumatoid arthritis (RA) is a complex chronic inflammatory disease that is associated with the aberrant activation of fibroblast‐like synoviocytes (FLS). Kaempferitrin is a natural flavonoid glycoside that possesses anti‐inflammatory bioactivity. However, the effect of kaempferitrin on RA has not yet been revealed. The aim of the present study was to investigate the effect of kaempferitrin on human RA‐FLS MH7A cell line. We found that kaempferitrin inhibited proliferation and induced apoptosis of MH7A cells. Kaempferitrin decreased the levels of interleukin (IL)‐1β, IL‐6, tumor necrosis factor (TNF)‐α, matrix metalloproteinase (MMP)‐1, and MMP‐3 in MH7A cells. Moreover, kaempferitrin blocked the activation of nuclear factor‐κB (NF‐κB) and protein kinase B (Akt)/mammalian target of rapamycin (mTOR) pathways. Furthermore, treatment with kaempferitrin decreased paw thickness and arthritis scores, and reduced the serum levels of IL‐1β, IL‐6, and TNF‐α in a collagen‐induced arthritis mouse model. In conclusion, kaempferitrin inhibited cell proliferation, induced cell apoptosis, and ameliorated inflammation of RA‐FLS by suppressing the NF‐κB and Akt/mTOR pathways.

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“…Phenolic compounds isolated from flowers showed myeloperoxidase inhibitory (MPO) and radical scavenging activities 25 . Studies with flavonoids from this plant have demonstrated their antiproliferative effect against melanoma cells 26 , inhibition of MPO 27 , 28 , radical scavenging properties and antioxidant activities 29 – 32 , as well as a potent antifungal activity against opportunistic fungi 33 .…”

Section: Introductionmentioning

confidence: 99%

Flavonoids from Pterogyne nitens Inhibit Hepatitis C Virus Entry

Shimizu

Lima

Pereira

et al. 2017

Sci Rep

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Hepatitis C virus (HCV) is one of the leading causes of liver diseases and transplantation worldwide. The current available therapy for HCV infection is based on interferon-α, ribavirin and the new direct-acting antivirals (DAAs), such as NS3 protease and NS5B polymerase inhibitors. However, the high costs of drug design, severe side effects and HCV resistance presented by the existing treatments demonstrate the need for developing more efficient anti-HCV agents. This study aimed to evaluate the antiviral effects of sorbifolin (1) and pedalitin (2), two flavonoids from Pterogyne nitens on the HCV replication cycle. These compounds were investigated for their anti-HCV activities using genotype 2a JFH-1 subgenomic replicons and infectious virus systems. Flavonoids 1 and 2 inhibited virus entry up to 45.0% and 78.7% respectively at non-cytotoxic concentrations. The mechanism of the flavonoid 2 block to virus entry was demonstrated to be by both the direct action on virus particles and the interference on the host cells. Alternatively, the flavonoid 1 activity was restricted to its virucidal effect. Additionally, no inhibitory effects on HCV replication and release were observed by treating cells with these flavonoids. These data are the first description of 1 and 2 possessing in vitro anti-HCV activity.

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Preliminary in vitro and ex vivo evaluation of afzelin, kaempferitrin and pterogynoside action over free radicals and reactive oxygen species

Cited by 23 publications

References 28 publications

Anti-Inflammatory and Antioxidant Activity of Pollen Extract Collected by Scaptotrigona affinis postica: in silico, in vitro, and in vivo Studies

Anti-Inflammatory and Antioxidant Activity of Pollen Extract Collected by Scaptotrigona affinis postica: in silico, in vitro, and in vivo Studies

Kaempferitrin inhibits proliferation, induces apoptosis, and ameliorates inflammation in human rheumatoid arthritis fibroblast‐like synoviocytes

Flavonoids from Pterogyne nitens Inhibit Hepatitis C Virus Entry

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