Preliminary Imaging Results with 18F-2-Fluoro-2-Deoxy-D-Glucose

Brownell, G.L.; Ackerman, R.H.; Strauß, Harald; Elmaleh, David R.; Cochavi, S.; Alpert, N.M.; Correia, John A.; Kearfott, Kimberlee J.; Taveras, J M

doi:10.1097/00004728-198008000-00013

Cited by 22 publications

(5 citation statements)

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“…In this study, the sensitivity of biokinetic and dosimetric parameters are calculated for the following commonly used radiopharmaceuticals: 18 F-FDG (Hays and Segall 1998;Brownell et al 1980;Deloar et al 1998;Reivich et al 1979;Khamwan et al 2010), 99m Tc-pertechnetate (ICRP 1987;Andros et al 1965;McAfee et al 1964), 99m Tc-phosphonate (ICRP 1987;Subramanian et al 1975), 99m Tc-sestamibi (ICRP 1998;Leide et al 1992;Higley et al 1993), 99m Tc-tetrofosmin (ICRP 1998;Higley et al 1993), 99m Tc-macroaggregated albumin (MAA) (ICRP 1987) and 201 Tl-chloride (ICRP 2008;Atkins et al 1977;Lebowitz et al 1975;Krahwinkel et al 1988;Castronovo 1993;Thomas et al 2005).…”

Section: Radiopharmaceuticals Consideredmentioning

confidence: 99%

Finding sensitive parameters in internal dose calculations for radiopharmaceuticals commonly used in clinical nuclear medicine

Spielmann

Zankl

2018

Radiat Environ Biophys

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Internal dosimetry after incorporation of radionuclides requires standardized biokinetic and dosimetric models. The aim of the present work was to identify the parameters and the components of the models which contribute most to dosimetric uncertainty. For this a method was developed allowing for the calculation of the uncertainties of the absorbed dose coefficients. More specifically, the sampling-based regression method and the variance-based method were used to develop and apply a global method of sensitivity analysis. This method was then used to quantify the impact of various biokinetic and dosimetric parameters on the uncertainty of internal doses associated with the incorporation of seven common radiopharmaceuticals. It turned out that the correlation between biokinetic parameters and time-integrated activity or calculated absorbed dose is strongest when the source and target organ are identical, in accordance with the ICRP and the MIRD approach. According to the ICRP approach, the parameter F which describes the fractional distribution of any incorporated radioactivity to organ S, has the greatest correlation with the time-integrated activity in the corresponding source organ or with the calculated dose in the corresponding target organ. In contrast, the MIRD approach suggested several biokinetic parameters with similar correlation. The dosimetric parameters usually contribute more to uncertainty in the calculated dose coefficients than the biokinetic parameters, in both approaches. The results obtained are helpful for the revision of biokinetic models for radiopharmaceuticals, because the most important parameters in clinical applications can now be identified and investigated in future studies.

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Section: Radiopharmaceuticals Consideredmentioning

confidence: 99%

Finding sensitive parameters in internal dose calculations for radiopharmaceuticals commonly used in clinical nuclear medicine

Spielmann

Zankl

2018

Radiat Environ Biophys

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“…Amongst all the radiopharmaceuticals developed so far for PET imaging, 18 F-fluorodeoxyglucose ( 18 FDG) has widespread application and is most commonly used. Although several dose estimates in humans have been reported from internal administration of 18 FDG, most of these are based on the bio-distribution studies in animals 6 7 8 9 or by combining data from animals and measurements in humans 10 11 12 13 14 15 16 . Kinetics of 18 FDG distribution has also been reported using segmented dynamic PET scan protocols, whole body PET scans at different time intervals or using thermoluminescent dosimeters (TLD) 17 18 19 20 21 22 23 .…”

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confidence: 99%

Estimation of radiation dose to patients from^[18]FDG whole body PET/CT investigations using dynamic PET scan protocol

Kaushik¹,

Jaimini²,

Tripathi³

et al. 2015

Indian J Med Res

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Background & objectives:There is a growing concern over the radiation exposure of patients from undergoing 18FDG PET/CT (18F-fluorodeoxyglucose positron emission tomography/computed tomography) whole body investigations. The aim of the present study was to study the kinetics of 18FDG distributions and estimate the radiation dose received by patients undergoing 18FDG whole body PET/CT investigations.Methods:Dynamic PET scans in different regions of the body were performed in 49 patients so as to measure percentage uptake of 18FDG in brain, liver, spleen, adrenals, kidneys and stomach. The residence time in these organs was calculated and radiation dose was estimated using OLINDA software. The radiation dose from the CT component was computed using the software CT-Expo and measured using computed tomography dose index (CTDI) phantom and ionization chamber. As per the clinical protocol, the patients were refrained from eating and drinking for a minimum period of 4 h prior to the study.Results:The estimated residence time in males was 0.196 h (brain), 0.09 h (liver), 0.007 h (spleen), 0.0006 h (adrenals), 0.013 h (kidneys) and 0.005 h (stomach) whereas it was 0.189 h (brain), 0.11 h (liver), 0.01 h (spleen), 0.0007 h (adrenals), 0.02 h (kidneys) and 0.004 h (stomach) in females. The effective dose was found to be 0.020 mSv/MBq in males and 0.025 mSv/MBq in females from internally administered 18FDG and 6.8 mSv in males and 7.9 mSv in females from the CT component. For an administered activity of 370 MBq of 18FDG, the effective dose from PET/CT investigations was estimated to be 14.2 mSv in males and 17.2 mSv in females.Interpretation & conclusions:The present results did not demonstrate significant difference in the kinetics of 18FDG distribution in male and female patients. The estimated PET/CT doses were found to be higher than many other conventional diagnostic radiology examinations suggesting that all efforts should be made to clinically justify and carefully weigh the risk-benefit ratios prior to every 18FDG whole body PET/CT scan.

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“…\s=b\Initial results in over 50 patients with stroke suggest that positron images made during continuous inhalation of carbon dioxide labeled with oxygen 15 and molecular oxygen labeled with oxygen 15 provide data on tissue function that may be relevant to acute stroke management. Five cases illustrate the following findings: 15O-activity patterns observed in areas of ischemic injury or infarction are what one would expect if the 15O distributions represented physiologic functions, such as cerebral blood flow and metabolism.…”

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confidence: 99%

Positron Imaging in Ischemic Stroke Disease Using Compounds Labeled With Oxygen 15

Ackerman¹

1981

Arch Neurol

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177

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Preliminary Imaging Results with 18F-2-Fluoro-2-Deoxy-D-Glucose

Cited by 22 publications

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Finding sensitive parameters in internal dose calculations for radiopharmaceuticals commonly used in clinical nuclear medicine

Finding sensitive parameters in internal dose calculations for radiopharmaceuticals commonly used in clinical nuclear medicine

Estimation of radiation dose to patients from^[18]FDG whole body PET/CT investigations using dynamic PET scan protocol

Positron Imaging in Ischemic Stroke Disease Using Compounds Labeled With Oxygen 15

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Preliminary Imaging Results with 18F-2-Fluoro-2-Deoxy-D-Glucose

Cited by 22 publications

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Finding sensitive parameters in internal dose calculations for radiopharmaceuticals commonly used in clinical nuclear medicine

Finding sensitive parameters in internal dose calculations for radiopharmaceuticals commonly used in clinical nuclear medicine

Estimation of radiation dose to patients from[18]FDG whole body PET/CT investigations using dynamic PET scan protocol

Positron Imaging in Ischemic Stroke Disease Using Compounds Labeled With Oxygen 15

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Estimation of radiation dose to patients from^[18]FDG whole body PET/CT investigations using dynamic PET scan protocol