Abstract:In traditional pharmacokinetic models, blood flow or liquid transit are often expressed as first-order kinetics. When the flow expression by first-order kinetic are used for dynamic simulation, the flow velocity illogically depends on the step size of a solver of ordinary differential equations. In this study, we propose flow modeling using hybrid automata that combine ordinary differential equations and recursive equations, and preliminarily applied the constructed models to several examples. The blood concen… Show more
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