Preliminary experiment of fluorescent X-ray computed tomography to detect dual agents for biological study

Yu, Quanwen; Takeda, Takeshi; Yuasa, Tetsuya; Hasegawa, Yasuhiro; Wu, Jin; Thet-Thet-Lwin,; Hyodo, Kazuyuki; Dilmanian, F.A.; Itai, Yuji; Akatsuka, Takao

doi:10.1107/s0909049500020483

Cited by 14 publications

(11 citation statements)

References 15 publications

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“…To reduce the background from scattered photons, the detectors are often shielded to restrict the acceptance angle for incoming photons. Up to our knowledge, the 5% overall sensitivity assumed in this study is significantly higher than the detection efficiencies obtained in previously published experimental studies [4, 5, 14, 15, 30, 36–38]. …”

Section: Methodscontrasting

confidence: 63%

“…To achieve a very high energy-resolution with semiconductor detectors, one needs to use relatively long pulse shaping-times, typically at the order of microsecond. This factor limits the count-rate capabilities of semiconductor spectrometers used in current XFCT studies, which is also the key reason for most of experimental XFCT setups to use extensive shielding to limit the detection efficiency to a few percent [4, 5, 14, 15, 30, 36–38]. A possible solution is to surround the object with more detectors collecting photons independently.…”

Section: Conclusion and Discussionmentioning

confidence: 99%

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X-Ray Fluorescence Emission Tomography (XFET) With Novel Imaging Geometries— A Monte Carlo Study

Meng

Rivière

2011

IEEE Trans. Nucl. Sci.

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This paper presents a feasibility study for using two new imaging geometries for synchrotron X-ray fluorescence emission tomography (XFET) applications. In the proposed approaches, the object is illuminated with synchrotron X-ray beams of various cross-sectional dimensions. The resultant fluorescence photons are detected by high-resolution imaging-spectrometers coupled to collimation apertures. To verify the performance benefits of the proposed methods over the conventional line-by-line scanning approach, we have used both Monte Carlo simulations and an analytical system performance index to compare several different imaging geometries. This study has demonstrated that the proposed XFET approach could lead to a greatly improved imaging speed, which is critical for making XFET a practical imaging modality for a wide range of applications.

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Section: Methodscontrasting

confidence: 63%

Section: Conclusion and Discussionmentioning

confidence: 99%

X-Ray Fluorescence Emission Tomography (XFET) With Novel Imaging Geometries— A Monte Carlo Study

Meng

Rivière

2011

IEEE Trans. Nucl. Sci.

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“…FXCT has the possibility to image at the spatial resolution of PET resembling to the approaches of SPECT without the use of non-radioactive elements. The sensitivity of FXCT is about 77 times better than that of the TXCT in the 3-cm diameter phantom [17].…”

Section: -2 Fxct For Live Objectmentioning

confidence: 98%

Medical imaging by fluorescent x-ray CT: its preliminary clinical evaluation

Takeda

Zeniya

et al. 2002

SPIE Proceedings

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Fluorescent x-ray CT (FXCT) with synchrotron radiation (SR) is being developed to detect the very low concentration of specific elements. The endogenous iodine of the human thyroid and the non-radioactive iodine labeled BMIPP in myocardium were imaged by FXCT. FXCT system consists of a silicon (1 1 1) double crystal monochromator, an x-ray slit, a scanning table for object positioning, a fluorescent x-ray detector, and a transmission x-ray detector. Monochromatic x-ray with 37 keV energy was collimated into a pencil beam (from 1 mm to 0.025 mm).FXCT clearly imaged endogenous iodine of thyroid and iodine labeled BMIPP in myocardium, whereas transmissionx-ray CT could not demonstrate iodine. The distribution of iodine was heterogeneous within thyroid cancer, and its concentration was lower than that of normal thyroid. Distribution of BMIPP in normal rat myocardium was almost homogeneous, however reduced uptake was slightly shown in ischemic region. FXCT is a highly sensitive imaging modality to detect very low concentration of specific element and will be applied to reveal endogenous iodine distribution in thyroid and to use tracer study with various kinds of labeled material.

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“…This technique was used to develop quantitative dual-energy x-ray imaging [12] (e.g., fluorescent x-ray computed tomography (FXCT) with synchrotron radiation). One phantom study reported that FXCT could clearly image the distribution of both iodine and xenon agents, and the contrast ratio was significantly better than that of the transmission CT images [13]. To quantitatively select the iodine concentration in the slice, one study's scans used three heavily filtered x-ray beams: two had mean energies that straddle the iodine K-edge (33 keV) and the third energy was slightly higher.…”

Section: Introductionmentioning

confidence: 99%

Determination of Linear X-Ray Attenuation Coefficients of Pathological Brain Tissues and Use of Filters in Tissue Contrast Enhancement in Computed Tomography

Sagsoz

Erdoğan

et al. 2010

EAJM

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Objective: X-ray attenuation coeffi cients are used in common radiological, pathological and spectroscopic examinations and in the determination of the radiation dose distribution in biological tissues. In radiology, these coeffi cients enable diagnosis by diff erentiating the abnormal tissues from the normal ones using their morphological structure and contrast diff erences. In this study, our aim is to precisely determine the linear x-ray attenuation coeffi cients of pathological brain tissues and to use x-ray beam fi lters to enhance the tissue contrast in computed tomography. Materials and Methods:To directly measure the relative linear attenuation coeffi cients, an energy dispersive x-ray spectroscopy system (EDXRS-Canberra, Si(Li) with DSA-1000 spectrum analyzer 1998; CT, USA) was used with collimators and a medical-purpose x-ray tube (Siemens, Siremobil, 1985; Erlangen, Germany) in a linear geometry.Results: Using a Mo fi lter with Computed Tomography CT and photon energies from 15 to 25 keV, EDXRS acquisitions were found to signifi cantly distinguish grades of brain tumors (p<0.05). For the data acquired from CT systems with the decreasing fi ltered photon mean energy, the x-ray attenuation coeffi cients (i.e., the Hounsfi eld units) show that the ratio of EDXRS to CT for water's attenuation coeffi cient are increased. With our suggested x-ray fi lters, the tissue contrast has been found to be increased in ex vivo brain tumor slices compared with slices scanned in conventional CT scanners.Conclusion: X-ray attenuations measured with the EDXRS are found to be statistically more reliable because of the length of acquisition times in this study.

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Preliminary experiment of fluorescent X-ray computed tomography to detect dual agents for biological study

Cited by 14 publications

References 15 publications

X-Ray Fluorescence Emission Tomography (XFET) With Novel Imaging Geometries— A Monte Carlo Study

X-Ray Fluorescence Emission Tomography (XFET) With Novel Imaging Geometries— A Monte Carlo Study

Medical imaging by fluorescent x-ray CT: its preliminary clinical evaluation

Determination of Linear X-Ray Attenuation Coefficients of Pathological Brain Tissues and Use of Filters in Tissue Contrast Enhancement in Computed Tomography

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