Preliminary experience with in vitro fertilization-surrogate gestational pregnancy

Utian, Wulf H.; Goldfarb, J.; Kiwi, Robert; Sheean, Leon A.; Auld, Heather; Lisbona, Hanna

doi:10.1016/s0015-0282(16)60977-9

Cited by 44 publications

(17 citation statements)

References 6 publications

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“…It remains to be determined whether the obstetric risks are the same as those for any other pregnancy derived by IVF or insemination with the same number of fetuses. Most case series report no increase in adverse events related to surrogate pregnancy 1,2,15–18 . In a recent report, however, 2 out of 9 surrogate mothers had a postpartum hysterectomy: the first for placenta accreta following delivery of triplets; the second following uterine rupture during the delivery of a macrosomic infant 2,19 .…”

Section: Health Risks To the Surrogate Mothermentioning

confidence: 99%

Surrogate pregnancy: an essential guide for clinicians

Bhatia¹,

Martindale

Rustamov

et al. 2009

The Obstetric & Gynaecologis

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The incidence of surrogacy is rising. Literature on associated obstetric risks is scarce and caution must be exercised when labelling surrogate pregnancies as low risk. Although obstetricians’ responsibilities lie with the surrogate mother, they must ensure her wishes do not conflict with the best interests of the baby. Prepregnancy counselling is the key to a successful surrogacy arrangement. Learning objectives: To gain an awareness of the different types of surrogacy. To understand the law surrounding surrogacy. To learn about antenatal, intrapartum and postpartum care in surrogacy. Ethical issues: When the surrogate mother's wishes and the interests of the child conflict, do obstetricians have the right to discuss this with the commissioning parents without her consent? When should obstetricians seek ethical and legal support? Please cite this article as: Bhatia K, Martindale EA, Rustamov O, Nysenbaum AM. Surrogate pregnancy: an essential guide for clinicians. The Obstetrician & Gynaecologist 2009;11:49–54.

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Section: Health Risks To the Surrogate Mothermentioning

confidence: 99%

Surrogate pregnancy: an essential guide for clinicians

Bhatia¹,

Martindale

Rustamov

et al. 2009

The Obstetric & Gynaecologis

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“…A successful pregnancy following in vitro fertilization (IVF) and embryo transfer to a gestational carrier was first reported by Utian et al (1985). Since then, the same author (Utian et al 1989) has reported his experience with 39 cycles in 28 couples: indications included uterine absence or anomaly (both congenital and acquired); the clinical pregnancy rate of 18% (7 out of 39) compared favourably with the conventional IVF pregnancy rates reported between 1985 and 1989. More experience with the dissociation of the oocyte donor and the gestational carrier has been acquired with egg donation to patients producing poor-quality oocytes or none at all, and results are actually superior to those of conventional IVF (Sauer and Paulson 1992).…”

Section: Discussionmentioning

confidence: 99%

Gestational carrier — A reproductive haven for offspring of mothers with phenylketonuria (PKU): An alternative therapy for maternal PKU

Fisch

Tagatz

Stassart

1993

J of Inher Metab Disea

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Maternal phenylketonuria, PKU, has a detrimental effect on embryogenesis. Infant pathology is independent of fetal genotype, but is directly correlated with excessive phenylalaninaemia throughout pregnancy. Although normal children have been delivered by affected mothers who either had benign hyperphenylalaninaemia or in whom strict diet has apparently maintained maternal phenylalaninaemia in the low normal range from before conception, more abnormal than normal births have been reported. In addition, attempts at dietary management are often unsuccessful; most reported cases documented various severe pathological consequences of maternal PKU. Currently available methods provide viable alternative treatment. In vitro fertilization using the parental gametes, followed by implantation of the pre-embryo in a surrogate mother, would avoid a metabolic environment impairing normal development, and therefore should be recommended as alternative therapy for potential mothers with PKU.

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“…Most case series report no increase in adverse events related to surrogate pregnancy. 10,[18][19][20][21][22] However, in a recent report, 2 of 9 surrogate mothers underwent postpartum hysterectomy: after a delivery of triplets with placenta accreta and after uterine rupture that occurred during delivery of a macrosomic infant. 23 The limited amount of evidence about the risks associated with surrogate pregnancy has 2 implications: (a) health care providers should have a high index of suspicion for complications and a low threshold for investigations and referral to higher levels of care; and (b) if complications occur, health care providers should report the complications to the centre that initiated the pregnancy so that surrogacy outcomes can be tracked and a better evidence base can be built.…”

Section: Prenatal Care Of the Surrogatementioning

confidence: 99%

Surrogate pregnancy: a guide for Canadian prenatal health care providers

Reilly¹

2007

Canadian Medical Association Journal

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Preliminary experience with in vitro fertilization-surrogate gestational pregnancy

Cited by 44 publications

References 6 publications

Surrogate pregnancy: an essential guide for clinicians

Surrogate pregnancy: an essential guide for clinicians

Gestational carrier — A reproductive haven for offspring of mothers with phenylketonuria (PKU): An alternative therapy for maternal PKU

Surrogate pregnancy: a guide for Canadian prenatal health care providers

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