Preliminary Experience in Treatment of Papillary and Macular Retinoblastoma: Evaluation of Local Control and Local Complications After Treatment With Linear Accelerator-Based Stereotactic Radiotherapy With Micromultileaf Collimator as Second-Line or Salvage Treatment After Chemotherapy

Pica, Alessia; Moeckli, Raphaël; Balmer, Aubin; Beck‐Popovic, Maja; Chollet-Rivier, Madeleine; Do, Huu-Phuoc; Weber, Damien Charles; Munier, Francis L.

doi:10.1016/j.ijrobp.2010.07.033

Cited by 13 publications

(14 citation statements)

References 25 publications

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“…Persistent obscuration does, however, remain a poor prognostic sign both for globe salvage (50%, on par with salvage rates for Group D eyes treated with chemoreduction [11]) and for vision in the salvaged eye. While there are no clear guidelines for management in these rare cases, there are reports of stereotactic radiation for peripapillary tumors [17]. While successful, we recommend radiation therapy only if there is some visual potential to the eye and the child is older than 12 months of age.…”

Section: Discussionmentioning

confidence: 99%

Optic Nerve Obscuration in Retinoblastoma: A Risk Factor for Optic Nerve Invasion

et al. 2017

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Background: The objective of this study is to evaluate the risk of optic nerve invasion associated with optic nerve obscuration at diagnosis or persisting during treatment. Methods: Retrospective review from 2011-2016 of patients with advanced retinoblastoma (Group D/E) with complete obscuration of the nerve at diagnosis and a second group of patients with persistent, complete obscuration throughout treatment. Results: Advanced retinoblastoma was diagnosed in 102 eyes of 86 patients. The optic nerve was obscured in 69 eyes (68%) at diagnosis. Of these, 30 (43%) underwent salvage therapy and 39 (57%) primary enucleation. Histopathologic analysis of primarily enucleated eyes showed 41% prelaminar and 15% postlaminar invasion. Four eyes in the salvage group demonstrated persistent nerve obscuration; 2 were subsequently enucleated without evidence of nerve invasion. Average follow-up was 23.5 months (range 1-62 months). Conclusions and Relevance: Optic nerve obscuration at diagnosis may be associated with postlaminar optic nerve invasion. While persistent, complete obscuration of the optic nerve by retinoblastoma during treatment is a poor prognostic sign for both globe salvage and vision, it does not appear, in this small cohort, to increase the risk of optic nerve invasion. With appropriate control of the intraocular tumor, these eyes can be salvaged.

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Section: Discussionmentioning

confidence: 99%

Optic Nerve Obscuration in Retinoblastoma: A Risk Factor for Optic Nerve Invasion

et al. 2017

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“…Papillary, or peripapillary, Rb was previously described, but only in a handful of studies,8 9 all before HHSD-OCT was available and before IAC and IViC became common clinical practice. Sahgal et al 8 treated cases of posterior pole Rb, four of which were peripapillary (two were perimacular tumours), with stereotactic EBRT.…”

Section: Discussionmentioning

confidence: 99%

“…Sahgal et al 8 treated cases of posterior pole Rb, four of which were peripapillary (two were perimacular tumours), with stereotactic EBRT. Pica and colleagues, similarly, treated 15 eyes with posterior pole Rb with stereotactic EBRT, 9 of which had a papillary component (of these, 5 tumours had also a macular component) 9. Both studies focused on radiotherapy outcomes, but tumour dimensions or exact anatomical locations with regard to the ONH were not provided, indicating only that tumours were papillary, macular, peripapillary or perimacular.…”

Section: Discussionmentioning

confidence: 99%

“…We have designated this condition as secondary epipapillary Rb. In a literature search, only a handful of reports were found that focused on epipapillary, as a subgroup of posterior pole, Rb 8 9. These studies were performed in the pre-HHSD-OCT, pre-targeted chemotherapy era, and overall the treatment modalities used were EBRT and/or enucleation.…”

Section: Introductionmentioning

confidence: 99%

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Diagnosis and management of secondary epipapillary retinoblastoma

et al. 2017

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Cases of retinoblastoma relapse at the ONH show common clinical features and represent specific diagnostic and therapeutic challenge; hence, we propose to consider this condition as a subset of retinoblastoma, termed secondary epipapillary retinoblastoma. HHSD-OCT is an invaluable diagnostic tool in the initial diagnosis as well as in monitoring these lesions, and IAC and IViC are efficient modalities for this clinical scenario, obviating the need for EBRT or enucleation.

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“…These side effects are particularly serious because children are in an active phase of development during the treatment. Other disadvantages include the induction of multidrug resistance induced by the high-dose chemotherapy used to treat RB (7,8). Therefore, finding a new method to treat RB effectively has become a priority.…”

Section: Introductionmentioning

confidence: 99%

Cytokine-induced killer cells co-cultured with complete tumor antigen-loaded dendritic cells, have enhanced selective cytotoxicity on carboplatin-resistant retinoblastoma cells

et al. 2013

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Abstract. Retinoblastoma (RB) is a challenging disease that affects mostly young children. Chemical therapy has been shown to have limitations during clinical practice, principally because of the ability of RB to become resistant to the treatment. Nevertheless, chemotherapy is still the main treatment for RB, and immunotherapy has become a promising treatment for most solid tumors with fewer side effects than traditional therapies. In this study, we explored the antitumor effects of cytokine-induced killer (CIK) cells co-cultured with dendritic cells (DCs) pulsed with complete tumor antigens (DC-Ag). Cytotoxicity and specificity were evaluated on an RB cell line (RB-Y79), on a human normal retina cell line (hTERT-RPE1) and a carboplatin-resistant RB cell line. Our results showed that CIK differentiation and cytotoxicity were enhanced by co-culturing CIKs with DC-Ag. Moreover, the co-culture improved the CIK proliferation rate by increasing IL-6 and decreasing IL-10 levels in the culture medium. Furthermore, the use of DC-Ag-CIK cells had little effect on normal retinal cells but high cytotoxicity on RB cells even on carboplatinresistant retinoblastoma cells. This is the first study showing that DC cells pulsed with the complete tumor antigen improve proliferation, differentiation and cytotoxic activity of CIKs specific not only for RB but also for the chemotherapy-resistant form of the malady. Thus highly efficient immunotherapy based on DC-Ag-CIK cells may be a potential effective and safe mean of treating RB especially to patients where traditional chemical therapy has failed.

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Preliminary Experience in Treatment of Papillary and Macular Retinoblastoma: Evaluation of Local Control and Local Complications After Treatment With Linear Accelerator-Based Stereotactic Radiotherapy With Micromultileaf Collimator as Second-Line or Salvage Treatment After Chemotherapy

Cited by 13 publications

References 25 publications

Optic Nerve Obscuration in Retinoblastoma: A Risk Factor for Optic Nerve Invasion

Optic Nerve Obscuration in Retinoblastoma: A Risk Factor for Optic Nerve Invasion

Diagnosis and management of secondary epipapillary retinoblastoma

Cytokine-induced killer cells co-cultured with complete tumor antigen-loaded dendritic cells, have enhanced selective cytotoxicity on carboplatin-resistant retinoblastoma cells

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