Preliminary Evidence of Genetic Control of Sex Chromosomal Synapsis in the Mouse

Blecher, Stan R.; Gollapudi, B Bhaskar; Kamra, Om P.

doi:10.1139/g81-018

Cited by 2 publications

(1 citation statement)

References 8 publications

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“…Of the strains investigated in this study, only CBA and C57 were previously tested for chromosome univalency. Similarly to the present findings, the C57 strain has been consistently mentioned as having low frequency of X-Y (67%) and autosome (1-2%) dissociation [Blecher et al, 1981;Matsuda et al, 1982;Lbtard et al, 19871, although different substrains were used. The agreement is not so good with respect to the CBA strain.…”

Section: Discussionsupporting

confidence: 87%

X‐Y chromosome dissociation in mouse strains difering in efficiency of spermatogenesis: Elevated frequency of univalents in pubertal males

Krzanowska

1989

Gamete Research

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Dissociation of the X-Y chromosome bivalent in diakinesis-metaphase I spermatocytes of adult mice was significantly more frequent in the CBA strain (29%) than in C57, KP, or KE strains (7-11%). Autosome dissociation (1-5%) involved only the smallest chromosome pairs. Elevated frequency of X-Y dissociation in the CBA strain correlates with significantly lower testes weight and lower yield of spermatogenesis, which suggests that sex bivalent dissociation may be responsible for some loss of spermatogenic cells. However, sperm quality is not affected, the percentage of normal spermatozoa and their fertilizing capacity being higher in CBA than in the remaining strains. Two congenic strains, KE and KE.CBA (the latter with the Y chromosome introduced from CBA), had the same level of X-Y dissociation, suggesting that the Y chromosome plays no role in the determination of this character. In comparison with adult males, pubertal (27-29 day-old) males had twice as high a frequency of X-Y dissociation in KE and KP strains, and combined frequencies of dissociated sex and autosome bivalents were significantly higher in pubertal males of all tested strains. Although the level of chromosome dissociation is not sufficient to explain increased mortality of germ cells observed in pubertal males, it could be one of the contributing factors.

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Section: Discussionsupporting

confidence: 87%

X‐Y chromosome dissociation in mouse strains difering in efficiency of spermatogenesis: Elevated frequency of univalents in pubertal males

Krzanowska

1989

Gamete Research

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Sex vesicle loss: A possible explanation of the excess of XO over XXY conceptuses in mice and men

Ashley¹

1983

Hum Genet

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Preliminary Evidence of Genetic Control of Sex Chromosomal Synapsis in the Mouse

Cited by 2 publications

References 8 publications

X‐Y chromosome dissociation in mouse strains difering in efficiency of spermatogenesis: Elevated frequency of univalents in pubertal males

X‐Y chromosome dissociation in mouse strains difering in efficiency of spermatogenesis: Elevated frequency of univalents in pubertal males

Sex vesicle loss: A possible explanation of the excess of XO over XXY conceptuses in mice and men

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