Preliminary evidence for digit span performance validity indicators within the neuropsychological assessment battery

Varela, Jacob L.; Ord, Anna S.; Phillips, Jacob I; Shura, Robert D.; Sautter, Scott W.

doi:10.1080/23279095.2022.2076602

Cited by 2 publications

(2 citation statements)

References 29 publications

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“…In this study, parallel forms of RAVLT's words were used (e.g., tenda, tamburo, etc., and violino, bastone, etc.). The Digit Span Forward (Digit Span F) and Backward (Digit Span B) tasks to evaluate the memory span: the verbal memory of short-term digits and working memory standardized for Italian population [ 37 , 38 ] (these are subsets of the Wechsler Adult Intelligence Scale-Fourth Edition [WAIS-IV] [ 39 ]). The Symbol Digit Modality Test (SDMT) to measure attention and processing speed [ 40 ].…”

Section: Methodsmentioning

confidence: 99%

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Acute effects of a chewable beetroot-based supplement on cognitive performance: a double-blind randomized placebo-controlled crossover clinical trial

Vaccaro,

Innocenti,

Cione

et al. 2023

Eur J Nutr

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Background Dietary nitrate (NO3−) has been shown to be useful as an ergogenic aid with potential applications in health and disease (e.g., blood pressure control). However, there is no consensus about the effects of dietary NO3− or beetroot (BR) juice supplementation on cognitive function. Objective The aim of this study was to evaluate the effects of a single dose of a chewable BR-based supplement on cognitive performance. Methods A double-blind randomized placebo-controlled two-period crossover clinical trial was carried out based on the extension of the CONSORT guidelines for randomized crossover trials. A total of 44 participants (24 F; 20 M; 32.7 [12.5] years; 66.3 [9.0] kg; 170 [9.2] cm; 22.8 [1.4] kg/m2) were randomly allocated to receive first either four BR-based chewable tablets (BR-CT) containing 3 g of a Beta vulgaris extract (RedNite®) or four tablets of a placebo (maltodextrin). A 4-day washout period was used before crossover. Ninety minutes after ingestion of the treatments, a neuropsychological testing battery was administered in each period. The trial was registered at clinicaltrials.gov NCT05509075. Results Significant improvements with moderate effect size were found on memory consolidation at the short and long term only after BR-CT supplementation via the Rey Auditory Verbal Learning Test immediate (+ 20.69%) and delayed (+ 12.34%) recalls. Likewise, enhancement on both frontal lobe functions (+ 2.57%) and cognitive flexibility (+ 11.16%) were detected after BR-CT. There was no significant change (p < 0.05) on verbal memory of short-term digits, working memory and information processing speed. Mixed results were found on mood and anxiety through the Beck Depression Inventory-II (BDI-II) and the State-Trait Anxiety Inventory (STAI-Y1 and STAI-Y2); however, sequence and period effects were seen on STAI-Y2. Conclusions The acute administration of a chewable BR-based supplement improves certain aspects of cognitive function in healthy females and males, particularly memory capacity and frontal skills.

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Section: Methodsmentioning

confidence: 99%

“…The Digit Span Forward (Digit Span F) and Backward (Digit Span B) tasks to evaluate the memory span: the verbal memory of short-term digits and working memory standardized for Italian population [ 37 , 38 ] (these are subsets of the Wechsler Adult Intelligence Scale-Fourth Edition [WAIS-IV] [ 39 ]).…”

Section: Methodsmentioning

confidence: 99%

Acute effects of a chewable beetroot-based supplement on cognitive performance: a double-blind randomized placebo-controlled crossover clinical trial

Vaccaro,

Innocenti,

Cione

et al. 2023

Eur J Nutr

View full text Add to dashboard Cite

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Understanding the association between fatigue and neurocognitive functioning in patients with glioma: A cross-sectional multinational study

Röttgering,

Taylor,

Brie

et al. 2024

Neuro-Oncology Practice

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Background Fatigue and neurocognitive impairment are highly prevalent in patients with glioma, significantly impacting health-related quality of life. Despite the presumed association between these two factors, evidence remains sparse. Therefore, we aimed to investigate this relationship using multinational data. Methods We analyzed data on self-reported fatigue and neurocognitive outcomes from postoperative patients with glioma from the University of California San Francisco (n = 100, UCSF) and Amsterdam University Medical Center (n = 127, Amsterdam UMC). We used multiple linear regression models to assess associations between fatigue and seven (sub)domains of neurocognitive functioning and latent profile analysis to identify distinct patterns of fatigue and neurocognitive functioning. Results UCSF patients were older (median age 49 vs. 43 years, p = 0.002), had a higher proportion of grade 4 tumors (32% vs. 18%, p = 0.03), and had more neurocognitive deficits (p = 0.01). While the number of clinically fatigued patients was similar between sites (64% vs. 58%, p = 0.12), fatigue and the number of impaired neurocognitive domains were not correlated (p = 0.16-0.72). At UCSF, neurocognitive domains were not related to fatigue, and at Amsterdam UMC attention and semantic fluency explained only 4 to 7% of variance in fatigue. Across institutions, we identified four distinct patterns of neurocognitive functioning, which were not consistently associated with fatigue. Conclusion Although individual patients might experience both fatigue and neurocognitive impairment, the relationship between the two is weak. Consequently, both fatigue and neurocognitive functioning should be independently assessed and treated with targeted therapies.

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Preliminary evidence for digit span performance validity indicators within the neuropsychological assessment battery

Cited by 2 publications

References 29 publications

Acute effects of a chewable beetroot-based supplement on cognitive performance: a double-blind randomized placebo-controlled crossover clinical trial

Acute effects of a chewable beetroot-based supplement on cognitive performance: a double-blind randomized placebo-controlled crossover clinical trial

Understanding the association between fatigue and neurocognitive functioning in patients with glioma: A cross-sectional multinational study

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