Preliminary evidence for an association between intake of high‐fat high‐sugar diet, variations in peripheral dopamine precursor availability and dopamine‐dependent cognition in humans

Hartmann, Hendrik; Pauli, Larissa; Janssen, Loes; Ceglarek, Uta; Horstmann, Annette

doi:10.1111/jne.12917

Cited by 27 publications

(21 citation statements)

References 80 publications

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“…Healthy eating can protects one's mental health and mood, particularly in challenging and stressful times 19-trait curiosity -who typically explore less and regulate their emotions less well, may be particularly susceptible to the negative effects of high-sugar 38 . Consistent with this, previous studies have linked high-sugar/fat intake to enhanced anxiety (for review, 39 ) and changes in dopamine precursor availability 40 . Possibly, curiosity compensates the effects of sugar on anxiety through its effect on positive mood, motivation and enhanced mesolimbic dopamine activity 8,27 .…”

Section: Discussionsupporting

confidence: 74%

Curiosity for information predicts well-being during COVID-19 Pandemic: Contributions of loneliness and daily lifestyle

Vermeer¹,

Muth²,

Terenzi³

et al. 2021

Preprint

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The COVID-19 pandemic confronted humans with high uncertainty and lockdowns, which severely disrupted people’s daily social and health lifestyles, enhanced loneliness and reduced well-being. Curiosity and information-seeking are central to behavior, fostering well-being and adaptation in changing environments. They may be particularly important to maintain well-being during the pandemic. Here, we investigated which motives drive information-seeking, and whether and how curiosity and information-seeking related to well-being and mood (excitement, anxiety). Additionally, we tested whether daily diet contributed to this relationship during lockdown. Participants (N=183) completed questionnaires measuring curiosity, information-seeking, social and mental health. Using a smartphone app, participants submitted their daily food intake and lifestyle ratings for a week. We found participants had highest motivation to seek positive (vs. negative) information, concerning themselves more than others. Both trait curiosity and information-seeking predicted higher well-being, by reduced loneliness. Trait curiosity also predicted well-being and excitement days later. Considering diet, people with lower curiosity consumed food high in dopamine precursor tyrosine, whereas high-sugar intake increased anxiety, only in people with relatively low, but not high, trait curiosity. Taken together, curiosity and information-seeking may benefit well-being and mood in high uncertain and challenging times, by interacting with lifestyle measures (loneliness and nutrition).

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Section: Discussionsupporting

confidence: 74%

Curiosity for information predicts well-being during COVID-19 Pandemic: Contributions of loneliness and daily lifestyle

Vermeer¹,

Muth²,

Terenzi³

et al. 2021

Preprint

View full text Add to dashboard Cite

show abstract

“…This suggests that high trait curiosity may buffer negative effects of high sugar on mood, whereas individuals low in trait curiosity—who typically explore less and regulate their emotions less well, may be particularly susceptible to the negative effects of high sugar 43 . Consistent with this, previous studies have linked high-sugar/fat intake to enhanced anxiety (for review 44 ) and changes in dopamine precursor availability 45 . Possibly, curiosity compensates for the effects of sugar on anxiety through its effect on positive mood, motivation, and enhanced mesolimbic dopamine activity 8 , 28 .…”

Section: Discussionsupporting

confidence: 72%

Curiosity for information predicts wellbeing mediated by loneliness during COVID-19 pandemic

Vermeer

Muth

Terenzi

et al. 2022

Sci Rep

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The COVID-19 pandemic confronted humans with high uncertainty and lockdowns, which severely disrupted people’s daily social and health lifestyles, enhanced loneliness, and reduced well-being. Curiosity and information-seeking are central to behavior, fostering well-being and adaptation in changing environments. They may be particularly important to maintain well-being during the pandemic. Here, we investigated which motives drive information-seeking, and whether and how curiosity and information-seeking related to well-being and mood (excitement, anxiety). Additionally, we tested whether daily diet contributed to this relationship during lockdown. Participants (N = 183) completed questionnaires measuring curiosity, information-seeking, social and mental health. Using a smartphone app, participants submitted their daily food intake and lifestyle ratings for a week. We found participants had highest motivation to seek positive (vs. negative) information, concerning themselves more than others. Both trait curiosity and information-seeking predicted higher well-being, mediated by loneliness. Trait curiosity also predicted well-being and excitement days later. Considering diet, participants with lower trait curiosity ate food containing more tyrosine (i.e., dopamine precursor). Furthermore, participants consuming food high in sugar reported higher anxiety, which was specifically found in participants with relatively low, but not high, trait curiosity. Taken together, curiosity and information-seeking may benefit well-being and mood in high uncertain and challenging times, by interacting with lifestyle measures (loneliness and nutrition).

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“…Long-term sugar consumption produced cocaine-like effects, changes in striatal D1 and D2 receptors, and changes in mood, possibly through its ability to induce reward and pleasure [ 105 , 119 , 120 , 122 , 143 ]. Additionally, the availability of DA precursors may be altered by prolonged consumption of HSD [ 191 ]. Sugar consumption produces cocaine-like effects, changes in striatal D1 and D2 receptors, and changes in mood, possibly through its ability to induce reward and pleasure, leading to sugar-seeking behaviour [ 119 , 120 , 121 , 123 ].…”

Section: Hsd As a Risk Factor To Develop Sud And Food Addictionmentioning

confidence: 99%

A High-Sugar Diet Consumption, Metabolism and Health Impacts with a Focus on the Development of Substance Use Disorder: A Narrative Review

2022

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Carbohydrates are important macronutrients in human and rodent diet patterns that play a key role in crucial metabolic pathways and provide the necessary energy for proper body functioning. Sugar homeostasis and intake require complex hormonal and nervous control to proper body energy balance. Added sugar in processed food results in metabolic, cardiovascular, and nervous disorders. Epidemiological reports have shown enhanced consumption of sweet products in children and adults, especially in reproductive age and in pregnant women, which can lead to the susceptibility of offspring’s health to diseases in early life or in adulthood and proneness to mental disorders. In this review, we discuss the impacts of high-sugar diet (HSD) or sugar intake during the perinatal and/or postnatal periods on neural and behavioural disturbances as well as on the development of substance use disorder (SUD). Since several emotional behavioural disturbances are recognized as predictors of SUD, we also present how HSD enhances impulsive behaviour, stress, anxiety and depression. Apart from the influence of HSD on these mood disturbances, added sugar can render food addiction. Both food and addictive substances change the sensitivity of the brain rewarding neurotransmission signalling. The results of the collected studies could be important in assessing sugar intake, especially via maternal dietary patterns, from the clinical perspective of SUD prevention or pre-existing emotional disorders. Methodology: This narrative review focuses on the roles of a high-sugar diet (HSD) and added sugar in foods and on the impacts of glucose and fructose on the development of substance use disorder (SUD) and on the behavioural predictors of drugs abuse. The literature was reviewed by two authors independently according to the topic of the review. We searched the PubMed and Scopus databases and Multidisciplinary Digital Publishing Institute open access scientific journals using the following keyword search strategy depending on the theme of the chapter: “high-sugar diet” OR “high-carbohydrate diet” OR “sugar” OR “glucose” OR “fructose” OR “added sugar” AND keywords. We excluded inaccessible or pay-walled articles, abstracts, conference papers, editorials, letters, commentary, and short notes. Reviews, experimental studies, and epidemiological data, published since 1990s, were searched and collected depending on the chapter structure. After the search, all duplicates are thrown out and full texts were read, and findings were rescreened. After the selection process, appropriate papers were included to present in this review.

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Preliminary evidence for an association between intake of high‐fat high‐sugar diet, variations in peripheral dopamine precursor availability and dopamine‐dependent cognition in humans

Abstract: This is an open access article under the terms of the Creative Commons Attribution License, which permits use, distribution and reproduction in any medium, provided the original work is properly cited.

Cited by 27 publications

References 80 publications

Curiosity for information predicts well-being during COVID-19 Pandemic: Contributions of loneliness and daily lifestyle

Curiosity for information predicts well-being during COVID-19 Pandemic: Contributions of loneliness and daily lifestyle

Curiosity for information predicts wellbeing mediated by loneliness during COVID-19 pandemic

A High-Sugar Diet Consumption, Metabolism and Health Impacts with a Focus on the Development of Substance Use Disorder: A Narrative Review

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