Preliminary Evaluation of Virtual Touch Tissue Imaging Quantification for Differential Diagnosis of Metastatic and Nonmetastatic Cervical Lymph Nodes

Zhao, Yingyan; Xi, Jiaying; Zhao, Bin; Xiong, Weining; Dong, Jianying; Li, Yang; Cai, Zhuhong; Liu, Tianjia; Jiang, Haibo; Shu, Rong; Jin, Xiucai

doi:10.7863/ultra.16.03077

Cited by 10 publications

(14 citation statements)

References 25 publications

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“…In a meta-analysis of eight studies, malignant nodes are stiffer (higher elasticity and higher speed) than benign nodes and the final results of the studies conclude that SWE for diagnosing malignant cervical LN had a summary sensitivity of 81% and a specificity of 85%, and the area under the curve was 0.88 22 . In subsequent studies of SWE, regarding a relatively large number of patients 12 , metastasis from nasopharyngeal carcinoma 23 and lymphoma in pediatric patients 24 , consistently show more stiffness of malignant LN than benign LN. Although most of these studies implement acoustic radiation force impulse imaging (ARFI) and Supersonic shear imaging (SSI), there is a one study used Toshiba SWE (T-SWE) for evaluating cervical LAP, the same technique that we used in this study 24 .…”

Section: Discussionmentioning

confidence: 95%

“…Qualitative and quantitative estimates of tissue elasticity from SWE have been used the evaluation of many different types of organs, including the breast, liver, prostate, thyroid glands, blood vessels, salivary glands, musculoskeletal structures, and cervical LN 9 . There are many studies that usefulness of US elastography as a new imaging biomarker in detecting malignant LN (including both metastatic LAP and lymphoma) from benign LAP 5,9–12 . However, there is no study assessing SWE for differentiating metastatic LN from lymphoma in the head and neck region, and there are only a few studies of researching lymphoma in cervical region on strain elastography 6,13 .…”

Section: Introductionmentioning

confidence: 99%

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Differentiating cervical metastatic lymphadenopathy and lymphoma by shear wave elastography

Chae

Jung

Ryoo

et al. 2019

Sci Rep

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Shear wave elastography (SWE) is a recent technological advance of ultrasonography (US) to assess tissue stiffness. The purpose of this study is to assess tissue stiffness of malignant cervical lymph nodes (LN) with SWE, to reveal diagnostic performance of SWE in differentiating metastatic LN from lymphoma, and to assess inter-observer agreement of SWE. We assessed 62 malignant LN (24 lymphomas and 38 metastatic LN) and their median speed was 6.34 m/s and median elasticity was 69.7 kPa. Add of SWE with conventional US improved diagnostic accuracy of differentiating metastasis from lymphoma (16.13, 8.07 and 11.3% for three radiologists). Kendall’s Coefficient of Concordance of three readers for analyzing SWE patterns was 0.86. SWE can be a useful tool to discriminate metastatic cervical LN from lymphoma with improvement of diagnostic accuracy when using with conventional US.

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Section: Discussionmentioning

confidence: 95%

Section: Introductionmentioning

confidence: 99%

Differentiating cervical metastatic lymphadenopathy and lymphoma by shear wave elastography

Chae

Jung

Ryoo

et al. 2019

Sci Rep

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“…Different researches have been conducted to examine the quantitative elasticity values in the diagnostic performance of thyroid nodules [12], metastatic and nonmetastatic cervical lymph nodes [13], and acute pancreatitis [14]. In differentiating benign and malignant breast masses, there is an increasing trend to use VTQ measurement [15,16].…”

Section: Discussionmentioning

confidence: 99%

Diagnostic Performance of Superb Microvascular Imaging (SMI) Combined with Shear-Wave Elastography in Evaluating Breast Lesions

et al. 2018

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BackgroundThis study explored the diagnostic value of a combined modality of Superb Microvascular Imaging (SMI) and shear-wave elastography in differentiating malignant and benign breast lesions.Material/MethodsA total of 121 patients with 123 breast lesions enrolled underwent conventional ultrasound exam (US), Color Doppler Flow Imaging (CDFI), SMI examination, and Virtual Touch Tissue Quantification (VTQ) measurement between May 2016 and October 2017. Vessels were detected by both CDFI and SMI in a quantitative manner. The stiffness of all the breast tissues was evaluated by VTQ method. We further assessed the diagnostic performances of CDFI, SMI, VTQ, CDFI+VTQ, and SMI+VTQ.ResultsBoth CDFI and SMI exhibited significant differences between malignant and benign masses (p<0.001) in terms of Adler classification. The mean shear-wave velocity (SWV) of malignant neoplasms was 5.28 m/s, with interquartile range (IQR) 4.01–6.39 m/s (p<0.001). The mean SWV of benign lesions was 2.64 m/s, with IQR 2.30–5.01 m/s (p<0.001). No significant difference was found for the area under the receiver operating characteristic curve (AUC) for CDFI, SMI, and VTQ (χ2=2.29, P=0.3715). The sensitivity was the highest on SMI+VTQ (85.42%) and the lowest on CDFI (58.33%). CDFI+VTQ (85.33%) had a slightly higher specificity than SMI+VTQ (84.00%). The accuracy rate of these 2 modalities remained the same (84.55%).ConclusionsSuperb Microvascular Imaging yields more detailed vascular information in the bloodstream in benign and malignant breast masses compared with conventional ultrasonography. VTQ provides standardized quantified results in assessing tissue stiffness. The combined modality of SMI+VTQ added to conventional ultrasonography presented a better diagnostic performance in differentiating malignant breast neoplasms.

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“…In contrast to static elastography, absolute SWV values expressed in m/sec are obtained by evaluating the peak displacement at each transverse wave. A number of studies have evaluated the diagnostic performance of the measurement of quantitative elasticity values of thyroid nodules ( 17 ), metastatic and non-metastatic cervical lymph nodes ( 18 ) and acute pancreatitis ( 19 ). The elastographic standard deviation was rated as a valuable means of measuring heterogeneity in the aforementioned studies.…”

Section: Discussionmentioning

confidence: 99%

Correlation between histopathological grading and shear‑wave elastography in evaluating invasive carcinoma of no special type

et al. 2018

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The present study aimed to investigate the correlation between histologic grade and shear-wave elastography in evaluating invasive breast carcinoma of no special type (NST). A total of 84 breast lesions in 80 patients (age range, 32–64 years) were retrospectively evaluated. The patients underwent B-mode ultrasound and virtual touch tissue quantification diagnosis. A semi-quantitative method was then applied in order to determine the histologic grade of the invasive carcinoma of NST according to the grading system published by the World Health Organization. Among the 84 breast lesions, 14 (16.7%) were classified as Grade I, while 29 (34.5%) and 41 (48.8%) were determined to be of Grade II and Grade III, respectively. The size of the breast lesions increased with the increase in histological grade (P<0.001). In addition, 29.3% of the Grade-III breast lesions exhibited acoustic enhancement, while the majority of the Grade-I breast lesions (78.6%) exhibited acoustic shadowing (P=0.002). Furthermore, a higher histopathological grade was closely correlated with a higher mean, minimum and maximum shear-wave velocity value (P<0.05). In conclusion, regarding the evaluation of invasive breast carcinoma of NST, the histologic grade was strongly correlated with tissue stiffness; a higher histologic grade was associated with a harder lesion. Therefore, shear-wave elastography may provide important clinical reference values.

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Preliminary Evaluation of Virtual Touch Tissue Imaging Quantification for Differential Diagnosis of Metastatic and Nonmetastatic Cervical Lymph Nodes

Abstract: Virtual Touch tissue imaging quantification is efficient in differential diagnosis of metastatic and nonmetastatic cervical lymph nodes.

Cited by 10 publications

References 25 publications

Differentiating cervical metastatic lymphadenopathy and lymphoma by shear wave elastography

Differentiating cervical metastatic lymphadenopathy and lymphoma by shear wave elastography

Diagnostic Performance of Superb Microvascular Imaging (SMI) Combined with Shear-Wave Elastography in Evaluating Breast Lesions

Correlation between histopathological grading and shear‑wave elastography in evaluating invasive carcinoma of no special type

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