Preliminary Evaluation of the Use of Mussel Adhesive Protein in Experimental Epikeratoplasty

Lessons from Sea Organisms to Produce New Biomedical Adhesives

“…Native barnacle cement was shown to be effective in tests of rabbit bone repair [10]. Adhesive proteins extracted from mussels appeared to be nontoxic and well tolerated by biological systems when used in transplantation experiments in vivo (e.g., corneal transplantation in rabbit; [11]). However, in both cases, the difficulty to collect sufficient quantities of adhesive material prevented further use of this material in concrete medical procedures.…”

Lessons from Sea Organisms to Produce New Biomedical Adhesives

“…Native barnacle cement was shown to be effective in tests of rabbit bone repair [10]. Adhesive proteins extracted from mussels appeared to be nontoxic and well tolerated by biological systems when used in transplantation experiments in vivo (e.g., corneal transplantation in rabbit; [11]). However, in both cases, the difficulty to collect sufficient quantities of adhesive material prevented further use of this material in concrete medical procedures.…”

Understanding Marine Mussel Adhesion

“…Dr. Robin L. Garrell (Organic Chemistry Department, University of California, Los Angeles [UCLA]) has worked on elucidating the chemical mechanisms for adhesion and cohesion in Mefp-1 and other marine biopolymers to develop artificial tissues and bioreactors (Ooka and Garrell 2000 ; http://www.chem.ucla.edu/dept/Organic/garrell.html ). Future dental and medical adhesives may contain mussel adhesive proteins and/or domains from mussel adhesives (Tay and Pashley 2002 ; Ninan et al 2003 ; Fulkerson et al 1990 ; Robin et al 1988 ; Schmidt et al 1994 ).…”

Protein-based underwater adhesives and the prospects for their biotechnological production

“…Over a seven-day period, only microdrops of the cement were produced.” This is sufficient explanation for why native barnacle cement is not used in dentistry to this day. In a similar vein, native mussel foot proteins (mfps) were tested in rabbit cornea transplants (Robin et al 1988) and for soft tissue repair (Papatheofanis and Ray 1982; Ninan et al 2007). Like barnacle cement, native mfps are not used in eye surgery or any other medical procedure, though native mfps isolated from cultured mussels are still commercially available in mg quantities and are priced like life-saving medicine (Cell-Tak, BDBiosciences).…”

Lessons from Sea Organisms to Produce New Biomedical Adhesives

“…Native barnacle cement was shown to be effective in tests of rabbit bone repair [10]. Adhesive proteins extracted from mussels appeared to be nontoxic and well tolerated by biological systems when used in transplantation experiments in vivo (e.g., corneal transplantation in rabbit; [11]). However, in both cases, the difficulty to collect sufficient quantities of adhesive material prevented further use of this material in concrete medical procedures.…”

Understanding Marine Mussel Adhesion

“…Dr. Robin L. Garrell (Organic Chemistry Department, University of California, Los Angeles [UCLA]) has worked on elucidating the chemical mechanisms for adhesion and cohesion in Mefp-1 and other marine biopolymers to develop artificial tissues and bioreactors (Ooka and Garrell 2000 ; http://www.chem.ucla.edu/dept/Organic/garrell.html ). Future dental and medical adhesives may contain mussel adhesive proteins and/or domains from mussel adhesives (Tay and Pashley 2002 ; Ninan et al 2003 ; Fulkerson et al 1990 ; Robin et al 1988 ; Schmidt et al 1994 ).…”

Protein-based underwater adhesives and the prospects for their biotechnological production

“…Over a seven-day period, only microdrops of the cement were produced.” This is sufficient explanation for why native barnacle cement is not used in dentistry to this day. In a similar vein, native mussel foot proteins (mfps) were tested in rabbit cornea transplants (Robin et al 1988) and for soft tissue repair (Papatheofanis and Ray 1982; Ninan et al 2007). Like barnacle cement, native mfps are not used in eye surgery or any other medical procedure, though native mfps isolated from cultured mussels are still commercially available in mg quantities and are priced like life-saving medicine (Cell-Tak, BDBiosciences).…”

Lessons from Sea Organisms to Produce New Biomedical Adhesives

“…Native barnacle cement was shown to be effective in tests of rabbit bone repair [10]. Adhesive proteins extracted from mussels appeared to be nontoxic and well tolerated by biological systems when used in transplantation experiments in vivo (e.g., corneal transplantation in rabbit; [11]). However, in both cases, the difficulty to collect sufficient quantities of adhesive material prevented further use of this material in concrete medical procedures.…”

Understanding Marine Mussel Adhesion

“…Dr. Robin L. Garrell (Organic Chemistry Department, University of California, Los Angeles [UCLA]) has worked on elucidating the chemical mechanisms for adhesion and cohesion in Mefp-1 and other marine biopolymers to develop artificial tissues and bioreactors (Ooka and Garrell 2000 ; http://www.chem.ucla.edu/dept/Organic/garrell.html ). Future dental and medical adhesives may contain mussel adhesive proteins and/or domains from mussel adhesives (Tay and Pashley 2002 ; Ninan et al 2003 ; Fulkerson et al 1990 ; Robin et al 1988 ; Schmidt et al 1994 ).…”

Protein-based underwater adhesives and the prospects for their biotechnological production

“…Over a seven-day period, only microdrops of the cement were produced.” This is sufficient explanation for why native barnacle cement is not used in dentistry to this day. In a similar vein, native mussel foot proteins (mfps) were tested in rabbit cornea transplants (Robin et al 1988) and for soft tissue repair (Papatheofanis and Ray 1982; Ninan et al 2007). Like barnacle cement, native mfps are not used in eye surgery or any other medical procedure, though native mfps isolated from cultured mussels are still commercially available in mg quantities and are priced like life-saving medicine (Cell-Tak, BDBiosciences).…”