Preliminary Evaluation of the Use of Mussel Adhesive Protein in Experimental Epikeratoplasty

Robin, Jeffrey B.; Picciano, Paul; Kusleika, Richard S.; Salazar, Jessica; Benedict, Christine V.

doi:10.1001/archopht.1988.01060140119037

Cited by 20 publications

(6 citation statements)

References 21 publications

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“…Native barnacle cement was shown to be effective in tests of rabbit bone repair [10]. Adhesive proteins extracted from mussels appeared to be nontoxic and well tolerated by biological systems when used in transplantation experiments in vivo (e.g., corneal transplantation in rabbit; [11]). However, in both cases, the difficulty to collect sufficient quantities of adhesive material prevented further use of this material in concrete medical procedures.…”

Section: Introductioncontrasting

confidence: 40%

Lessons from Sea Organisms to Produce New Biomedical Adhesives

Hennebert

Becker

Flammang

2012

Biomimetic Approaches for Biomaterials Development

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Section: Introductioncontrasting

confidence: 40%

Lessons from Sea Organisms to Produce New Biomedical Adhesives

Hennebert

Becker

Flammang

2012

Biomimetic Approaches for Biomaterials Development

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“…Dr. Robin L. Garrell (Organic Chemistry Department, University of California, Los Angeles [UCLA]) has worked on elucidating the chemical mechanisms for adhesion and cohesion in Mefp-1 and other marine biopolymers to develop artificial tissues and bioreactors (Ooka and Garrell 2000 ; http://www.chem.ucla.edu/dept/Organic/garrell.html ). Future dental and medical adhesives may contain mussel adhesive proteins and/or domains from mussel adhesives (Tay and Pashley 2002 ; Ninan et al 2003 ; Fulkerson et al 1990 ; Robin et al 1988 ; Schmidt et al 1994 ).…”

Section: Current and Future Research Areas Related To Mussel Adhesionmentioning

confidence: 99%

Understanding Marine Mussel Adhesion

2007

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In addition to identifying the proteins that have a role in underwater adhesion by marine mussels, research efforts have focused on identifying the genes responsible for the adhesive proteins, environmental factors that may influence protein production, and strategies for producing natural adhesives similar to the native mussel adhesive proteins. The production-scale availability of recombinant mussel adhesive proteins will enable researchers to formulate adhesives that are waterimpervious and ecologically safe and can bind materials ranging from glass, plastics, metals, and wood to materials, such as bone or teeth, biological organisms, and other chemicals or molecules. Unfortunately, as of yet scientists have been unable to duplicate the processes that marine mussels use to create adhesive structures. This study provides a background on adhesive proteins identified in the blue mussel, Mytilus edulis, and introduces our research interests and discusses the future for continued research related to mussel adhesion.

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“…Over a seven-day period, only microdrops of the cement were produced.” This is sufficient explanation for why native barnacle cement is not used in dentistry to this day. In a similar vein, native mussel foot proteins (mfps) were tested in rabbit cornea transplants (Robin et al 1988) and for soft tissue repair (Papatheofanis and Ray 1982; Ninan et al 2007). Like barnacle cement, native mfps are not used in eye surgery or any other medical procedure, though native mfps isolated from cultured mussels are still commercially available in mg quantities and are priced like life-saving medicine (Cell-Tak, BDBiosciences).…”

Section: Production Prospectsmentioning

confidence: 99%

Protein-based underwater adhesives and the prospects for their biotechnological production

Stewart

2010

Appl Microbiol Biotechnol

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Biotechnological approaches to practical production of biological protein-based adhesives have had limited success over the last several decades. Broader efforts to produce recombinant adhesive proteins may have been limited by early disappointments. More recent synthetic polymer approaches have successfully replicated some aspects of natural underwater adhesives. For example, synthetic polymers, inspired by mussels, containing the catecholic functional group of 3,4-L-dihydroxyphenylalanine adhere strongly to wet metal oxide surfaces. Synthetic complex coacervates inspired by the Sandcastle worm are water-borne adhesives that can be delivered underwater without dispersing. Synthetic approaches offer several advantages, including versatile chemistries and scalable production. In the future, more sophisticated mimetic adhesives may combine synthetic copolymers with recombinant or agriculture-derived proteins to better replicate the structural and functional organization of natural adhesives.

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Preliminary Evaluation of the Use of Mussel Adhesive Protein in Experimental Epikeratoplasty

Cited by 20 publications

References 21 publications

Lessons from Sea Organisms to Produce New Biomedical Adhesives

Lessons from Sea Organisms to Produce New Biomedical Adhesives

Understanding Marine Mussel Adhesion

Protein-based underwater adhesives and the prospects for their biotechnological production

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