Preliminary evaluation of serum total cholesterol concentrations in dogs with osteosarcoma

Leeper, Haley; Viall, Austin K.; Ruaux, Craig G.; Bracha, Shay

doi:10.1111/jsap.12702

Cited by 9 publications

(8 citation statements)

References 55 publications

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“…[1–5, 11] Studies report appendicular OS to be largely a disease of middle-aged to older dogs with the median age at diagnosis generally ranging from 6 to 9 years. [2–4, 8, 10, 12–16] Males have been over-represented in some reports but this finding has not been supported in other reports. [2, 3, 7–10, 12–18] Endogenous sex hormones may play a role in sarcomagenesis–some studies have identified significantly increased risk of developing OS in neutered compared to intact dogs.…”

Section: Introductionmentioning

confidence: 91%

“…[2–4, 8, 10, 12–16] Males have been over-represented in some reports but this finding has not been supported in other reports. [2, 3, 7–10, 12–18] Endogenous sex hormones may play a role in sarcomagenesis–some studies have identified significantly increased risk of developing OS in neutered compared to intact dogs. [13, 19–21] Appendicular OS has been commonly reported in large and giant breed dogs, with increased incidence of disease in certain breeds including boxers, Great Danes, Rottweilers, Saint Bernards, Irish setters, Doberman pinschers, greyhounds, German shepherds, Irish wolfhounds and Leonbergers.…”

Section: Introductionmentioning

confidence: 96%

“…[1–5] Osteosarcoma of the appendicular skeleton occurs more commonly than OS of the axial skeleton. [3, 6–10] The demographic characteristics from populations of dogs affected by appendicular OS have been extensively described, with some reports dating back decades. [1–5, 11] Studies report appendicular OS to be largely a disease of middle-aged to older dogs with the median age at diagnosis generally ranging from 6 to 9 years.…”

Section: Introductionmentioning

confidence: 99%

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Demographic characteristics, site and phylogenetic distribution of dogs with appendicular osteosarcoma: 744 dogs (2000-2015)

et al. 2019

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ObjectiveTo report demographic characteristics of a contemporary population of dogs with appendicular osteosarcoma and assess the relationship between demographic characteristics, site distribution, and phylogenetic breed clusters.DesignRetrospective case series.MethodsA search of the Veterinary Medical Database was performed for dogs with appendicular osteosarcoma as a new diagnosis. Entries were reviewed for the sex, neuter status, age at diagnosis, breed, affected limb, and tumor location. The reported breed for purebred dogs was used to categorize each dog into one of five phylogenetic groups based on microsatellite analysis.Results744 client-owned dogs were included in the study. Study dogs were represented by a male-to-female ratio of 0.95:1.0, the majority of which (80.9%) were neutered. Most dogs were diagnosed between 7–10 years of age. The majority (77.8%) of dogs were large or giant-breed dogs. Purebred dogs comprised 80.4% of the population. The most common purebred breed affected by OS was the Rottweiler (17.1%). The most common phylogenetic group represented was Mastiff-Terrier (M-T, 26.3%). OS was more commonly located in the forelimb (64.2%) versus the hindlimb (35.8%), and the humerus was the most common site (20.9%). The distribution of age groups and tumor locations were significantly different between phylogenetic clusters. The distribution of age groups and neuter status were significantly different between size groups.Conclusions and significanceThe demographic data of canine appendicular OS are similar to previous reports. The data on phylogenetic associations can guide future studies aimed at evaluating the genomic mutations that contribute to OS development and its biological behavior.

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Section: Introductionmentioning

confidence: 91%

Section: Introductionmentioning

confidence: 96%

Section: Introductionmentioning

confidence: 99%

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Demographic characteristics, site and phylogenetic distribution of dogs with appendicular osteosarcoma: 744 dogs (2000-2015)

et al. 2019

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“…Osteosarcoma almost always originates in the skeletal system (Figure 2). It can affect either the appendicular or axial skeleton; however, osteosarcoma is most commonly diagnosed in the long bones of the extremities in both dogs (estimated at 56–86% of cases) [3,9,61] and humans (75.6–96.8% of cases) [1,12,62]. It is worth noting, however, that in species other than dogs and humans, osteosarcoma occurs most commonly in the axial skeleton.…”

Section: Introductionmentioning

confidence: 99%

Risk Factors for Development of Canine and Human Osteosarcoma: A Comparative Review

Makielski

Mills

Sarver

et al. 2019

Veterinary Sciences

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Osteosarcoma is the most common primary tumor of bone. Osteosarcomas are rare in humans, but occur more commonly in dogs. A comparative approach to studying osteosarcoma has highlighted many clinical and biologic aspects of the disease that are similar between dogs and humans; however, important species-specific differences are becoming increasingly recognized. In this review, we describe risk factors for the development of osteosarcoma in dogs and humans, including height and body size, genetics, and conditions that increase turnover of bone-forming cells, underscoring the concept that stochastic mutational events associated with cellular replication are likely to be the major molecular drivers of this disease. We also discuss adaptive, cancer-protective traits that have evolved in large, long-lived mammals, and how increasing size and longevity in the absence of natural selection can account for the elevated bone cancer risk in modern domestic dogs.

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“…In this case, the white-eared opossum was clearly an adult, even though it was not possible to define its age precisely, as a consequence of being a wild animal. Osteosarcoma habitually originates from the skeletal system, affecting both appendicular and axial skeletons, though the most common is found on long bone extremities of dogs and humans (Longhi et al 2005, Anfinsen et al 2011, Leeper et al 2017. In the present case, the neoplasm was located at the appendicular skeleton, in the bone structure area forming the left humerus-radio-ulnar joint, likewise suggesting an initial injury at the bone extremity.…”

Section: Resultsmentioning

confidence: 48%

Fibroblastic osteosarcoma in a white-eared opossum (Didelphis albiventris)

et al. 2020

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Osteosarcoma is characterized by the production of osteoid or woven bone, using neoplastic osteoblasts. It is the most common primary bone neoplasm in canines and humans. This neoplasm was previously reported in all vertebrate classes, including a wide variety of mammals. However, there is no case report describing this neoplasm in Didelphis albiventris. Therefore, the objective of this manuscript is to describe the clinical-pathological aspects of fibroblastic osteosarcoma in D. albiventris. A wild adult male white-eared opossum (D. albiventris) arrived at the zoological park of the “Universidade de Caxias do Sul” with a swollen left thoracic limb. After a general clinical examination, the animal was transferred to the Veterinary Clinic of “Universidade de Caxias do Sul” for radiographic examination of the left thoracic limb and thorax. Additionally, some material was collected through fine needle aspiration (FNA) for cytologic evaluation. The radiographic findings and cytologic evaluation indicated osteosarcoma. The animal was euthanized due to severe clinical conditions and guarded prognosis. During necropsy, macroscopic analysis of the viscera was performed, fragments of various organs were collected and fixed in 10% neutral buffered formalin. All fragments were processed following routine histological techniques. The histopathological evaluation confirmed osteosarcoma, which was classified as a fibroblastic subtype. Case reports are crucial for the knowledge of incidence, prevalence, and behavior of the current mentioned disease, as well as other diseases, in species with such limited information. In order to obtain a decisive diagnosis, a few different examination methods were associated. Although the observations presented are based on a single case, this neoplasm had a similar clinical presentation to that described in other species.

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Preliminary evaluation of serum total cholesterol concentrations in dogs with osteosarcoma

Abstract: These results suggest that elevated total cholesterol is associated with canine osteosarcoma and may have prognostic significance.

Cited by 9 publications

References 55 publications

Demographic characteristics, site and phylogenetic distribution of dogs with appendicular osteosarcoma: 744 dogs (2000-2015)

Demographic characteristics, site and phylogenetic distribution of dogs with appendicular osteosarcoma: 744 dogs (2000-2015)

Risk Factors for Development of Canine and Human Osteosarcoma: A Comparative Review

Fibroblastic osteosarcoma in a white-eared opossum (Didelphis albiventris)

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