Preliminary evaluation of particle systems visualization on the skin surface by scanning electron microscopy and transparency profilometry

Perugini, Paola; Vettor, Manuela Teresa; Bleve, Mariella; Bruni, Giovanna; Mondelli, A.; Secchi, G. F.; Pavanetto, F

doi:10.1111/j.1600-0846.2011.00529.x

Cited by 5 publications

(4 citation statements)

References 12 publications

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“…The use of replicas is time-consuming and, therefore, not feasible in an outpatient setting. In addition, air bubbles, gravity, and patient movement may have an effect on the quality of the replica [ 37 ]. Another measurement method is the use of skin biopsy specimens but this technique is invasive [ 38 ].…”

Section: Introductionmentioning

confidence: 99%

Ultrasound and 3D Skin Imaging: Methods to Evaluate Efficacy of Striae Distensae Treatment

Bleve

Capra

Pavanetto

et al. 2012

Dermatology Research and Practice

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Background. Over time, the striae rubra develop into striae alba that appear white, flat, and depressed. It is very important to determine the optimum striae management. In order to evaluate the effectiveness of these therapies, objective measurement tools are necessary. Objective. The aim of this study is to evaluate if ultrasonography and PRIMOS can be used to obtain an objective assessment of stretch marks type and stage; furthermore, we aim to apply these techniques to evaluate the efficacy of a topical treatment. Methods. 20 volunteers were enrolled with a two-month study. A marketed cosmetic product was used as the active over one body area. The controlateral area with stretch marks was treated with a “placebo” formulation without active, as a control. The instrumental evaluation was carried out at the beginning of the trial (baseline values or t 0), after 1 month (t 1), and at the end of the study (t 2). Results. PRIMOS was able to measure and document striae distensae maturation; furthermore, ultrasound imaging permitted to visualize and diagnose the striae. Statistical analysis of skin roughness demonstrated a statistically significant reduction of Rp value only in a treated group. In fact, the Rp value represented a maximum peak height in the area selected. These results demonstrated that after two months of treatment only the striae rubra can be treated successfully. Conclusions. This work demonstrated that the 22MHz ultrasound can diagnose stretch marks; PRIMOS device can detect and measure striae distensae type and maturation. Furthermore, the high-frequency ultrasound and the 3D image device, described in this work, can be successfully employed in order to evaluate the efficacy of a topical treatment.

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Section: Introductionmentioning

confidence: 99%

Ultrasound and 3D Skin Imaging: Methods to Evaluate Efficacy of Striae Distensae Treatment

Bleve

Capra

Pavanetto

et al. 2012

Dermatology Research and Practice

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“…Thanks to image analysis, the study of skin roughness can be resorted to in a quantitative manner, using methods that are scientifically validated and often used in clinical studies 42 …”

Section: Resultsmentioning

confidence: 99%

“…Thanks to image analysis, the study of skin roughness can be resorted to in a quantitative manner, using methods that are scientifically validated and often used in clinical studies. 42 As explained above, thanks to Ra and Rz values measured at time 0 and after treatment, we can investigate the functionality of the cosmetic product with an anti-aging claim.…”

Section: Anti-aging Effectmentioning

confidence: 99%

In vitro and in vivo efficacy of a cosmetic product formulated with new lipid particles for the treatment of aged skin

Catalano,

Mitri,

Perugini

et al. 2023

J of Cosmetic Dermatology

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BackgroundThe cumulative oxidative damage causes an acceleration in the skin aging.ObjectivesTo evaluate the ability of a new patented matrix of lipid particles (SIREN CAPSULE TECHNOLOGY™) to have superior anti‐aging properties due to its high sensitivity to reactive oxygen species (ROS), testing its efficacy versus free or encapsulated vitamins.MethodsAn in vitro study was conducted to evaluate the protective effects of lipid particles using menadione as an enhancer of oxidative stress. Subsequently, in vivo studies evaluated skin hydration, skin barrier function, and smoothness and wrinkle depth. For this purpose, gels containing free or encapsulated vitamins were used as controls.ResultsIn vitro, the SIREN CAPSULE TECHNOLOGY™ gel shows inhibitory activity against ROS production through menadione induction. In fact, at both tested concentrations, ROS production is lower than in the control samples (placebo, free vitamins, encapsulated vitamins).In vivo, the net effect of SIREN CAPSULE TECHNOLOGY™ gel versus the others permitted to conclude that lipid particles exert a higher skin moisturizing effect (20.17%) and a stronger effect in reducing transepidermal water loss (−16.29%) after 4 weeks of treatment. As for surface analysis, a gel based on SIREN CAPSULE TECHNOLOGY™ improves the skin texture in a similar way than gel containing encapsulated vitamins (Ra and Rz variations in 4 weeks).ConclusionsSIREN CAPSULE TECHNOLOGY™ represents an advance and a successful strategy to develop cosmetic products for the treatment of skin conditions associated with an accumulation of ROS. SIREN CAPSULE TECHNOLOGY™ represents a result‐oriented breakthrough in the effective delivery of active ingredients to the skin.

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“…Furthermore a constant pressure of about the gel applied on the skin must be applied in order to obtain replicas with reproducible thickness [Bogner et al 2007]. Perugini et al demonstrated how the association of skin replica and Scanning Electron Microscopy (SEM) can be used for in vivo visualization of solid lipid nanoparticles on the skin surface [Perugini et al, 2011]. The results highlighted that particle with different matrix composition had a different behaviour.…”

Section: Replicamentioning

confidence: 99%

Solid Lipid Nanoparticles: Technological Developments and in Vivo Techniques to Evaluate Their Interaction with the Skin

Bleve¹,

Pavanetto²,

Perugini³

2011

Progress in Molecular and Environmental Bioengineering - From Analysis and Modeling to Technology Applications

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Preliminary evaluation of particle systems visualization on the skin surface by scanning electron microscopy and transparency profilometry

Cited by 5 publications

References 12 publications

Ultrasound and 3D Skin Imaging: Methods to Evaluate Efficacy of Striae Distensae Treatment

Ultrasound and 3D Skin Imaging: Methods to Evaluate Efficacy of Striae Distensae Treatment

In vitro and in vivo efficacy of a cosmetic product formulated with new lipid particles for the treatment of aged skin

Solid Lipid Nanoparticles: Technological Developments and in Vivo Techniques to Evaluate Their Interaction with the Skin

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